Nesiritide
- Generic Name
- Nesiritide
- Drug Type
- Biotech
- CAS Number
- 124584-08-3
- Unique Ingredient Identifier
- P7WI8UL647
- Background
Nesiritide is a medication used to treat acutely decompensated congestive heart failure with dyspnea at rest or with minimal exertion (such as talk, eating or bathing). Nesiritide is a 32 amino acid recombinant human B-type natriuretic peptide.
- Indication
适用于急性代偿性心力衰竭、慢性失代偿性心力衰竭、心肌梗死、心脏导管手术等。由于静脉使用起效快，更适用于急性心力衰竭。
- Associated Conditions
- Acute Decompensated Heart Failure (ADHF)
Cytokinetics Initiates Phase 2 Trial of CK-586 for Heart Failure with Preserved Ejection Fraction
• Cytokinetics has commenced enrollment for the AMBER-HFpEF Phase 2 trial to assess CK-586 in patients with symptomatic heart failure with preserved ejection fraction (HFpEF).
• The AMBER-HFpEF trial is a randomized, placebo-controlled, double-blind, multi-center study evaluating the safety and tolerability of CK-586.
• The trial will enroll approximately 60 patients, evaluating the impact of CK-586 on LVEF, NT-proBNP levels, patient function, and cardiac function over 12 weeks.
• CK-586 is a novel cardiac myosin inhibitor designed to reduce hypercontractility in HFpEF patients, potentially addressing a significant unmet need.
MediBeacon's TGFR System Receives FDA Approval for Kidney Function Assessment
• The FDA has approved MediBeacon's Transdermal GFR (TGFR) system for assessing kidney function in adults with normal or impaired renal function.
• The TGFR system includes a sensor, monitor, and Lumitrace injection, offering a non-invasive method without blood draws or urine analysis.
• Clinical trials demonstrated the TGFR system met its primary efficacy endpoint, achieving a P30 value of 94% across diverse patient demographics.
• The TGFR system offers a point-of-care solution, eliminating the need for complex laboratory analysis and providing rapid results.
Drug Development Updates
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