Misoprostol
- Generic Name
- Misoprostol
- Brand Names
- Arthrotec, Cytotec, Mifegymiso
- Drug Type
- Small Molecule
- Chemical Formula
- C22H38O5
- CAS Number
- 59122-46-2
- Unique Ingredient Identifier
- 0E43V0BB57
- Background
Misoprostol is a prostaglandin analog used to reduce the risk of NSAID related ulcers, manage miscarriages, prevent post partum hemorrhage, and also for first trimester abortions. The stimulation of prostaglandin receptors in the stomach reduces gastric acid secretion, while stimulating these receptors in the uterus and cervix can increase the strength and frequency of contractions and decrease cervical tone.
Misoprostol was granted FDA approval on 27 December 1988.
- Indication
Misoprostol is indicated as a tablet to reduce the risk of NSAID induced gastric ulcers but not duodenal ulcers in high risk patients. Misoprostol is also formulated in combination with diclofenac to treat symptoms of osteoarthritis or rheumatoid arthritis in patients with a high risk of developing gastric ulcers. Misoprostol is used off label for the management of miscarriages, prevention of post partum hemorrhage, and is also used alone or in combination with mifepristone in other countries for first trimester abortions.
- Associated Conditions
- Gastric Ulcer, Incomplete Abortion, Missed Abortion, Postpartum Haemorrhage (PPH)
- Associated Therapies
- Induction of cervix ripening therapy, Medically induced abortion
A Prospective Study of Misoprostol Administration in Asymptomatic Patients With Pregnancies of Unknown Location
- Conditions
- Interventions
- First Posted Date
- 2015-10-21
- Last Posted Date
- 2015-10-21
- Lead Sponsor
- Sheba Medical Center
- Target Recruit Count
- 100
- Registration Number
- NCT02581761
Termination Of Anembryonic Pregnancy
- Conditions
- Interventions
- First Posted Date
- 2015-10-09
- Last Posted Date
- 2024-07-31
- Lead Sponsor
- Assiut University
- Registration Number
- NCT02573051
- Locations
- 🇪🇬
Assiut university, Assiut, Egypt
Uterotonics Using to Reduce Bleeding at Cesarean Section
- First Posted Date
- 2015-09-29
- Last Posted Date
- 2020-08-12
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 120
- Registration Number
- NCT02562300
Outpatient Foley Catheter Compared to Usual Inpatient Care for Labor Induction
- First Posted Date
- 2015-09-10
- Last Posted Date
- 2019-06-20
- Lead Sponsor
- Mayo Clinic
- Target Recruit Count
- 39
- Registration Number
- NCT02546193
- Locations
- 🇺🇸
Mayo Clinic in Rochester, Rochester, Minnesota, United States
Cervical Ripening in Postmenopausal Women
- First Posted Date
- 2015-08-28
- Last Posted Date
- 2018-07-12
- Lead Sponsor
- St. Louis University
- Target Recruit Count
- 11
- Registration Number
- NCT02534883
- Locations
- 🇺🇸
St. Mary's Health Center, Saint Louis, Missouri, United States
Comparison of Single and Repeated Dose of Vaginal Misoprostol for the Treatment of Early Pregnancy Failure
- First Posted Date
- 2015-08-05
- Last Posted Date
- 2016-11-01
- Lead Sponsor
- Wolfson Medical Center
- Target Recruit Count
- 180
- Registration Number
- NCT02515604
- Locations
- 🇮🇱
Wolfson Medical Center, Holon, Israel
Could Pre-operative Rectal Misoprostol Reduce Intra-operative Blood Loss During Ceserean Section?
- First Posted Date
- 2015-07-28
- Last Posted Date
- 2016-11-10
- Lead Sponsor
- Ain Shams University
- Target Recruit Count
- 280
- Registration Number
- NCT02509351
- Locations
- 🇪🇬
Faculty of Medicine, Ain Shams University, Cairo, Al Qahirah, Egypt
Medical Management of Late Intrauterine Death.
- Conditions
- Interventions
- First Posted Date
- 2015-07-02
- Last Posted Date
- 2015-07-24
- Lead Sponsor
- National Institute of Perinatology
- Target Recruit Count
- 60
- Registration Number
- NCT02488642
Vaginal Estradiol Pretreatment in Labour Induction With Misoprostol
- Conditions
- Interventions
- First Posted Date
- 2015-06-30
- Last Posted Date
- 2016-02-17
- Lead Sponsor
- Ain Shams University
- Target Recruit Count
- 200
- Registration Number
- NCT02485821
- Locations
- 🇪🇬
Ain Shams University, Cairo, Egypt
Comparative Study on the Effects of Sublingual Misoprostol in Addition to Standard AMTSL in Low Risk Parturients in LASUTH, Ikeja.
- First Posted Date
- 2015-04-22
- Last Posted Date
- 2015-04-30
- Lead Sponsor
- Lagos State University
- Target Recruit Count
- 660
- Registration Number
- NCT02424201
Drug Development Updates
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