Misoprostol
- Generic Name
- Misoprostol
- Brand Names
- Arthrotec, Cytotec, Mifegymiso
- Drug Type
- Small Molecule
- Chemical Formula
- C22H38O5
- CAS Number
- 59122-46-2
- Unique Ingredient Identifier
- 0E43V0BB57
- Background
Misoprostol is a prostaglandin analog used to reduce the risk of NSAID related ulcers, manage miscarriages, prevent post partum hemorrhage, and also for first trimester abortions. The stimulation of prostaglandin receptors in the stomach reduces gastric acid secretion, while stimulating these receptors in the uterus and cervix can increase the strength and frequency of contractions and decrease cervical tone.
Misoprostol was granted FDA approval on 27 December 1988.
- Indication
Misoprostol is indicated as a tablet to reduce the risk of NSAID induced gastric ulcers but not duodenal ulcers in high risk patients. Misoprostol is also formulated in combination with diclofenac to treat symptoms of osteoarthritis or rheumatoid arthritis in patients with a high risk of developing gastric ulcers. Misoprostol is used off label for the management of miscarriages, prevention of post partum hemorrhage, and is also used alone or in combination with mifepristone in other countries for first trimester abortions.
- Associated Conditions
- Gastric Ulcer, Incomplete Abortion, Missed Abortion, Postpartum Haemorrhage (PPH)
- Associated Therapies
- Induction of cervix ripening therapy, Medically induced abortion
Cervical Preparation Before Dilation and Evacuation
- Conditions
- Interventions
- First Posted Date
- 2012-12-17
- Last Posted Date
- 2016-02-24
- Lead Sponsor
- Planned Parenthood League of Massachusetts
- Target Recruit Count
- 300
- Registration Number
- NCT01751087
- Locations
- 🇺🇸
Family Planning Associates, Chicago, Illinois, United States
🇺🇸Planned Parenthood of New York City, New York, New York, United States
🇺🇸Lovejoy Surgical Center, Portland, Oregon, United States
Buccal Misoprostol During Cesarean Section for Preventing Postpartum Hemorrhage
- First Posted Date
- 2012-11-27
- Last Posted Date
- 2018-10-11
- Lead Sponsor
- Hospital Universitario Dr. Jose E. Gonzalez
- Target Recruit Count
- 123
- Registration Number
- NCT01733329
- Locations
- 🇲🇽
Hospital Universitario Dr. José Eleuterio González, Monterrey, Nuevo León, Mexico
Comparing Misoprostol and Oxytocin in Uniject for Postpartum Hemorrhage (PPH) Prevention in Senegal
- Conditions
- Interventions
- First Posted Date
- 2012-10-24
- Last Posted Date
- 2016-02-25
- Lead Sponsor
- Gynuity Health Projects
- Target Recruit Count
- 1365
- Registration Number
- NCT01713153
- Locations
- 🇸🇳
Health huts in the district of Thiadiaye and Kolda, Thiadiay and Kolda, Thiadiaye and Kolda, Senegal
Misoprostol and Oxytocin in Uniject® for Postpartum Hemorrhage Prevention in Communities
- First Posted Date
- 2012-10-19
- Last Posted Date
- 2016-02-15
- Lead Sponsor
- Gynuity Health Projects
- Registration Number
- NCT01710566
In Vitro Myometrial Contractions in Laboring and Non-laboring Women
- Conditions
- Interventions
- First Posted Date
- 2012-09-21
- Last Posted Date
- 2012-09-21
- Target Recruit Count
- 53
- Registration Number
- NCT01689311
- Locations
- 🇨🇦
Mount Sinai Hospital, Toronto, Ontario, Canada
Comparison of Laminaria and Misoprostol for Cervical Preparation Before Second Trimester Surgical Abortion
- Conditions
- Interventions
- First Posted Date
- 2012-09-05
- Last Posted Date
- 2012-09-05
- Lead Sponsor
- Wolfson Medical Center
- Target Recruit Count
- 84
- Registration Number
- NCT01678703
- Locations
- 🇮🇱
Edith Wolfson Medical Center, Holon, Israel
Mifepristone Versus Misoprostol for Cervical Preparation Prior to Surgical Abortion Between 11 to 15 Weeks
- Conditions
- Interventions
- First Posted Date
- 2012-07-10
- Last Posted Date
- 2017-05-22
- Lead Sponsor
- Boston University
- Target Recruit Count
- 42
- Registration Number
- NCT01636063
- Locations
- 🇺🇸
Boston University Medical Center, Boston, Massachusetts, United States
Intravaginal Misoprostol Versus Dinoprostone Before Diagnostik Hysteroscopy
- First Posted Date
- 2012-06-15
- Last Posted Date
- 2012-08-07
- Target Recruit Count
- 30
- Registration Number
- NCT01620814
- Locations
- 🇹🇷
Zekai Tahir Burak Women Health Education Research Hospital, Ankara, Turkey
Value of Mifepristone in Cervical Preparation Prior to Dilation and Evacuation 19-24 Weeks
- Conditions
- Interventions
- First Posted Date
- 2012-06-11
- Last Posted Date
- 2024-02-13
- Lead Sponsor
- Stanford University
- Target Recruit Count
- 50
- Registration Number
- NCT01615731
- Locations
- 🇺🇸
Santa Clara Valley Medical Center, San Jose, California, United States
🇺🇸Stanford University Medical Center, Stanford, California, United States
Repeated Doses of Misoprostol for Medical Treatment of Missed Miscarriage
- First Posted Date
- 2012-06-08
- Last Posted Date
- 2019-12-18
- Lead Sponsor
- Kristina Gemzell Danielsson
- Target Recruit Count
- 23
- Registration Number
- NCT01615224
- Locations
- 🇸🇪
Dept of Obstetrics and Gynecology, Danderyd Hospital, Stockholm, Sweden
Drug Development Updates
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