Overview
Ammonia is a naturally-occurring compound with a chemical formula NH3 and structure of trigonal pyramidal geometry. It is a colorless gas with a pungent smell, and become NH4, or ammonium ion, when in water. Although ammonia is used as a food additive in the anhydrous form and serves as a starting material in pharmaceutical and commercial products, it is caustic and hazardous when concentrated. Ammonia gas has been used in the clinical setting as a respiratory stimulant to prevent fainting. The radiolabelled form of ammonia, ammonia N 13, is intravenously administered as a radioactive diagnostic agent for Positron Emission Tomography (PET) imaging of the myocardium to evaluate myocardial perfusion. Ammonia is a natural byproduct of biological and chemical reactions, including decomposition of organic matter, including plants, animals, and animal wastes. It is present in normally present in all tissues constituting a metabolic pool, where it is mostly taken up by glutamic acid and take part in transamination and other reactions, including the synthesis of protein by the Krebs-Hanseleit cycle in the liver . It is proposed that human adults produce about 1000 mmol of ammonia daily, most of which undergoes excretion in the urine.
Background
Ammonia is a naturally-occurring compound with a chemical formula NH3 and structure of trigonal pyramidal geometry. It is a colorless gas with a pungent smell, and become NH4, or ammonium ion, when in water. Although ammonia is used as a food additive in the anhydrous form and serves as a starting material in pharmaceutical and commercial products, it is caustic and hazardous when concentrated. Ammonia gas has been used in the clinical setting as a respiratory stimulant to prevent fainting. The radiolabelled form of ammonia, ammonia N 13, is intravenously administered as a radioactive diagnostic agent for Positron Emission Tomography (PET) imaging of the myocardium to evaluate myocardial perfusion. Ammonia is a natural byproduct of biological and chemical reactions, including decomposition of organic matter, including plants, animals, and animal wastes. It is present in normally present in all tissues constituting a metabolic pool, where it is mostly taken up by glutamic acid and take part in transamination and other reactions, including the synthesis of protein by the Krebs-Hanseleit cycle in the liver . It is proposed that human adults produce about 1000 mmol of ammonia daily, most of which undergoes excretion in the urine.
Indication
No indication information available.
Associated Conditions
- Skin Irritation
- Syncope or fainting sensation
Clinical Trials
Title | Posted | Study ID | Phase | Status | Sponsor |
|---|---|---|---|---|---|
2023/05/22 | Phase 1 | Completed | Jan Malecek | ||
2020/04/13 | N/A | Recruiting | |||
2017/05/31 | N/A | Completed | |||
2011/06/09 | Not Applicable | Completed |
FDA Drug Approvals
Approved Product | Manufacturer | NDC Code | Route | Strength | Effective Date |
|---|---|---|---|---|---|
| Jiangxi Hemei Pharmaceutical Co., Ltd | 84010-128 | RESPIRATORY (INHALATION) | 15 g in 100 g | 5/27/2025 | |
| KINKANDO CO., LTD . | 51027-0007 | TOPICAL | 1.1 g in 50 mL | 6/10/2025 | |
| Washburn Ventures LLC | 85764-001 | RESPIRATORY (INHALATION) | 15 g in 100 g | 6/9/2025 | |
| Sina Health Inc | 70385-2003 | RESPIRATORY (INHALATION) | 0.045 g in 0.3 mL | 2/4/2019 | |
| Shenzhen Nanjun Technology Co., Ltd | 85590-001 | RESPIRATORY (INHALATION) | 15 g in 100 g | 4/29/2025 | |
| Shenzhen Chihai Trading Co., Ltd. | 85670-001 | TOPICAL | 15 g in 100 g | 5/7/2025 | |
| A-S Medication Solutions | 50090-0342 | RESPIRATORY (INHALATION) | 0.045 g in 0.3 mL | 10/12/2020 | |
| Platinum Trident Enterprise | 85570-1111 | NASAL | 15 g in 100 g | 5/22/2025 |
EMA Drug Approvals
Approved Product | Authorization Holder | Status | Issued Date |
|---|---|---|---|
| No EMA approvals found for this drug. | |||
HSA Drug Approvals
Approved Product | Manufacturer | Approval Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No HSA approvals found for this drug. | |||||
NMPA Drug Approvals
Approved Product | Company | Approval Number | Drug Type | Dosage Form | Approval Date |
|---|---|---|---|---|---|
| No NMPA approvals found for this drug. | |||||
PPB Drug Approvals
Approved Product | Registration No. | Company | Licence No. | Strength | Registration Date |
|---|---|---|---|---|---|
| No PPB approvals found for this drug. | |||||
TGA Drug Approvals
Approved Product | ARTG ID | Sponsor | Registration Type | Status | Registration Date |
|---|---|---|---|---|---|
| No TGA approvals found for this drug. | |||||