Clonidine

Generic Name: Clonidine

Brand Names: Catapres, Catapres-TTS, Catapres-tts-1, Duraclon, Kapvay, Nexiclon XR

Drug Type: Small Molecule

Chemical Formula: C_₉H_₉Cl_₂N_₃

CAS Number: 4205-90-7

Unique Ingredient Identifier: MN3L5RMN02

Background: Clonidine is an imidazole derivate that acts as an agonist of alpha-2 adrenoceptors. This activity is useful for the treatment of hypertension, severe pain, and ADHD.

Clonidine was granted FDA approval on 3 September 1974.

Indication: Clonidine tablets and transdermal systems are indicated for the treatment of hypertension alone or in combination with other medications. A clonidine injection is indicated for use with opiates in the treatment of severe cancer pain where opiates alone are insufficient. An extended release tablet of clonidine is indicated for the treatment of ADHD either alo...

Associated Conditions: Attention Deficit Hyperactivity Disorder (ADHD), Defiant Disorder, Oppositional, Gilles de la Tourette's Syndrome, Hot Flashes, Human Growth Hormone Deficiency, Hypertension, Opioid Withdrawal (Disorder), Pheochromocytoma, Postherpetic Neuralgia, Sialorrhea caused by clozapine, Diabetic diarrhea, Methadone withdrawal, Severe Cancer pain

Associated Therapies: Smoking, Cessation

Clinical Trials

Combination of Dronabinol and Clonidine for Cannabis Dependence in Patients With Schizophrenia

Phase 2

Terminated

Conditions: Cannabis Dependence
Marijuana Dependence

Interventions: Drug: Placebo
Drug: Dronabinol
Drug: Clonidine

First Posted Date: 2012-05-15

Last Posted Date: 2018-08-29

Lead Sponsor: Mclean Hospital

Target Recruit Count: 12

Registration Number: NCT01598896

Locations: 🇺🇸
McLean Hospital, Belmont, Massachusetts, United States

Reduction of Pulmonary Artery Pressure in Patients Subjected to Cardiac Surgery

Phase 2

Completed

Conditions: Anesthesia

Interventions: Drug: Clonidine
Drug: Placebo

First Posted Date: 2012-05-14

Last Posted Date: 2012-05-14

Lead Sponsor: Federal University of São Paulo

Target Recruit Count: 29

Registration Number: NCT01597427

Locations: 🇧🇷
Luiz Fernando dos Reis Falcao, Sao Paulo, SP, Brazil

Transdermal Clonidine in the Treatment of Severe Hyperemesis Gravidarum

Phase 3

Completed

Conditions: Hyperemesis Gravidarum

Interventions: Drug: Clonidine

First Posted Date: 2012-03-20

Last Posted Date: 2014-04-30

Lead Sponsor: A.O.U. Città della Salute e della Scienza

Target Recruit Count: 13

Registration Number: NCT01559012

Locations: 🇮🇹
Ospedale Sant'Anna. Dipartimento di Ostetricia e Neonatologia. Servizio di Medicina Interna, Torino, Italy

Solifenacin Compared to Clonidine for Reducing Hot Flashes Among Breast Cancer Patients

Phase 2

Active, not recruiting

Conditions: Breast Cancer
Hot Flashes

Interventions: Drug: solifenacin
Drug: Clonidine

First Posted Date: 2012-02-09

Last Posted Date: 2024-05-02

Lead Sponsor: University of Arkansas

Target Recruit Count: 6

Registration Number: NCT01530373

Locations: 🇺🇸
Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States

Pilot Study for the NorCAPITAL Trial

Not Applicable

Completed

Conditions: Chronic Fatigue Syndrome

Interventions: Drug: Clonidine

First Posted Date: 2012-01-11

Last Posted Date: 2012-01-13

Lead Sponsor: Oslo University Hospital

Target Recruit Count: 5

Registration Number: NCT01507701

Locations: 🇳🇴
Oslo University Hospital Rikshospitalet, Dept. of Pediatrics, Oslo, Norway

Comparison of Postoperative Analgesic Effect of Intrathecal Clonidine and Fentanyl Added to Bupivacaine in Patients Undergoing Cesarean Section

Phase 1

Completed

Conditions: Post Operative Pain

Interventions: Drug: Fentanyl
Drug: distilled water
Drug: Clonidine

First Posted Date: 2011-08-30

Last Posted Date: 2012-05-17

Lead Sponsor: Qazvin University Of Medical Sciences

Target Recruit Count: 90

Registration Number: NCT01425658

Locations: 🇮🇷
Qazvin university of medical science, Qazvin, Iran, Islamic Republic of

Effect of Intrathecal Clonidine in Hypertensive Subjects With Poorly Controlled Blood Pressure

Phase 2

Completed

Conditions: Hypertension

Interventions: Drug: clonidine

First Posted Date: 2011-02-16

Last Posted Date: 2016-10-19

Lead Sponsor: The Center for Clinical Research, Winston-Salem, NC

Target Recruit Count: 10

Registration Number: NCT01297335

Clonidine in Femoral Nerve Block Surgery in Children

Phase 2

Withdrawn

Conditions: Other Reconstructive Surgery

Interventions: Drug: Clonidine
Drug: Ropivacaine

First Posted Date: 2011-02-10

Last Posted Date: 2015-05-08

Lead Sponsor: Nationwide Children's Hospital

Registration Number: NCT01293149

Locations: 🇺🇸
Nationwide Children's Hospital, Columbus, Ohio, United States

Comparison of Different Doses of Clonidine to Fentanyl as an Adjuvant to Bupivacaine 0.5% for Spinal Anesthesia

Not Applicable

Withdrawn

Conditions: Undergoing Lower Segment Caesarian Section
Full Term Pregnant Patients

Interventions: Drug: Fentanyl
Drug: clonidine

First Posted Date: 2010-09-20

Last Posted Date: 2017-09-21

Lead Sponsor: Pravara Institute of Medical Sciences University

Registration Number: NCT01205204

Medications Development for Drug Abuse Disorders

Phase 1

Completed

Conditions: Opioid Related Disorders
Opioid Dependence
Opioid Addiction

Interventions: Drug: Buprenorphine/naloxone
Drug: Tramadol ER
Drug: Clonidine

First Posted Date: 2010-08-25

Last Posted Date: 2017-07-06

Lead Sponsor: Johns Hopkins University

Target Recruit Count: 106

Registration Number: NCT01188421

Locations: 🇺🇸
Johns Hopkins University (BPRU) Bayview Campus, Baltimore, Maryland, United States

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