Misoprostol
- Generic Name
- Misoprostol
- Brand Names
- Arthrotec, Cytotec, Mifegymiso
- Drug Type
- Small Molecule
- Chemical Formula
- C22H38O5
- CAS Number
- 59122-46-2
- Unique Ingredient Identifier
- 0E43V0BB57
- Background
Misoprostol is a prostaglandin analog used to reduce the risk of NSAID related ulcers, manage miscarriages, prevent post partum hemorrhage, and also for first trimester abortions. The stimulation of prostaglandin receptors in the stomach reduces gastric acid secretion, while stimulating these receptors in the uterus and cervix can increase the strength and frequency of contractions and decrease cervical tone.
Misoprostol was granted FDA approval on 27 December 1988.
- Indication
Misoprostol is indicated as a tablet to reduce the risk of NSAID induced gastric ulcers but not duodenal ulcers in high risk patients. Misoprostol is also formulated in combination with diclofenac to treat symptoms of osteoarthritis or rheumatoid arthritis in patients with a high risk of developing gastric ulcers. Misoprostol is used off label for the management of miscarriages, prevention of post partum hemorrhage, and is also used alone or in combination with mifepristone in other countries for first trimester abortions.
- Associated Conditions
- Gastric Ulcer, Incomplete Abortion, Missed Abortion, Postpartum Haemorrhage (PPH)
- Associated Therapies
- Induction of cervix ripening therapy, Medically induced abortion
A Randomized Trial of Two Regimens of Misoprostol for Second Trimester Termination for Intrauterine Fetal Death
- First Posted Date
- 2005-09-02
- Last Posted Date
- 2013-07-19
- Lead Sponsor
- American University of Beirut Medical Center
- Target Recruit Count
- 73
- Registration Number
- NCT00141895
- Locations
- 🇱🇧
American University of Beirut Medical Center, Beirut, Lebanon
Sublingual Versus Vaginal Misoprostol for Labor Induction at Term
- First Posted Date
- 2005-09-01
- Last Posted Date
- 2012-07-13
- Lead Sponsor
- American University of Beirut Medical Center
- Target Recruit Count
- 170
- Registration Number
- NCT00140114
- Locations
- 🇱🇧
American University of Beirut Medical Center, Beirut, Lebanon
Comparing Methotrexate Followed by Misoprostol to Misoprostol Alone for Early Abortion
- Conditions
- Unwanted Pregnancies
- First Posted Date
- 2005-08-11
- Last Posted Date
- 2018-06-11
- Lead Sponsor
- Wiebe, Ellen, M.D.
- Target Recruit Count
- 300
- Registration Number
- NCT00129506
- Locations
- 🇨🇦
Wiebe Early Abortion Clinic, Vancouver, British Columbia, Canada
Misoprostol for Preventing Postpartum Hemorrhage
- First Posted Date
- 2005-07-28
- Last Posted Date
- 2008-05-28
- Lead Sponsor
- Gynuity Health Projects
- Target Recruit Count
- 1200
- Registration Number
- NCT00124540
- Locations
- 🇺🇬
Mulago Hospital, Kampala, Uganda
🇿🇦Rob Ferreira Hospital, Nelspruit, South Africa
🇿🇦Dora Nginza Hospital, Port Elizabeth, South Africa
Misoprostol for the Prevention of Postpartum Hemorrhage in Rural Pakistan
- Conditions
- Postpartum HemorrhageAnemia
- First Posted Date
- 2005-07-15
- Last Posted Date
- 2009-03-19
- Lead Sponsor
- Gynuity Health Projects
- Target Recruit Count
- 1600
- Registration Number
- NCT00120237
- Locations
- 🇵🇰
Home delivery setting, Chitral, Chitral District, Pakistan
Optimisation of the Management of Placental Delivery in Second Trimester Pregnancy Interruption
- Conditions
- Placenta, RetainedPostpartum Hemorrhage
- Interventions
- First Posted Date
- 2005-07-14
- Last Posted Date
- 2009-07-09
- Lead Sponsor
- The University of Western Australia
- Target Recruit Count
- 251
- Registration Number
- NCT00120042
- Locations
- 🇦🇺
King Edward Memorial Hospital, Perth, Western Australia, Australia
Misoprostol in the Treatment of Postpartum Hemorrhage
- First Posted Date
- 2005-06-30
- Last Posted Date
- 2009-03-19
- Lead Sponsor
- Gynuity Health Projects
- Target Recruit Count
- 61
- Registration Number
- NCT00116480
- Locations
- 🇵🇰
The Aga Khan Health Services, Karachi, Pakistan
🇵🇰Aga Khan University Hospital, Karachi, Pakistan
Misoprostol for the Treatment of Postpartum Hemorrhage
- First Posted Date
- 2005-06-29
- Last Posted Date
- 2009-03-19
- Lead Sponsor
- Gynuity Health Projects
- Target Recruit Count
- 1786
- Registration Number
- NCT00116350
- Locations
- 🇹🇷
Ministry of Health Ankara Etlik Maternity and Teaching-Research Hospital, Ankara, Turkey
🇪🇨Hospital Gineco-Obstetrico Isidro Ayora, Quito, Ecuador
🇧🇫Centre Hospitalier Universitaire Souro Sanou de Bobo Dioulasso, Bobo Diolasso, Burkina Faso
Oral Misoprostol Versus Intravenous Oxytocin in Preventing Blood Loss After Non-scheduled Cesarean Section
- Conditions
- Postpartum Hemorrhage
- First Posted Date
- 2005-04-12
- Last Posted Date
- 2019-04-04
- Lead Sponsor
- University Hospital, Basel, Switzerland
- Target Recruit Count
- 56
- Registration Number
- NCT00107874
- Locations
- 🇨🇭
Women's University Hospital, Basel, Basel, Switzerland
RCT of Misoprostol for Postpartum Hemorrhage in India
- Conditions
- Postpartum HemorrhagePregnancy
- First Posted Date
- 2004-11-18
- Last Posted Date
- 2014-07-31
- Lead Sponsor
- NICHD Global Network for Women's and Children's Health
- Target Recruit Count
- 1600
- Registration Number
- NCT00097123
- Locations
- 🇮🇳
KLE Society's Jawaharlal Nehru Medical College, Belgaum, Karnataka, India
Drug Development Updates
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