Misoprostol

Generic Name: Misoprostol

Brand Names: Arthrotec, Cytotec, Mifegymiso

Drug Type: Small Molecule

Chemical Formula: C_₂₂H_₃₈O_₅

CAS Number: 59122-46-2

Unique Ingredient Identifier: 0E43V0BB57

Background: Misoprostol is a prostaglandin analog used to reduce the risk of NSAID related ulcers, manage miscarriages, prevent post partum hemorrhage, and also for first trimester abortions. The stimulation of prostaglandin receptors in the stomach reduces gastric acid secretion, while stimulating these receptors in the uterus and cervix can increase the strength and f...

Indication: Misoprostol is indicated as a tablet to reduce the risk of NSAID induced gastric ulcers but not duodenal ulcers in high risk patients. Misoprostol is also formulated in combination with diclofenac to treat symptoms of osteoarthritis or rheumatoid arthritis in patients with a high risk of developing gastric ulcers. Misoprostol is used off label for the manage...

Associated Conditions: Gastric Ulcer, Incomplete Abortion, Missed Abortion, Postpartum Haemorrhage (PPH)

Associated Therapies: Induction of cervix ripening therapy, Medically induced abortion

Clinical Trials

Optimal Treatment of Miscarriage

Not Applicable

Completed

Conditions: Abortion, Spontaneous

Interventions: Drug: misoprostol

First Posted Date: 2009-12-17

Last Posted Date: 2018-10-22

Lead Sponsor: Region Skane

Target Recruit Count: 190

Registration Number: NCT01033903

Locations: 🇸🇪
Region Skane, Kvinnokliniken, University Hopsital MAS, Malmö, Sweden

Cervical Priming With Misoprostol Prior to Operative Hysteroscopy

Phase 3

Completed

Conditions: Cervical Ripening

Interventions: Drug: Misoprostol

First Posted Date: 2009-12-02

Last Posted Date: 2009-12-02

Lead Sponsor: Samsung Medical Center

Target Recruit Count: 141

Registration Number: NCT01024270

Locations: 🇰🇷
Samsung Medical Center, Seoul, Korea, Republic of

Use of Misoprostol for Intrauterine Device (IUD) Insertion in Nulliparous Women

Not Applicable

Completed

Conditions: Contraception

Interventions: Drug: Placebo
Drug: Misoprostol

First Posted Date: 2009-10-27

Last Posted Date: 2012-06-14

Lead Sponsor: University of Arizona

Target Recruit Count: 61

Registration Number: NCT01001897

Locations: 🇺🇸
UPH-Kino multispecialty clinic, Tucson, Arizona, United States
🇺🇸
University Medical Center Ob/Gyn clinic 8OPC, Tucson, Arizona, United States

Oral Titrated Misoprostol for Induction of Labour

Not Applicable

Completed

Conditions: Labor, Induced

Interventions: Drug: Misoprostol

First Posted Date: 2009-10-09

Last Posted Date: 2011-06-23

Lead Sponsor: Instituto Materno Infantil Prof. Fernando Figueira

Target Recruit Count: 400

Registration Number: NCT00992524

Locations: 🇧🇷
Instituto de Medicina Integral Professor Fernando Figueira (IMIP), Recife, Pernambuco, Brazil

Vaginal Misoprostol for Cervical Ripening Prior to Endometrial Biopsy

Phase 3

Withdrawn

Conditions: Menorrhagia
Endometrial Biopsy
Cervical Ripening

Interventions: Drug: Misoprostol
Drug: Placebo

First Posted Date: 2009-08-06

Last Posted Date: 2012-08-14

Lead Sponsor: University of Saskatchewan

Registration Number: NCT00953641

Locations: 🇨🇦
Obstetrics and Gynecologic Consultants, Saskatoon, Saskatchewan, Canada

Misoprostol for Second Trimester Termination of Pregnancy

Not Applicable

Completed

Conditions: Termination of Pregnancy Second Trimester

Interventions: Drug: misoprostol

First Posted Date: 2009-07-24

Last Posted Date: 2009-07-24

Lead Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Target Recruit Count: 176

Registration Number: NCT00945997

Locations: 🇳🇱
Academic Medical Center, Amsterdam, Netherlands

Efficacy and Safety Study of the Misoprostol Vaginal Priming Insert (MVPI) Prior to Hysteroscopy

Phase 2

Completed

Conditions: Cervical Priming

Interventions: Drug: placebo
Drug: misoprostol

First Posted Date: 2009-06-22

Last Posted Date: 2014-02-13

Lead Sponsor: Ferring Pharmaceuticals

Target Recruit Count: 51

Registration Number: NCT00925938

Locations: 🇺🇸
Lyndhurst Gynecologic Associates, Winston-Salem, North Carolina, United States
🇺🇸
Precision Trials, Phoenix, Arizona, United States

Oral Misoprostol for Labor Augmentation: A Pilot Study

Phase 1

Completed

Conditions: Arrest of Dilation in Labor

Interventions: Drug: Misoprostol

First Posted Date: 2009-05-21

Last Posted Date: 2009-05-21

Lead Sponsor: University of Texas Southwestern Medical Center

Target Recruit Count: 46

Registration Number: NCT00906126

Locations: 🇺🇸
University of Texas Southwestern Medical Center, Dallas, Texas, United States

A Trial of Oral Misoprostol for Labor Augmentation

Phase 4

Completed

Conditions: Labor Augmentation

Interventions: Drug: Oxytocin
Drug: Misoprostol

First Posted Date: 2009-05-21

Last Posted Date: 2012-11-15

Lead Sponsor: University of Texas Southwestern Medical Center

Target Recruit Count: 350

Registration Number: NCT00906347

Locations: 🇺🇸
The University of Texas Southwestern Medical Center, Dallas, Texas, United States

The Comparison of Efficacy for Cervical Ripening in Labor Induction Between Titrated and Conventional Oral Misoprostol

Phase 4

Completed

Conditions: Cervical Ripening
Labor Induction

Interventions: Drug: misoprostol

First Posted Date: 2009-04-23

Last Posted Date: 2010-07-14

Lead Sponsor: Mahidol University

Target Recruit Count: 64

Registration Number: NCT00886860

Locations: 🇹🇭
Siriraj Hospital, Mahidol University, Bangkok, Thailand

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