Melatonin

Generic Name
Melatonin
Brand Names
Circadin, Slenyto, Melatonin Neurim
Drug Type
Small Molecule
Chemical Formula
C13H16N2O2
CAS Number
73-31-4
Unique Ingredient Identifier
JL5DK93RCL
Background

Melatonin is a biogenic amine that is found in animals, plants and microbes. Aaron B. Lerner of Yale University is credited for naming the hormone and for defining its chemical structure in 1958. In mammals, melatonin is produced by the pineal gland. The pineal gland is small endocrine gland, about the size of a rice grain and shaped like a pine cone (hence ...

Indication

Used orally for jet lag, insomnia, shift-work disorder, circadian rhythm disorders in the blind (evidence for efficacy), and benzodiazepine and nicotine withdrawal. Evidence indicates that melatonin is likely effective for treating circadian rhythm sleep disorders in blind children and adults. It has received FDA orphan drug status as an oral medication for ...

Associated Conditions
Insomnia
Associated Therapies
-
Clinical Trials
Related News

Sleep Management And Recovery After Traumatic Brain Injury in Kids: Pilot Intervention of Melatonin

First Posted Date
2021-06-18
Last Posted Date
2023-11-18
Lead Sponsor
Oregon Health and Science University
Target Recruit Count
30
Registration Number
NCT04932096
Locations
🇺🇸

Oregon Health & Science University, Portland, Oregon, United States

Emergence Agitation After Nasal Surgery: a Randomized Controlled Comparison Between Melatonin and Mirtazapine

Phase 4
Completed
Conditions
Agitation
Interventions
Drug: Melatonin
Drug: Placebo
Drug: Mirtazapine
First Posted Date
2021-06-01
Last Posted Date
2022-04-15
Lead Sponsor
Ain Shams University
Target Recruit Count
165
Registration Number
NCT04908605
Locations
🇪🇬

Ain-Shams University Hospitals, Cairo, Egypt

Dose-Ranging Study to Assess the Safety and Efficacy of Melatonin in Outpatients Infected With COVID-19

Phase 2
Withdrawn
Conditions
COVID-19
Interventions
Drug: Placebo
Drug: Melatonin
First Posted Date
2021-03-05
Last Posted Date
2022-07-22
Lead Sponsor
State University of New York at Buffalo
Registration Number
NCT04784754
Locations
🇺🇸

University at Buffalo, Buffalo, New York, United States

Antioxidants as Adjuvant Therapy to Standard Therapy in Patients With COVID-19

First Posted Date
2020-09-30
Last Posted Date
2021-05-21
Lead Sponsor
Unidad Temporal COVID-19 en Centro Citibanamex
Target Recruit Count
110
Registration Number
NCT04570254
Locations
🇲🇽

Unidad Temporal COVID-19 en Centro Citibanamex, Mexico City, Mexico

Sleep, Diabetic Retinopathy and Melatonin

First Posted Date
2020-09-14
Last Posted Date
2023-10-31
Lead Sponsor
University of Illinois at Chicago
Target Recruit Count
36
Registration Number
NCT04547439
Locations
🇺🇸

University of Illinois at Chicago, Chicago, Illinois, United States

Selective Estrogen Modulation and Melatonin in Early COVID-19

Phase 2
Withdrawn
Conditions
Covid19
Interventions
Other: Placebo
Drug: Toremifene
Drug: Melatonin
First Posted Date
2020-08-28
Last Posted Date
2021-05-10
Lead Sponsor
Reena Mehra, MD
Registration Number
NCT04531748

Safety and Efficacy of Melatonin in Outpatients Infected With COVID-19

First Posted Date
2020-07-16
Last Posted Date
2024-02-07
Lead Sponsor
State University of New York at Buffalo
Target Recruit Count
8
Registration Number
NCT04474483
Locations
🇺🇸

University at Buffalo, Buffalo, New York, United States

Evaluation of Therapeutic Effects of Melatonin by Inhibition of NLRP3 Inflammasome in COVID19 Patients

Not Applicable
Conditions
COVID-19
Interventions
Drug: Melatonin
Drug: The usual treatment
First Posted Date
2020-06-01
Last Posted Date
2020-06-01
Lead Sponsor
Mohammad Sadegh Bagheri Baghdasht
Target Recruit Count
55
Registration Number
NCT04409522
Locations
🇮🇷

Mohammad Sadegh Bagheri Baghdasht, Tehran, Iran, Islamic Republic of

Melatonin Supplementation in Postmenopausal Women With H. Pylori-associated Dyspepsia

First Posted Date
2020-04-17
Last Posted Date
2020-04-17
Lead Sponsor
Medical University of Lodz
Target Recruit Count
152
Registration Number
NCT04352062
Locations
🇵🇱

Department of Clinical Nutrition and Gastroenterological Diagnostics Medical University of Lodz, Łódź, Poland

Melatonin on Clock Genes in Parkinson's Disease

Phase 2
Withdrawn
Conditions
Parkinson Disease
Interventions
Drug: Melatonin
Drug: Placebos
First Posted Date
2020-02-27
Last Posted Date
2020-08-04
Lead Sponsor
Instituto Mexicano del Seguro Social
Registration Number
NCT04287543
Locations
🇲🇽

Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, Mexico

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