Misoprostol
- Generic Name
- Misoprostol
- Brand Names
- Arthrotec, Cytotec, Mifegymiso
- Drug Type
- Small Molecule
- Chemical Formula
- C22H38O5
- CAS Number
- 59122-46-2
- Unique Ingredient Identifier
- 0E43V0BB57
- Background
Misoprostol is a prostaglandin analog used to reduce the risk of NSAID related ulcers, manage miscarriages, prevent post partum hemorrhage, and also for first trimester abortions. The stimulation of prostaglandin receptors in the stomach reduces gastric acid secretion, while stimulating these receptors in the uterus and cervix can increase the strength and frequency of contractions and decrease cervical tone.
Misoprostol was granted FDA approval on 27 December 1988.
- Indication
Misoprostol is indicated as a tablet to reduce the risk of NSAID induced gastric ulcers but not duodenal ulcers in high risk patients. Misoprostol is also formulated in combination with diclofenac to treat symptoms of osteoarthritis or rheumatoid arthritis in patients with a high risk of developing gastric ulcers. Misoprostol is used off label for the management of miscarriages, prevention of post partum hemorrhage, and is also used alone or in combination with mifepristone in other countries for first trimester abortions.
- Associated Conditions
- Gastric Ulcer, Incomplete Abortion, Missed Abortion, Postpartum Haemorrhage (PPH)
- Associated Therapies
- Induction of cervix ripening therapy, Medically induced abortion
Misoprostol in Termination of First Trimester Missed Abortion
- Conditions
- Miscarriage
- Interventions
- First Posted Date
- 2008-11-25
- Last Posted Date
- 2008-11-25
- Lead Sponsor
- Hawler Medical University
- Target Recruit Count
- 100
- Registration Number
- NCT00797693
- Locations
- 🇮🇶
Maternity Teaching Hospital, Erbil, Hawler, Iraq
Mifepristone and Misoprostol Versus Misoprostol Alone for Mid-trimester Termination of Pregnancy (14 - 21 Weeks LMP): A Randomized-controlled Double-blinded Trial
- Conditions
- Abortion, Induced
- Interventions
- First Posted Date
- 2008-11-02
- Last Posted Date
- 2014-02-20
- Lead Sponsor
- Gynuity Health Projects
- Target Recruit Count
- 120
- Registration Number
- NCT00784186
- Locations
- 🇻🇳
National Ob-Gyn Hospital, Hanoi, Vietnam
🇻🇳Hung Vuong Hospital, Ho Chi Minh City, Vietnam
Efficacy and Safety Study of Titrated Oral Misoprostol Solution for Labor Augmentation
- First Posted Date
- 2008-06-11
- Last Posted Date
- 2008-07-10
- Lead Sponsor
- China Medical University Hospital
- Target Recruit Count
- 143
- Registration Number
- NCT00695331
- Locations
- 🇨🇳
Labor Unit, Department of Obstetric and Gynecology, China Medical Univertiy Hospital, Taichung, Taiwan
Comparing Two Regimens for Medical Abortion: Mifepristone+Misoprostol Versus Misoprostol Alone
- Conditions
- Pregnancy Termination
- Interventions
- First Posted Date
- 2008-05-20
- Last Posted Date
- 2013-03-13
- Lead Sponsor
- Gynuity Health Projects
- Target Recruit Count
- 440
- Registration Number
- NCT00680394
- Locations
- 🇹🇳
La Rabta Hospital, Tunis, Tunisia
🇻🇳Hung Vuong Hospital, Ho Chi Minh City, Vietnam
Medical Abortion for Emergency Contraception Failure
- Conditions
- Emergency ContraceptionAbortion, Induced
- Interventions
- First Posted Date
- 2008-05-14
- Last Posted Date
- 2008-05-16
- Lead Sponsor
- Taizhou Hospital
- Target Recruit Count
- 394
- Registration Number
- NCT00677755
- Locations
- 🇨🇳
Taizhou Hospital of zhejiang Province, Taizhou City, Zhejiang, China
Treatment of Incomplete Abortion With 600 Mcg Oral Misoprostol Compared to Standard Surgical Treatment
- Conditions
- Incomplete Abortion
- Interventions
- Procedure: Surgical treatment
- First Posted Date
- 2008-05-07
- Last Posted Date
- 2008-05-07
- Lead Sponsor
- Gynuity Health Projects
- Target Recruit Count
- 311
- Registration Number
- NCT00674232
- Locations
- 🇪🇨
Hospital Gineco-obstetrico Isidro Ayora, Quito, Ecuador
🇪🇨Hospital del Dia, CEMOPLAF, Quito, Ecuador
🇻🇪Hospital Maternidad Concepcion Palacios, Caracas, Venezuela
Misoprostol for the Treatment of Incomplete Abortion
- First Posted Date
- 2008-05-02
- Last Posted Date
- 2016-07-27
- Lead Sponsor
- Gynuity Health Projects
- Target Recruit Count
- 720
- Registration Number
- NCT00670761
- Locations
- 🇹🇿
Kagera Regional Hospital, Bukoba, Tanzania
🇧🇫Hôpital de District Sanitaire Dandé, Bobo Dioulasso, Burkina Faso
🇲🇬Befelatanana Maternity Centre, Antananarivo, Madagascar
Misoprostol for Treatment of Fetal Death at 14-28 Weeks of Pregnancy
- First Posted Date
- 2008-05-02
- Last Posted Date
- 2013-05-08
- Lead Sponsor
- Gynuity Health Projects
- Target Recruit Count
- 153
- Registration Number
- NCT00671060
- Locations
- 🇺🇸
University of Illinois at Chicago, Chicago, Illinois, United States
🇺🇸Christiana Care Health System, Newark, Delaware, United States
🇻🇳Huong Vuong Hospital, Ho Chi Minh City, Vietnam
Misoprostol With Intrauterine Device Insertion
- Conditions
- Contraception
- Interventions
- Dietary Supplement: Magnesium Oxide
- First Posted Date
- 2008-02-13
- Last Posted Date
- 2013-03-15
- Lead Sponsor
- Oregon Health and Science University
- Target Recruit Count
- 40
- Registration Number
- NCT00613366
- Locations
- 🇺🇸
Planned Parenthood of the Columbia Willamette, Portland, Oregon, United States
🇺🇸Oregon Health & Science University, Portland, Oregon, United States
Labour Induction With Misoprostol, Dinoprostone and Bard Catheter
- Conditions
- Pregnancy
- Interventions
- First Posted Date
- 2008-01-28
- Last Posted Date
- 2008-01-28
- Lead Sponsor
- Karolinska University Hospital
- Target Recruit Count
- 592
- Registration Number
- NCT00602095
Drug Development Updates
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