Cyclosporine

Generic Name
Cyclosporine
Brand Names
Cequa, Gengraf, Neoral, Restasis, Sandimmune, Verkazia, Vevye, Ikervis
Drug Type
Small Molecule
Chemical Formula
C62H111N11O12
CAS Number
59865-13-3
Unique Ingredient Identifier
83HN0GTJ6D
Background

Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus Beauveria nivea. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products by Novar...

Indication

Cyclosporine is approved for a variety of conditions. Firstly, it is approved for the prophylaxis of organ rejection in allogeneic kidney, liver, and heart transplants. It is also used to prevent bone marrow transplant rejection. For the above indications, cyclosporine can be used in conjunction with azathioprine and corticosteroids. Finally, cyclosporine ca...

Associated Conditions
Atopic Dermatitis, Bone Marrow Transplant Rejection, Chronic transplant rejection, Connective Tissue Disorders, Dry Eyes, Graft-versus-host Disease (GVHD), Heart Transplant Rejection, Immune Thrombocytopenia (ITP), Interstitial Cystitis, Juvenile Idiopathic Arthritis (JIA), Kidney Transplant Rejection, Liver Transplant Rejection, Lupus Nephritis, Nephrotic Syndrome, Ocular Rosacea, Rheumatoid Arthritis, Severe Ulcerative Colitis, Steroid Dependent Nephrotic Syndrome, Steroid Resistant Nephrotic Syndrome, Uveitis, Vernal Keratoconjunctivitis, Blistering disorder, Refractory Ulcerative colitis, Severe Psoriasis, Severe, active Rheumatoid arthritis, Severe, recalcitrant Plaque psoriasis, Suppressed tear production
Associated Therapies
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Donor Peripheral Stem Cell Transplant in Treating Patients With Myelodysplastic Syndrome, Acute Myeloid Leukemia, or Myeloproliferative Disorder

First Posted Date
2003-01-27
Last Posted Date
2010-09-16
Lead Sponsor
Fred Hutchinson Cancer Center
Target Recruit Count
30
Registration Number
NCT00049634
Locations
🇺🇸

Fred Hutchinson Cancer Research Center, Seattle, Washington, United States

🇺🇸

Seattle Cancer Care Alliance, Seattle, Washington, United States

Low-Dose Total-Body Irradiation and Fludarabine Phosphate Followed By Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Stage IV Kidney Cancer

First Posted Date
2003-01-27
Last Posted Date
2019-07-24
Lead Sponsor
Fred Hutchinson Cancer Center
Target Recruit Count
11
Registration Number
NCT00005851
Locations
🇺🇸

Rocky Mountain Cancer Centers-Aurora, Aurora, Colorado, United States

🇺🇸

Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium, Seattle, Washington, United States

🇺🇸

Froedtert and the Medical College of Wisconsin, Milwaukee, Wisconsin, United States

and more 3 locations

Combination Chemotherapy Followed by Donor Bone Marrow Transplant or Peripheral Stem Cell Transplant in Treating Patients With Hematologic Cancer or Genetic Disorders

First Posted Date
2003-01-27
Last Posted Date
2014-01-06
Lead Sponsor
Herbert Irving Comprehensive Cancer Center
Target Recruit Count
52
Registration Number
NCT00008307
Locations
🇺🇸

Herbert Irving Comprehensive Cancer Center at Columbia University, New York, New York, United States

Umbilical Cord Blood Transplantation in Treating Patients With High-Risk Hematologic Cancer

First Posted Date
2003-01-27
Last Posted Date
2012-03-15
Lead Sponsor
Case Comprehensive Cancer Center
Target Recruit Count
44
Registration Number
NCT00003335
Locations
🇺🇸

Case Medical Center, University Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center, Cleveland, Ohio, United States

Monoclonal Antibody Therapy Plus Chemotherapy Followed by Peripheral Stem Cell Transplantation in Treating Patients With Metastatic Prostate Cancer That Has Not Responded to Hormone Therapy

Phase 1
Conditions
First Posted Date
2003-01-27
Last Posted Date
2013-09-20
Lead Sponsor
University of California, Davis
Registration Number
NCT00009750
Locations
🇺🇸

University of California Davis Cancer Center, Sacramento, California, United States

Cyclosporine in Treating Patients With Low Blood Counts Caused By Hematologic Cancer

First Posted Date
2003-01-27
Last Posted Date
2016-07-06
Lead Sponsor
Alliance for Clinical Trials in Oncology
Target Recruit Count
30
Registration Number
NCT00031980
Locations
🇺🇸

Roswell Park Cancer Institute, Buffalo, New York, United States

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