Overview
Ephedrine was first described in western literature in 1888, as a naturally occurring component of the ephedra plant, along with pseudoephedrine. Ephedrine acts as both a direct and indirect sympathomimetic. It is an alpha- and beta-adrenergic receptor agonist; however, it also causes the indirect release of norepinephrine from sympathetic neurons, inhibiting norepinephrine reuptake and displacing more norepinephrine from storage vesicles. Ephedrine is used for its vasoconstrictive, positive chronotropic, and positive inotropic effects. Ephedrine and phenylephrine are still used to treat hypotension, but their use in other indications has decreased due to the development of more selective adrenergic agonists. Ephedrine was granted a type 7 FDA Approval on 29 April 2016.
Indication
Ephedrine intravenous injections are indicated to treat hypotension under anesthesia, ephedrine injections by multiple routes are indicated to treat allergic conditions such as bronchial asthma, ephedrine nasal spray is and OTC medication used as a decongestant.
Associated Conditions
- Allergic Reaction
- Bronchial Asthma
- Common Cold
- Cough
- Depression
- Fever
- General Anesthesia Induced Hypotension
- Headache
- Joint Pain
- Myasthenia Gravis
- Narcolepsy
- Nasal Congestion
- Rhinorrhoea
- Sore Throat
- Dry cough
Clinical Trials
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Title | Posted | Study ID | Phase | Status | Sponsor |
|---|---|---|---|---|---|
2010/11/19 | Phase 4 | Terminated | University College London Hospitals | ||
2010/08/23 | Phase 1 | Completed | |||
2009/11/18 | Not Applicable | Completed | Bayside Health | ||
2009/11/03 | Phase 2 | Completed | |||
2007/10/10 | Phase 1 | UNKNOWN | |||
2007/04/09 | Not Applicable | Completed | |||
2007/02/09 | Phase 2 | Completed | |||
2006/09/19 | Phase 2 | Completed | |||
2005/09/07 | Phase 3 | UNKNOWN |
FDA Drug Approvals
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|---|---|---|---|---|---|
| No FDA approvals found for this drug. | |||||
EMA Drug Approvals
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|---|---|---|---|
| No EMA approvals found for this drug. | |||
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PPB Drug Approvals
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Approved Product | Registration No. | Company | Licence No. | Strength | Registration Date |
|---|---|---|---|---|---|
| LROSEDYL COUGH SYRUP | N/A | N/A | N/A | 2/8/2019 | |
| ALSEDYL SYRUP | N/A | N/A | N/A | 5/30/2001 | |
| TROSEDYL COUGH SYRUP | N/A | N/A | N/A | 2/8/2019 | |
| COSOTAL FORTE COUGH SYRUP | N/A | N/A | N/A | 3/1/1999 | |
| PHENAZOL COUGH SYRUP | N/A | N/A | N/A | 10/7/1998 | |
| BROSEDYL COUGH SYRUP | N/A | N/A | N/A | 2/8/2019 | |
| CODEY SYRUP | N/A | N/A | N/A | 7/28/2001 | |
| GOBY COUGH SYRUP | N/A | N/A | N/A | 3/16/2011 | |
| P.E.C. SYRUP | N/A | N/A | N/A | 6/14/1979 | |
| VECOL COUGH SYRUP | N/A | N/A | N/A | 2/15/2019 |
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