Varenicline
- Generic Name
- Varenicline
- Brand Names
- Champix, Chantix, Tyrvaya
- Drug Type
- Small Molecule
- Chemical Formula
- C13H13N3
- CAS Number
- 249296-44-4
- Unique Ingredient Identifier
- W6HS99O8ZO
- Background
Varenicline is a prescription medication used to treat smoking addiction. This medication is the first approved nicotinic receptor partial agonist. Specifically, varenicline is a partial agonist of the alpha4/beta2 subtype of the nicotinic acetylcholine receptor. In addition it acts on alpha3/beta4 and weakly on alpha3beta2 and alpha6-containing receptors. A...
- Indication
For use as an aid in smoking cessation.
Varenicline as a nasal spray is indicated for the symptomatic treatment of dry eye disease.
- Associated Conditions
- Dry Eye Syndrome (DES)
- Associated Therapies
- Smoking, Cessation
Evaluating Smoking Cessation Interventions for PWH in South Africa
- First Posted Date
- 2022-06-09
- Last Posted Date
- 2024-08-09
- Lead Sponsor
- Johns Hopkins University
- Target Recruit Count
- 660
- Registration Number
- NCT05413122
- Locations
- 🇿🇦
Perinatal HIV Research Unit (PHRU), Soweto, Gauteng, South Africa
Varenicline for the Treatment of Cannabis and Tobacco Use Disorders in Veterans
- Conditions
- Interventions
- First Posted Date
- 2022-03-24
- Last Posted Date
- 2024-08-27
- Lead Sponsor
- VA Office of Research and Development
- Registration Number
- NCT05294263
- Locations
- 🇺🇸
Ralph H. Johnson VA Medical Center, Charleston, SC, Charleston, South Carolina, United States
Wellness Intervention for Smoking and HIV
- First Posted Date
- 2021-01-27
- Last Posted Date
- 2024-02-08
- Lead Sponsor
- University of Arizona
- Target Recruit Count
- 200
- Registration Number
- NCT04725617
- Locations
- 🇺🇸
Banner University Medical Center Phoenix, Phoenix, Arizona, United States
🇺🇸University of Arizona, Tucson, Arizona, United States
Effectiveness of an Enhanced Tobacco Intervention Protocol Compared to Standard Treatment in Helping Head and Neck and Lung Cancer Patients Starting Treatment to Reduce Cigarette Use
- Conditions
- Interventions
- First Posted Date
- 2021-01-05
- Last Posted Date
- 2024-05-13
- Lead Sponsor
- Thomas Jefferson University
- Target Recruit Count
- 40
- Registration Number
- NCT04694846
- Locations
- 🇺🇸
Sidney Kimmel Cancer Center at Thomas Jefferson Univeristy, Philadelphia, Pennsylvania, United States
🇺🇸Jefferson Health, Methodist Hospital, Philadelphia, Pennsylvania, United States
Tobacco Treatment Optimization and Preferences During Concurrent Cancer Treatment
- Conditions
- Interventions
- First Posted Date
- 2020-11-18
- Last Posted Date
- 2024-06-07
- Lead Sponsor
- Joseph Valentino, MD
- Target Recruit Count
- 126
- Registration Number
- NCT04634071
- Locations
- 🇺🇸
Kings Daughters Medical Center - Ashland, Ashland, Kentucky, United States
🇺🇸Med Center Health, Bowling Green, Kentucky, United States
🇺🇸University Of Kentucky, Markey Cancer Center, Lexington, Kentucky, United States
Nicotine Replacement Therapy, Counseling, Varenicline, and Bupropion for Smoking Cessation, the PISCES I Trial
- First Posted Date
- 2020-10-27
- Last Posted Date
- 2024-10-01
- Lead Sponsor
- M.D. Anderson Cancer Center
- Target Recruit Count
- 2010
- Registration Number
- NCT04604509
- Locations
- 🇺🇸
M D Anderson Cancer Center, Houston, Texas, United States
Varenicline For Nicotine Vaping Cessation In Non Smoker Vaper Adolescents
- First Posted Date
- 2020-10-26
- Last Posted Date
- 2024-04-04
- Lead Sponsor
- Massachusetts General Hospital
- Target Recruit Count
- 5
- Registration Number
- NCT04602494
- Locations
- 🇺🇸
Center for Addiction Medicine, Boston, Massachusetts, United States
Metabolism Informed Smoking Treatment: The MIST RCT
- Conditions
- Interventions
- First Posted Date
- 2020-10-19
- Last Posted Date
- 2024-12-05
- Lead Sponsor
- Vanderbilt-Ingram Cancer Center
- Target Recruit Count
- 608
- Registration Number
- NCT04590404
- Locations
- 🇺🇸
Vanderbilt University Medical Center ViTAL, Vanderbilt Center for Tobacco, Addiction, and Lifestyle General Internal Medicine and Public Health 2525 West End Ave, Suite 450, Nashville, Tennessee, United States
Financial Incentives for Homeless Smokers: A Community-based RCT
- Conditions
- Interventions
- First Posted Date
- 2020-06-24
- Last Posted Date
- 2024-12-05
- Lead Sponsor
- Massachusetts General Hospital
- Target Recruit Count
- 184
- Registration Number
- NCT04445662
- Locations
- 🇺🇸
Boston Health Care for the Homeless Program, Boston, Massachusetts, United States
Crossover Target Engagement Study of Cholinergic Mechanisms of Gait Dysfunction in Parkinson's Disease (Project #3 - Experiment 3 [UdallP3E3])
- First Posted Date
- 2020-05-27
- Last Posted Date
- 2021-01-27
- Lead Sponsor
- University of Michigan
- Target Recruit Count
- 34
- Registration Number
- NCT04403399
- Locations
- 🇺🇸
University of Michigan, Ann Arbor, Michigan, United States
Drug Development Updates
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