Misoprostol
- Generic Name
- Misoprostol
- Brand Names
- Arthrotec, Cytotec, Mifegymiso
- Drug Type
- Small Molecule
- Chemical Formula
- C22H38O5
- CAS Number
- 59122-46-2
- Unique Ingredient Identifier
- 0E43V0BB57
- Background
Misoprostol is a prostaglandin analog used to reduce the risk of NSAID related ulcers, manage miscarriages, prevent post partum hemorrhage, and also for first trimester abortions. The stimulation of prostaglandin receptors in the stomach reduces gastric acid secretion, while stimulating these receptors in the uterus and cervix can increase the strength and frequency of contractions and decrease cervical tone.
Misoprostol was granted FDA approval on 27 December 1988.
- Indication
Misoprostol is indicated as a tablet to reduce the risk of NSAID induced gastric ulcers but not duodenal ulcers in high risk patients. Misoprostol is also formulated in combination with diclofenac to treat symptoms of osteoarthritis or rheumatoid arthritis in patients with a high risk of developing gastric ulcers. Misoprostol is used off label for the management of miscarriages, prevention of post partum hemorrhage, and is also used alone or in combination with mifepristone in other countries for first trimester abortions.
- Associated Conditions
- Gastric Ulcer, Incomplete Abortion, Missed Abortion, Postpartum Haemorrhage (PPH)
- Associated Therapies
- Induction of cervix ripening therapy, Medically induced abortion
Misoprostol Versus Oxytocin for Prevention of Post Partum Hemorrhage
- First Posted Date
- 2013-05-29
- Last Posted Date
- 2015-03-26
- Lead Sponsor
- Hormozgan University of Medical Sciences
- Target Recruit Count
- 400
- Registration Number
- NCT01863706
- Locations
- 🇮🇷
Hormozgan University of Medical Sciences, Bandar Abbas, Hormozgan, Iran, Islamic Republic of
Pre-Operative Effects of Mifepristone on Dilation and Evacuation Services
- Conditions
- Interventions
- First Posted Date
- 2013-05-27
- Last Posted Date
- 2024-02-14
- Lead Sponsor
- Stanford University
- Target Recruit Count
- 80
- Registration Number
- NCT01862991
- Locations
- 🇺🇸
Stanford University Medical Center, Stanford, California, United States
🇺🇸Santa Clara Valley Medical Center, San Jose, California, United States
Acceptability of an Out-patient Regimen of Medical Abortion With Mifepristone and 800 Mcg Misoprostol Administered at 78-84 Days Gestation
- First Posted Date
- 2013-05-20
- Last Posted Date
- 2013-10-11
- Lead Sponsor
- Gynuity Health Projects
- Target Recruit Count
- 50
- Registration Number
- NCT01856985
- Locations
- 🇻🇳
Hung Vuong Hospital, Ho Chi Minh City, Vietnam
Intraumbilical Misoprostol in Retained Placenta
- First Posted Date
- 2013-04-26
- Last Posted Date
- 2013-11-05
- Lead Sponsor
- Hawler Medical University
- Target Recruit Count
- 46
- Registration Number
- NCT01840813
- Locations
- 🇮🇶
Maternity Teaching Hospital, Erbil city, Kurdistan region, Iraq
Same-day Dilapan-S With Adjunctive Misoprostol
- Conditions
- Interventions
- First Posted Date
- 2013-03-26
- Last Posted Date
- 2017-02-28
- Lead Sponsor
- University of Pittsburgh
- Target Recruit Count
- 29
- Registration Number
- NCT01818414
- Locations
- 🇺🇸
Planned Parenthood of Western Pennsylvania, Pittsburgh, Pennsylvania, United States
🇺🇸Univeristy of Pittsburgh, Magee-Womens Hospital of UPMC, Pittsburgh, Pennsylvania, United States
Induction With Foley OR Misoprostol (INFORM) Study
- Conditions
- Interventions
- First Posted Date
- 2013-02-28
- Last Posted Date
- 2015-12-14
- Lead Sponsor
- University of Liverpool
- Target Recruit Count
- 602
- Registration Number
- NCT01801410
- Locations
- 🇮🇳
Government Medical College (GMC), Nagpur, India
🇮🇳Daga Memorial Women's Hospital, Nagpur, Maharashtra, India
Medical Abortion With Mifepristone + Misoprostol (13 - 22 Weeks)
- Conditions
- Interventions
- First Posted Date
- 2013-01-15
- Last Posted Date
- 2014-05-14
- Lead Sponsor
- Gynuity Health Projects
- Target Recruit Count
- 504
- Registration Number
- NCT01768299
- Locations
- 🇻🇳
National Ob-Gyn Hospital, Hanoi, Vietnam
🇻🇳Hung Vuong Hospital, Ho Chi Minh City, Vietnam
🇻🇳Binh duong Obstetrics and Newborn Hospital, Ho Chi Minh City, Binh Duong Province, Vietnam
Comparison Between 25 µg Vaginal Misoprostol vs Slow Release Pessary PGE2
- First Posted Date
- 2013-01-10
- Last Posted Date
- 2016-04-28
- Lead Sponsor
- University Hospital, Toulouse
- Target Recruit Count
- 1700
- Registration Number
- NCT01765881
- Locations
- 🇫🇷
Bicêtre Hospital, Le Kremlin-Bicêtre, France
🇫🇷Hospital Poissy, Poissy, France
🇫🇷Hôpitaux Universitaires de Strasbourg, Strasbourg, France
Cervical Ripening Before Endometrial Biopsy in Abnormal Uterine Bleeding Using Sublingual Misoprostol
- Conditions
- Interventions
- First Posted Date
- 2013-01-07
- Last Posted Date
- 2013-01-07
- Lead Sponsor
- Mahidol University
- Target Recruit Count
- 52
- Registration Number
- NCT01762319
- Locations
- 🇹🇭
Faculty of Medicine Siriraj Hospital Mahidol University, Bangkok, Thailand
Use of Misoprostol in Case of Insertion Failure of Intrauterine Contraceptives
- First Posted Date
- 2012-12-21
- Last Posted Date
- 2015-06-04
- Lead Sponsor
- Luis Bahamondes
- Target Recruit Count
- 102
- Registration Number
- NCT01754649
- Locations
- 🇧🇷
Family Planning Clinic, University of Campinas, Campinas, SP, Brazil
🇧🇷University of Campinas, Campinas, SP, Brazil
Drug Development Updates
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