Toremifene

Background: Toremifene is a selective estrogen receptor modulator (SERM) and a nonsteroidal antiestrogen used to treat estrogen receptor positive breast cancer. Like tamoxifen, toremifene is part of the first-generation triphenylethylene derivative chemical class of SERMs.
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Indication: For the treatment of metastatic breast cancer in postmenopausal women with estrogen receptor-positive or receptor-unknown tumors. Toremifene is currently under investigation as a preventative agent for prostate cancer in men with high-grade prostatic intraepithelial neoplasia and no evidence of prostate cancer.

Toremifene Followed by Radical Prostatectomy in Treating Patients With Stage I or Stage II Prostate Cancer

Phase 2

Completed

Interventions: Procedure: conventional surgery
Drug: toremifene
Procedure: neoadjuvant therapy

Locations: 🇺🇸
Hillman Cancer Center at University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, United States

Phase 3

Completed

Interventions: Drug: atamestane
Drug: letrozole
Drug: aromatase inhibition
Drug: toremifene
Procedure: hormone therapy
Procedure: endocrine therapy
Procedure: antiestrogen therapy

Locations: 🇺🇦
Kharkov Medical Academy of Postgraduate Education, Oncology and Pediatric Oncology Department. Clinical Facility: Kharkov Regional Clinical Oncology Dispensary, Chemotherapy Department, Kharkov, Ukraine
🇺🇦
Odessa State Medical University, Oncology Department. Clinical Facility: Odessa Regional Oncology Center, Chemotherapy Department, Odessa, Ukraine
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V. Novgorod Regional Oncology Center, Department of Chemotherapy, V. Novgorod, Russian Federation

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