Ephedrine

Generic Name: Ephedrine

Brand Names: Akovaz, Bronkaid, Corphedra, Emerphed, Primatene, Rezipres

Drug Type: Small Molecule

Chemical Formula: C_₁₀H_₁₅NO

CAS Number: 299-42-3

Unique Ingredient Identifier: GN83C131XS

Background: Ephedrine was first described in western literature in 1888, as a naturally occurring component of the ephedra plant, along with pseudoephedrine. Ephedrine acts as both a direct and indirect sympathomimetic. It is an alpha- and beta-adrenergic receptor agonist; however, it also causes the indirect release of norepinephrine from sympathetic neurons, inhibiting norepinephrine reuptake and displacing more norepinephrine from storage vesicles. Ephedrine is used for its vasoconstrictive, positive chronotropic, and positive inotropic effects. Ephedrine and phenylephrine are still used to treat hypotension, but their use in other indications has decreased due to the development of more selective adrenergic agonists. Ephedrine was granted a type 7 FDA Approval on 29 April 2016.

Indication: Ephedrine intravenous injections are indicated to treat hypotension under anesthesia, ephedrine injections by multiple routes are indicated to treat allergic conditions such as bronchial asthma, ephedrine nasal spray is and OTC medication used as a decongestant.

Associated Conditions: Allergic Reaction, Bronchial Asthma, Common Cold, Cough, Depression, Fever, General Anesthesia Induced Hypotension, Headache, Joint Pain, Myasthenia Gravis, Narcolepsy, Nasal Congestion, Rhinorrhoea, Sore Throat, Dry cough

Clinical Trials

Effect of Ephedrine vs. Norepinephrine on Prevention of Fetal Acidosis During Cesarean Section Under Spinal Anesthesia

Phase 4

Not yet recruiting

Conditions: Acidosis, Lactic
Hypotension After Spinal Anesthesia
Cesarean Delivery Affecting Newborn

Interventions: Drug: Ephedrine
Drug: Norepinephrine

First Posted Date: 2025-04-10

Last Posted Date: 2025-05-16

Lead Sponsor: mehmet özkılıç

Target Recruit Count: 100

Registration Number: NCT06921473

Postoperative Delirium After Intraoperative Ephedrine Versus Norepinephrine

Not yet recruiting

Conditions: Ephedrine
Norepinephrine
Postoperative Delirium (POD)

Interventions: Drug: Ephedrine
Drug: Norepinephrine

First Posted Date: 2025-02-25

Last Posted Date: 2025-02-25

Lead Sponsor: Riverside University Health System Medical Center

Target Recruit Count: 10000

Registration Number: NCT06844201

Evaluation of Post-Induction Hypotension Treatment with PRAM Method

Active, not recruiting

Conditions: Hypotension on Induction

Interventions: Drug: Ephedrine
Drug: Noradrenalin

First Posted Date: 2025-01-22

Last Posted Date: 2025-03-05

Lead Sponsor: Ankara City Hospital Bilkent

Target Recruit Count: 100

Registration Number: NCT06787404

Locations: 🇹🇷
Ankara Bilkent Şehir Hastanesi, Ankara, Turkey

Ephedrine Versus Phenylephrine for Spinal Block - Related Hypotension in Cesarean Delivery

Active, not recruiting

Conditions: Spinal Anesthesia
Cesarean Delivery
Neonatal Acidosis

Interventions: Drug: Ephedrine
Drug: Phenylephrine

First Posted Date: 2024-12-19

Last Posted Date: 2025-05-06

Lead Sponsor: Centre of Postgraduate Medical Education

Target Recruit Count: 80

Registration Number: NCT06741410

Locations: 🇵🇱
Centre of Postgraduate Medical Education,Department of Anesthesia and Intensive Care, Warsaw, Poland

Ephedrine for Reducing Onset Time of Rocurinium in Elderly Patients

Phase 4

Recruiting

Conditions: Neuromuscular Blockade

Interventions: Drug: Ephedrine Hydrochloride 30 mg/ml
Drug: Saline (NaCl 0,9 %) (placebo)

First Posted Date: 2024-11-08

Last Posted Date: 2025-01-17

Lead Sponsor: Matias Vested

Target Recruit Count: 80

Registration Number: NCT06681662

Locations: 🇩🇰
Department of Anaesthesiology, Pain and Respiratory Support, Rigshospitalet Glostrup, Copenhagen, Denmark
🇩🇰
Department of Anesthesia, Centre of Head and Orthopedics, 6013 Rigshospitalet, Copenhagen, Denmark