Probenecid
- Generic Name
- Probenecid
- Brand Names
- -
- Drug Type
- Small Molecule
- Chemical Formula
- C13H19NO4S
- CAS Number
- 57-66-9
- Unique Ingredient Identifier
- PO572Z7917
- Background
The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
- Indication
For the reduction of serum uric acid concentrations in chronic gouty arthritis and tophaceous gout in patients with frequent disabling gout attacks. Has also been effectively used to promote uric acid excretion in hyperuricemia secondary to the administration of thiazide and related diuretics.
- Associated Conditions
- Bacterial Infections, Chronic Gouty Arthritis, Elevated Serum Uric Acid, Gout Chronic, Hyperuricemia, Infection
- Associated Therapies
- -
The Safety and Effectiveness of Cidofovir in the Treatment of Cytomegalovirus (CMV) of the Eyes in Patients With AIDS
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2005-06-24
- Lead Sponsor
- Gilead Sciences
- Target Recruit Count
- 48
- Registration Number
- NCT00002437
- Locations
- 🇬🇧
Charing Cross and Westminster Med School, London SW 10, United Kingdom
🇺🇸Mount Zion Med Ctr, San Francisco, California, United States
🇺🇸Univ of North Carolina Hosps, Chapel Hill, North Carolina, United States
HPMPC (Cidofovir) Peripheral CMV Retinitis Trial Protocol
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2012-11-01
- Target Recruit Count
- 100
- Registration Number
- NCT00000799
- Locations
- 🇺🇸
Johns Hopkins Hosp / SOCA, Baltimore, Maryland, United States
🇺🇸UCSD - Shiley Eye Ctr / SOCA, La Jolla, California, United States
🇺🇸UCLA - Jules Stein Eye Institute / SOCA, Los Angeles, California, United States
Safety and Tolerance of Zidovudine With Probenecid and the Effect of Probenecid on Zidovudine Pharmacokinetics Over Four Weeks
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2021-11-03
- Target Recruit Count
- 16
- Registration Number
- NCT00000670
- Locations
- 🇺🇸
UCD Med Ctr, Sacramento, California, United States
🇺🇸Johns Hopkins Hosp, Baltimore, Maryland, United States
Comparison of Two Drugs, Cidofovir and Ganciclovir, in Treating Patients With AIDS Who Have CMV Retinitis
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2011-02-23
- Target Recruit Count
- 300
- Registration Number
- NCT00000894
- Locations
- 🇺🇸
Cornell Univ Med Ctr, New York, New York, United States
🇺🇸Julio Arroyo, West Columbia, South Carolina, United States
🇺🇸New York Hosp / Cornell Med Ctr, New York, New York, United States
Influence of Probenecid and Quinine on the Pharmacokinetics of Azidothymidine
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2021-11-03
- Target Recruit Count
- 12
- Registration Number
- NCT00000706
- Locations
- 🇺🇸
Johns Hopkins Hosp, Baltimore, Maryland, United States
A Study of Cidofovir in HIV-Infected Children With Cytomegalovirus (CMV) Disease
- Conditions
A Study to Evaluate the Use of Cidofovir (an Experimental Drug) for the Treatment of Progressive Multifocal Leukoencephalopathy (PML) in AIDS Patients
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2021-10-29
- Target Recruit Count
- 24
- Registration Number
- NCT00000945
- Locations
- 🇺🇸
Rush Presbyterian - Saint Luke's Med Ctr, Chicago, Illinois, United States
🇺🇸San Francisco AIDS Clinic / San Francisco Gen Hosp, San Francisco, California, United States
🇺🇸Univ of Alabama at Birmingham, Birmingham, Alabama, United States
Drug Development Updates
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