Probenecid

Generic Name: Probenecid

Drug Type: Small Molecule

Chemical Formula: C_₁₃H_₁₉NO_₄S

CAS Number: 57-66-9

Unique Ingredient Identifier: PO572Z7917

Background: The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.

Indication: For the reduction of serum uric acid concentrations in chronic gouty arthritis and tophaceous gout in patients with frequent disabling gout attacks. Has also been effectively used to promote uric acid excretion in hyperuricemia secondary to the administration of thiazide and related diuretics.

Associated Conditions: Bacterial Infections, Chronic Gouty Arthritis, Elevated Serum Uric Acid, Gout Chronic, Hyperuricemia, Infection

Clinical Trials

Evaluation of Renal Drug Transport in Healthy Volunteers

Not Applicable

Completed

Conditions: Kidney Disease

Interventions: Drug: probenecid

First Posted Date: 2008-06-04

Last Posted Date: 2021-05-11

Lead Sponsor: University of Maryland, Baltimore

Target Recruit Count: 10

Registration Number: NCT00690014

Locations: 🇺🇸
University of Maryland GCRC, Baltimore, Maryland, United States

Pharmacologic Study of Oseltamivir in Healthy Volunteers

Phase 1

Completed

Conditions: Avian Influenza A Virus

First Posted Date: 2007-02-23

Last Posted Date: 2009-07-28

Lead Sponsor: Mahidol University

Target Recruit Count: 21

Registration Number: NCT00439530

Locations: 🇹🇭
Bangkok Hospital for Tropical Diseases Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

Evaluation of Alternative Oseltamivir (Tamiflu) Dosing Strategies.

Phase 4

Completed

Conditions: Influenza

Interventions: Drug: Oseltamivir
Drug: Probenecid

First Posted Date: 2006-03-17

Last Posted Date: 2009-09-23

Lead Sponsor: US Department of Veterans Affairs

Target Recruit Count: 48

Registration Number: NCT00304434

Locations: 🇺🇸
VA Palo Alto Health Care System, Palo Alto, California, United States

Primary Prevention of Hypertension in Obese Adolescents

Phase 2

Completed

Conditions: Obesity
Pre-Hypertension
Hyperuricemia

Interventions: Drug: Placebo
Drug: Allopurinol
Drug: Probenecid

First Posted Date: 2006-02-07

Last Posted Date: 2017-09-14

Lead Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Target Recruit Count: 60

Registration Number: NCT00288158

Locations: 🇺🇸
Texas Children's Hospital, Houston, Texas, United States

10-Propargyl-10-Deazaaminopterin Plus Probenecid in Treating Patients With Advanced Solid Tumors

Phase 1

Completed

Conditions: Unspecified Adult Solid Tumor, Protocol Specific

First Posted Date: 2003-01-27

Last Posted Date: 2013-06-26

Lead Sponsor: Memorial Sloan Kettering Cancer Center

Registration Number: NCT00024245

Locations: 🇺🇸
Memorial Sloan-Kettering Cancer Center, New York, New York, United States

Influence of Probenecid and Quinine on the Pharmacokinetics of Azidothymidine

Not Applicable

Completed

Conditions: HIV Infections

First Posted Date: 2001-08-31

Last Posted Date: 2021-11-03

Lead Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Target Recruit Count: 12

Registration Number: NCT00000706

Locations: 🇺🇸
Johns Hopkins Hosp, Baltimore, Maryland, United States

HPMPC (Cidofovir) Peripheral CMV Retinitis Trial Protocol

Not Applicable

Completed

Conditions: Cytomegalovirus Retinitis
HIV Infections

First Posted Date: 2001-08-31

Last Posted Date: 2012-11-01

Lead Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Target Recruit Count: 100

Registration Number: NCT00000799

Locations: 🇺🇸
Johns Hopkins Hosp / SOCA, Baltimore, Maryland, United States
🇺🇸
UCSD - Shiley Eye Ctr / SOCA, La Jolla, California, United States
🇺🇸
UCLA - Jules Stein Eye Institute / SOCA, Los Angeles, California, United States

and more 4 locations

Safety and Tolerance of Zidovudine With Probenecid and the Effect of Probenecid on Zidovudine Pharmacokinetics Over Four Weeks

Not Applicable

Completed

Conditions: HIV Infections

First Posted Date: 2001-08-31

Last Posted Date: 2021-11-03

Lead Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Target Recruit Count: 16

Registration Number: NCT00000670

Locations: 🇺🇸
UCD Med Ctr, Sacramento, California, United States
🇺🇸
Johns Hopkins Hosp, Baltimore, Maryland, United States

Comparison of Two Drugs, Cidofovir and Ganciclovir, in Treating Patients With AIDS Who Have CMV Retinitis

Phase 4

Completed

Conditions: Cytomegalovirus Retinitis
HIV Infections

First Posted Date: 2001-08-31

Last Posted Date: 2011-02-23

Lead Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Target Recruit Count: 300

Registration Number: NCT00000894

Locations: 🇺🇸
Cornell Univ Med Ctr, New York, New York, United States
🇺🇸
Julio Arroyo, West Columbia, South Carolina, United States
🇺🇸
New York Hosp / Cornell Med Ctr, New York, New York, United States

and more 9 locations

An Open-Label Study of the Safety and Efficacy of Cidofovir for the Treatment of Relapsing Cytomegalovirus Retinitis in Patients With AIDS

Not Applicable

Completed

Conditions: Cytomegalovirus Retinitis
HIV Infections

First Posted Date: 2001-08-31

Last Posted Date: 2005-06-24

Lead Sponsor: Gilead Sciences

Target Recruit Count: 100

Registration Number: NCT00002142

Locations: 🇺🇸
Besselaar Associates, Princeton, New Jersey, United States

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