Ephedrine
- Generic Name
- Ephedrine
- Brand Names
- Akovaz, Bronkaid, Corphedra, Emerphed, Primatene, Rezipres
- Drug Type
- Small Molecule
- Chemical Formula
- C10H15NO
- CAS Number
- 299-42-3
- Unique Ingredient Identifier
- GN83C131XS
- Background
Ephedrine was first described in western literature in 1888, as a naturally occurring component of the ephedra plant, along with pseudoephedrine. Ephedrine acts as both a direct and indirect sympathomimetic. It is an alpha- and beta-adrenergic receptor agonist; however, it also causes the indirect release of norepinephrine from sympathetic neurons, inhibiting norepinephrine reuptake and displacing more norepinephrine from storage vesicles. Ephedrine is used for its vasoconstrictive, positive chronotropic, and positive inotropic effects. Ephedrine and phenylephrine are still used to treat hypotension, but their use in other indications has decreased due to the development of more selective adrenergic agonists. Ephedrine was granted a type 7 FDA Approval on 29 April 2016.
- Indication
Ephedrine intravenous injections are indicated to treat hypotension under anesthesia, ephedrine injections by multiple routes are indicated to treat allergic conditions such as bronchial asthma, ephedrine nasal spray is and OTC medication used as a decongestant.
- Associated Conditions
- Allergic Reaction, Bronchial Asthma, Common Cold, Cough, Depression, Fever, General Anesthesia Induced Hypotension, Headache, Joint Pain, Myasthenia Gravis, Narcolepsy, Nasal Congestion, Rhinorrhoea, Sore Throat, Dry cough
- Associated Therapies
- -
Ephedrine Versus Phenylephrine for Spinal Block - Related Hypotension in Cesarean Delivery
- Conditions
- Spinal AnesthesiaCesarean DeliveryNeonatal Acidosis
- Interventions
- First Posted Date
- 2024-12-19
- Last Posted Date
- 2024-12-19
- Lead Sponsor
- Centre of Postgraduate Medical Education
- Target Recruit Count
- 80
- Registration Number
- NCT06741410
- Locations
- 🇵🇱
Centre of Postgraduate Medical Education,Department of Anesthesia and Intensive Care, Warsaw, Poland
Ephedrine Doses to Prevent Maternal Hypotension After Spinal Anesthesia in Cesarean Section
- Conditions
- Hypotension After Spinal AnesthesiaHypotension During Cesarean Delivery
- Interventions
- Drug: Normal Saline (Placebo)Drug: Ephedrine
- First Posted Date
- 2024-10-31
- Last Posted Date
- 2024-10-31
- Lead Sponsor
- B.P. Koirala Institute of Health Sciences
- Target Recruit Count
- 120
- Registration Number
- NCT06668337
- Locations
- 🇳🇵
B.P. koirala Institute of Health Sciences, Dharan, Nepal
Management of Postspinal Anesthesia Hypotension During Elective Cesarean Section: Baby Norepinephrine Versus Ephedrine
- Conditions
- Anesthesia ComplicationVasopressorCesarean Section ComplicationsHypotension During Surgery
- Interventions
- First Posted Date
- 2024-07-12
- Last Posted Date
- 2024-10-23
- Lead Sponsor
- Hopital Charles Nicolle
- Target Recruit Count
- 126
- Registration Number
- NCT06498076
- Locations
- 🇹🇳
Charles Nicolle Hospital, Tunis, Tunisia
Dexmedetomidine Infusion Dose Versus Rapid Bolus Dose Before Tracheal Intubation.
- Conditions
- DexmedetomidineIntubation Complication
- Interventions
- First Posted Date
- 2024-03-25
- Last Posted Date
- 2024-03-25
- Lead Sponsor
- Kasr El Aini Hospital
- Target Recruit Count
- 70
- Registration Number
- NCT06327399
- Locations
- 🇪🇬
Cairo University Hospitals, Giza, Egypt
Effect of Ephedrine, Phenylepinephrine, and Norepinephrine on Myometrial Contractility in Pregnant People With Type II and Gestational Diabetes During Cesarean Section: An In-vitro Study
- Conditions
- Postpartum Hemorrhage
- Interventions
- First Posted Date
- 2024-02-29
- Last Posted Date
- 2024-04-12
- Lead Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
- Target Recruit Count
- 24
- Registration Number
- NCT06285396
- Locations
- 🇨🇦
Mount Sinai Hospital, Toronto, Ontario, Canada
Could Ephedrine Replace Dexmedetomidine Fordexmedetomidine Prevention of Shivering in Women Undergoing Cesarean Section Under Spinal Anaesthesia
- Conditions
- Prevention of Shivering With Spinal Anaesthesia
- Interventions
- First Posted Date
- 2024-01-31
- Last Posted Date
- 2024-01-31
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 200
- Registration Number
- NCT06233032
- Locations
- 🇪🇬
Assiut university, Assiut, Egypt
Cerebral Flow-metabolism Coupling During Adult Surgery
- Conditions
- Anesthesia
- Interventions
- First Posted Date
- 2023-07-12
- Last Posted Date
- 2023-10-18
- Lead Sponsor
- Jason Chui
- Target Recruit Count
- 80
- Registration Number
- NCT05941494
- Locations
- 🇨🇦
London Health Sciences Centre, London, Ontario, Canada
The Effect of Low-dose Atropine on Sympathetic Blockade in Spinal Cesarean Section Patients
- Conditions
- Anesthesia, SpinalPregnancyCesarean Section
- Interventions
- Drug: Slow dose preemptive AtropineDrug: Ephedrine
- First Posted Date
- 2023-06-07
- Last Posted Date
- 2023-10-11
- Lead Sponsor
- Abant Izzet Baysal University
- Target Recruit Count
- 60
- Registration Number
- NCT05892913
- Locations
- 🇹🇷
Bolu Abant Izzet Baysal university Medical School, Anesthesiology and Reanimation D., Bolu, Turkey
Impact of Prophylactic Ephedrine on Fetal Heart Tracing and Uterine Tetanic Contraction After CSE
- First Posted Date
- 2023-05-24
- Last Posted Date
- 2024-05-08
- Lead Sponsor
- Icahn School of Medicine at Mount Sinai
- Target Recruit Count
- 150
- Registration Number
- NCT05873218
- Locations
- 🇺🇸
Icahn School of Medicine at Mount SInai, New York, New York, United States
Intubation Conditions After RSI Using Rocuronium with Ephedrine Pretreatment
- Conditions
- Rapid Sequence Induction and Intubation
- Interventions
- First Posted Date
- 2023-02-13
- Last Posted Date
- 2024-10-14
- Lead Sponsor
- Ain Shams University
- Target Recruit Count
- 75
- Registration Number
- NCT05725031
- Locations
- 🇪🇬
Ain Shams University Hospitals, Cairo, Egypt
Drug Development Updates
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