Melatonin

Generic Name: Melatonin

Brand Names: Circadin, Slenyto, Melatonin Neurim

Drug Type: Small Molecule

Chemical Formula: C_₁₃H_₁₆N_₂O_₂

CAS Number: 73-31-4

Unique Ingredient Identifier: JL5DK93RCL

Background: Melatonin is a biogenic amine that is found in animals, plants and microbes. Aaron B. Lerner of Yale University is credited for naming the hormone and for defining its chemical structure in 1958. In mammals, melatonin is produced by the pineal gland. The pineal gland is small endocrine gland, about the size of a rice grain and shaped like a pine cone (hence ...

Indication: Used orally for jet lag, insomnia, shift-work disorder, circadian rhythm disorders in the blind (evidence for efficacy), and benzodiazepine and nicotine withdrawal. Evidence indicates that melatonin is likely effective for treating circadian rhythm sleep disorders in blind children and adults. It has received FDA orphan drug status as an oral medication for ...

Associated Conditions: Insomnia

Associated Therapies: -

Clinical Trials

Melatonin Intervention For Neurocognitive Deficits in the St. Jude Lifetime Cohort

Phase 3

Completed

Conditions: Cancer Malignancies

Interventions: Drug: melatonin
Drug: placebo

First Posted Date: 2012-10-04

Last Posted Date: 2018-06-28

Lead Sponsor: St. Jude Children's Research Hospital

Target Recruit Count: 911

Registration Number: NCT01700959

Locations: 🇺🇸
St. Jude Children's Research Hospital, Memphis, Tennessee, United States

Melatonin to Prevent Brain Injury in Unborn Growth Restricted Babies

Phase 4

Completed

Conditions: Fetal Growth Retardation

Interventions: Drug: Melatonin

First Posted Date: 2012-09-27

Last Posted Date: 2014-11-18

Lead Sponsor: Monash University

Target Recruit Count: 16

Registration Number: NCT01695070

Locations: 🇦🇺
Southern Health: Monash Medical Centre and Jessie McPherson Private Hospital, Clayton, Victoria, Australia

Treatment of Osteopenia With Melatonin

Not Applicable

Completed

Conditions: Osteoporosis

Interventions: Drug: Melatonin

First Posted Date: 2012-09-21

Last Posted Date: 2016-05-06

Lead Sponsor: University of Aarhus

Target Recruit Count: 81

Registration Number: NCT01690000

Locations: 🇩🇰
Osteoporoseklinikken, dept of Endocrinology and Internal Medicine (MEA), Aarhus C, Denmark

Randomized Controlled Trial to Assess Efficacy of Melatonin for Children During Burn Rehabilitation

Phase 2

Terminated

Conditions: Burns

Interventions: Drug: Melatonin
Other: placebo

First Posted Date: 2012-05-15

Last Posted Date: 2016-06-28

Lead Sponsor: Shriners Hospitals for Children

Target Recruit Count: 10

Registration Number: NCT01598259

Locations: 🇺🇸
Shriners Hospital for Children, Cincinnati, Ohio, United States

Melatonin for Prevention of Metabolic Side Effects of Olanzapine

Phase 2

Completed

Conditions: Schizophrenia

Interventions: Drug: Placebo
Drug: Melatonin

First Posted Date: 2012-05-08

Last Posted Date: 2013-04-09

Lead Sponsor: Guilan University of Medical Sciences

Target Recruit Count: 36

Registration Number: NCT01593774

Locations: 🇮🇷
Shafa Psychiatric Hospital, Rasht, Guilan, Iran, Islamic Republic of

The Effect of Melatonin on Nocturnal Enuresis

Phase 2

Conditions: Nocturnal Enuresis

Interventions: Drug: Melatonin
Drug: Lactose

First Posted Date: 2012-04-11

Last Posted Date: 2012-11-02

Lead Sponsor: University of Aarhus

Target Recruit Count: 40

Registration Number: NCT01575678

Locations: 🇩🇰
Center of Child Incontinence, Pediatric department, Aarhus Universityhospital, Aarhus, Region Midtjylland, Denmark

Melatonin Associated to Acid Inhibition for Chemoprevention in Barret Esophagus: a Pilot Study

Phase 3

Completed

Conditions: Barrett's Esophagus

Interventions: Drug: Melatonin
Drug: Omeprazole

First Posted Date: 2012-03-29

Last Posted Date: 2019-09-13

Lead Sponsor: Aragon Institute of Health Sciences

Target Recruit Count: 80

Registration Number: NCT01566474

Locations: 🇪🇸
Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain

Melatonin as Adjuvant Therapy in Breast Cancer Patients

Phase 2

Conditions: Stage II and III Breast Cancer

Interventions: Drug: match placebo
Drug: Melatonin

First Posted Date: 2012-03-19

Last Posted Date: 2015-01-08

Lead Sponsor: Khon Kaen University

Target Recruit Count: 166

Registration Number: NCT01557478

Locations: 🇹🇭
Maharat Nakorn Ratchasima Hospital, Nakorn Ratchasima, Thailand
🇹🇭
Srinagarind Hospital, Khon Kaen, Thailand

Study of Melatonin on Sleep, Pain, and Confusion After Joint Replacement Surgery

Not Applicable

Completed

Conditions: Delirium
Confusion
Sleep
Postoperative Pain

Interventions: Drug: Melatonin
Drug: Placebo

First Posted Date: 2012-01-06

Last Posted Date: 2022-05-11

Lead Sponsor: Hospital for Special Surgery, New York

Target Recruit Count: 50

Registration Number: NCT01505465

Locations: 🇺🇸
Hospital for Special Surgery, New York, New York, United States

Melatonin Versus Placebo for Benzodiazepine Discontinuation in Patients With Schizophrenia

Phase 4

Completed

Conditions: Schizophrenia
Schizoaffective Disorder
Bipolar Affective Disorder

Interventions: Drug: Placebo
Drug: Melatonin

First Posted Date: 2011-09-09

Last Posted Date: 2014-06-06

Lead Sponsor: Lone Baandrup

Target Recruit Count: 86

Registration Number: NCT01431092

Locations: 🇩🇰
Center for Neuropsychiatric Schizophrenia Research (CNSR)/Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS), University of Copenhagen, Mental Health Centre Glostrup, Mental Health Services - Capital Region of Denmark, Glostrup, Denmark

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