Overview
Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve various types of pain, including pain caused by musculoskeletal conditions, osteoarthritis, and rheumatoid arthritis. With a longer half-life than most other NSAIDS, it is a favorable option for those who require once-daily dosing. Meloxicam is available in oral, transdermal, and intravenous formulations. It is a preferential COX-2 inhibitor, purportedly reducing the risk of adverse gastrointestinal tract effects, however, this is a topic of controversy.
Background
Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve various types of pain, including pain caused by musculoskeletal conditions, osteoarthritis, and rheumatoid arthritis. With a longer half-life than most other NSAIDS, it is a favorable option for those who require once-daily dosing. Meloxicam is available in oral, transdermal, and intravenous formulations. It is a preferential COX-2 inhibitor, purportedly reducing the risk of adverse gastrointestinal tract effects, however, this is a topic of controversy.
Indication
Meloxicam is indicated for the symptomatic treatment of arthritis and osteoarthritis. In addition, it is indicated for the pauciarticular and polyarticular course of Juvenile Rheumatoid Arthritis (JRA) in patients aged 2 years old or above. Off-label uses include the treatment of dental or post-surgical pain. In addition to the above, meloxicam has also been studied in the treatment of neuropathic pain. Meloxicam, in combination with bupivacaine, is indicated for postsurgical analgesia in adult patients for up to 72 hours following foot and ankle, small-to-medium open abdominal, and lower extremity total joint arthroplasty surgical procedures.
Associated Conditions
- Dental Pain
- Neuropathic Pain
- Osteoarthritis (OA)
- Pain, Inflammatory
- Pauciarticular juvenile rheumatoid arthritis
- Polyarticular juvenile rheumatoid arthritis, chronic or unspecified
- Postoperative pain
- Rheumatoid Arthritis
Clinical Trials
Title | Posted | Study ID | Phase | Status | Sponsor |
|---|---|---|---|---|---|
2025/04/01 | Phase 3 | Completed | |||
2024/11/25 | Phase 4 | Not yet recruiting | |||
2024/04/23 | Phase 3 | Completed | CSPC ZhongQi Pharmaceutical Technology Co., Ltd. | ||
2024/03/12 | Phase 2 | Recruiting | |||
2023/08/03 | Phase 4 | Completed | |||
2023/07/18 | Phase 2 | Not yet recruiting | |||
2023/01/25 | Phase 2 | Recruiting | |||
2022/04/07 | Phase 4 | Terminated | Baudax Bio | ||
2022/03/22 | Phase 3 | Completed | |||
2021/10/28 | Not Applicable | Completed | Alfarabi Colleges |
FDA Drug Approvals
Approved Product | Manufacturer | NDC Code | Route | Strength | Effective Date |
|---|---|---|---|---|---|
| Exelan Pharmaceuticals Inc. | 76282-153 | ORAL | 15 mg in 1 1 | 2/17/2023 | |
| Carlsbad Technology, Inc. | 61442-126 | ORAL | 7.5 mg in 1 1 | 2/17/2023 | |
| STERLING KNIGHT PHARMACEUTICALS, LLC | 69336-102 | ORAL | 15 mg in 1 1 | 12/30/2015 | |
| Northwind Pharmaceuticals, LLC | 51655-571 | ORAL | 15 mg in 1 1 | 1/25/2023 | |
| REMEDYREPACK INC. | 70518-1299 | ORAL | 7.5 mg in 1 1 | 2/15/2024 | |
| AiPing Pharmaceutical, Inc | 11788-047 | ORAL | 15 mg in 1 1 | 10/6/2023 | |
| Belcher Pharmaceuticals,LLC | 62250-676 | ORAL | 15 mg in 1 1 | 6/30/2015 | |
| REMEDYREPACK INC. | 70518-1630 | ORAL | 15 mg in 1 1 | 6/23/2025 | |
| Advanced Rx Pharmacy of Tennessee, LLC | 80425-0043 | ORAL | 7.5 mg in 1 1 | 11/10/2022 | |
| Dispensing Solutions, Inc. | 66336-774 | ORAL | 15 mg in 1 1 | 7/3/2013 |
EMA Drug Approvals
Approved Product | Authorization Holder | Status | Issued Date |
|---|---|---|---|
| No EMA approvals found for this drug. | |||
HSA Drug Approvals
Approved Product | Manufacturer | Approval Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| Arrox Tablet 7.5mg | SIN14305P | TABLET | 7.50mg | 1/31/2013 | |
| MOBIC TABLET 7.5 mg | SIN09554P | TABLET | 7.5 mg | 11/28/1997 | |
| MELOX TABLET 7.5 mg | SIN12127P | TABLET | 7.5 mg | 11/20/2002 |
NMPA Drug Approvals
Approved Product | Company | Approval Number | Drug Type | Dosage Form | Approval Date |
|---|---|---|---|---|---|
| Meloxicam Capsules | 国药准字H20020432 | 化学药品 | 胶囊剂 | 4/26/2020 | |
| Meloxicam Capsules | 国药准字H20020243 | 化学药品 | 胶囊剂 | 8/21/2020 | |
| Meloxicam Capsules | 国药准字H20040363 | 化学药品 | 胶囊剂 | 6/17/2020 | |
| Meloxicam Capsules | 国药准字H20010303 | 化学药品 | 胶囊剂 | 4/9/2020 | |
| Meloxicam Capsules | 国药准字H20010205 | 化学药品 | 胶囊剂 | 3/27/2020 | |
| Meloxicam Capsules | 国药准字H20030487 | 化学药品 | 胶囊剂 | 3/2/2020 | |
| Meloxicam Capsules | 国药准字H20030643 | 化学药品 | 胶囊剂 | 11/21/2019 | |
| Meloxicam Capsules | 国药准字H20010002 | 化学药品 | 胶囊剂 | 3/10/2020 | |
| Meloxicam Capsules | 国药准字H20010209 | 化学药品 | 胶囊剂 | 5/15/2020 | |
| Meloxicam Capsules | 国药准字H20031203 | 化学药品 | 胶囊剂 | 9/3/2019 |
PPB Drug Approvals
Approved Product | Registration No. | Company | Licence No. | Strength | Registration Date |
|---|---|---|---|---|---|
| MELFLAM-7.5 TAB 7.5MG | N/A | N/A | N/A | 3/14/2005 | |
| NEWSICAM CAP 15MG | N/A | N/A | N/A | 2/8/2010 | |
| MEDICON CAPSULE 7.5MG | N/A | N/A | N/A | 8/7/2014 | |
| MOCAM TABLETS 7.5MG | N/A | N/A | N/A | 10/3/2019 |
TGA Drug Approvals
Approved Product | ARTG ID | Sponsor | Registration Type | Status | Registration Date |
|---|---|---|---|---|---|
| MELOXICAM SANDOZ meloxicam 7.5 mg tablet blister pack | 288943 | Medicine | A | 7/12/2017 | |
| MELOXICAM VIATRIS meloxicam 7.5 mg tablet blister pack | 389282 | Medicine | A | 10/7/2022 | |
| GENRX MELOXICAM | 181202 | Medicine | A | 10/18/2011 | |
| MELOXICAM GPPL meloxicam 7.5 mg capsule blister pack | 232578 | Medicine | A | 9/23/2015 | |
| CIP MELOXICAM 7.5 meloxicam 7.5 mg tablet blister pack | 298957 | Medicine | A | 4/4/2018 | |
| MELOXIBELL meloxicam 7.5mg tablet blister pack | 127413 | Medicine | A | 7/31/2007 | |
| MELOBIC 15 meloxicam 15 mg tablets blister pack | 188883 | Medicine | A | 8/28/2012 | |
| MOXICAM meloxicam 15 mg tablet blister pack | 126215 | Medicine | A | 5/15/2007 | |
| AGILOCAM meloxicam 15 mg capsule blister pack | 232587 | Medicine | A | 9/23/2015 | |
| MELOBIC 15 meloxicam 15 mg capsule blister pack | 232583 | Medicine | A | 9/23/2015 |