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Ammonia

Generic Name
Ammonia
Brand Names
Kenalog
Drug Type
Small Molecule
CAS Number
7664-41-7

Overview

Ammonia is a naturally-occurring compound with a chemical formula NH3 and structure of trigonal pyramidal geometry. It is a colorless gas with a pungent smell, and become NH4, or ammonium ion, when in water. Although ammonia is used as a food additive in the anhydrous form and serves as a starting material in pharmaceutical and commercial products, it is caustic and hazardous when concentrated. Ammonia gas has been used in the clinical setting as a respiratory stimulant to prevent fainting. The radiolabelled form of ammonia, ammonia N 13, is intravenously administered as a radioactive diagnostic agent for Positron Emission Tomography (PET) imaging of the myocardium to evaluate myocardial perfusion. Ammonia is a natural byproduct of biological and chemical reactions, including decomposition of organic matter, including plants, animals, and animal wastes. It is present in normally present in all tissues constituting a metabolic pool, where it is mostly taken up by glutamic acid and take part in transamination and other reactions, including the synthesis of protein by the Krebs-Hanseleit cycle in the liver . It is proposed that human adults produce about 1000 mmol of ammonia daily, most of which undergoes excretion in the urine.

Background

Ammonia is a naturally-occurring compound with a chemical formula NH3 and structure of trigonal pyramidal geometry. It is a colorless gas with a pungent smell, and become NH4, or ammonium ion, when in water. Although ammonia is used as a food additive in the anhydrous form and serves as a starting material in pharmaceutical and commercial products, it is caustic and hazardous when concentrated. Ammonia gas has been used in the clinical setting as a respiratory stimulant to prevent fainting. The radiolabelled form of ammonia, ammonia N 13, is intravenously administered as a radioactive diagnostic agent for Positron Emission Tomography (PET) imaging of the myocardium to evaluate myocardial perfusion. Ammonia is a natural byproduct of biological and chemical reactions, including decomposition of organic matter, including plants, animals, and animal wastes. It is present in normally present in all tissues constituting a metabolic pool, where it is mostly taken up by glutamic acid and take part in transamination and other reactions, including the synthesis of protein by the Krebs-Hanseleit cycle in the liver . It is proposed that human adults produce about 1000 mmol of ammonia daily, most of which undergoes excretion in the urine.

Indication

No indication information available.

Associated Conditions

  • Skin Irritation
  • Syncope or fainting sensation

FDA Approved Products

Ammonia Inhalants
Manufacturer:A-S Medication Solutions
Route:RESPIRATORY (INHALATION)
Strength:0.045 g in 0.3 mL
Approved: 2020/10/12
NDC:50090-0342
Ammonia Inhalants
Manufacturer:Sina Health Inc
Route:RESPIRATORY (INHALATION)
Strength:0.045 g in 0.3 mL
Approved: 2019/02/04
NDC:70385-2003
ANTYZE Smelling Salts
Manufacturer:Shenzhen Nanjun Technology Co., Ltd
Route:RESPIRATORY (INHALATION)
Strength:15 g in 100 g
Approved: 2025/04/29
NDC:85590-001
Smelling Salt
Manufacturer:Shenzhen Chihai Trading Co., Ltd.
Route:TOPICAL
Strength:15 g in 100 g
Approved: 2025/05/07
NDC:85670-001

Singapore Approved Products

No Singapore products found for this drug

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