Toremifene

Generic Name
Toremifene
Brand Names
Fareston
Drug Type
Small Molecule
Chemical Formula
C26H28ClNO
CAS Number
89778-26-7
Unique Ingredient Identifier
7NFE54O27T
Background

Toremifene is a selective estrogen receptor modulator (SERM) and a nonsteroidal antiestrogen used to treat estrogen receptor positive breast cancer. Like tamoxifen, toremifene is part of the first-generation triphenylethylene derivative chemical class of SERMs.
...

Indication

For the treatment of metastatic breast cancer in postmenopausal women with estrogen receptor-positive or receptor-unknown tumors. Toremifene is currently under investigation as a preventative agent for prostate cancer in men with high-grade prostatic intraepithelial neoplasia and no evidence of prostate cancer.

Associated Conditions
Metastatic Breast Cancer
Associated Therapies
-

Efficacy and Safety of Fluzoparib Combined With Adjuvant Endocrine Therapy for HR+/HER2- SNF3-subtype Early Breast Cancer (BCTOP-L-A01)

First Posted Date
2023-06-06
Last Posted Date
2024-02-08
Lead Sponsor
Fudan University
Target Recruit Count
766
Registration Number
NCT05891093
Locations
🇨🇳

Sun Yat-sen University Cancer Center, Guangdong, Guangzhou, China

🇨🇳

Shanghai Sixth People's Hospital Affiliated to Shanghai Jiaotong University, Shanghai, Shanghai, China

🇨🇳

Fujian Medical University Union Hospital, Fuzhou, Fujian, China

and more 12 locations

Effect of Endocrine Therapy Duration on Clinical Outcome of Patients With HR+ Intraductal Carcinoma of the Breast

First Posted Date
2020-12-14
Last Posted Date
2020-12-14
Lead Sponsor
First Hospital of China Medical University
Target Recruit Count
1354
Registration Number
NCT04666805
Locations
🇨🇳

The First Hospital of China Medical University, Shenyang, Liaoning, China

Selective Estrogen Modulation and Melatonin in Early COVID-19

Phase 2
Withdrawn
Conditions
Interventions
First Posted Date
2020-08-28
Last Posted Date
2021-05-10
Lead Sponsor
Reena Mehra, MD
Registration Number
NCT04531748

Efficacy of Tamoxifen Versus Toremifene in CYP2D6 IM/PM of Premenopausal Patients With ER-positive Early Breast Cancer

Phase 3
Recruiting
Conditions
Interventions
First Posted Date
2017-11-22
Last Posted Date
2017-11-22
Lead Sponsor
Chinese Anti-Cancer Association
Target Recruit Count
844
Registration Number
NCT03351062
Locations
🇨🇳

Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing, Beijing, China

🇨🇳

Hebei Tumor Hospital, Shijiazhuang, Hebei, China

🇨🇳

Hunan Cancer Hospital, Changsha, Hunan, China

and more 18 locations

Neoadjuvant Toremifene With Melatonin or Metformin in Locally Advanced Breast Cancer

First Posted Date
2015-07-23
Last Posted Date
2019-09-04
Lead Sponsor
N.N. Petrov National Medical Research Center of Oncology
Target Recruit Count
96
Registration Number
NCT02506790
Locations
🇷🇺

N.N. Petrov Research Institute of Oncology Clinical Diagnostic Department, Saint - Petersburg, Russian Federation

Toremifene in Desmoid Tumor: Prospective Clinical Trial and Identification of Potential Molecular Targets

Phase 2
Conditions
Interventions
First Posted Date
2015-02-02
Last Posted Date
2015-02-02
Lead Sponsor
Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Target Recruit Count
25
Registration Number
NCT02353429
Locations
🇮🇹

Fondazione IRCCS Istituto Tumori Milano, Milan, Italy

Safety of Toremifene and Tamoxifen Therapy in Premenopausal Patients With Operable Breast Cancer

Phase 4
Completed
Conditions
Interventions
First Posted Date
2015-01-26
Last Posted Date
2019-09-24
Lead Sponsor
Shanghai Jiao Tong University School of Medicine
Target Recruit Count
104
Registration Number
NCT02344940
Locations
🇨🇳

Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, Shanghai, China

Estradiol-Receptor Blockade in Older Men and Women

First Posted Date
2014-10-22
Last Posted Date
2016-09-14
Lead Sponsor
Mayo Clinic
Target Recruit Count
40
Registration Number
NCT02271282
Locations
🇺🇸

Mayo Clinic in Rochester, Rochester, Minnesota, United States

Adjuvant Toremifene With or Without Goserrelin in Premenopausal Women With Stage I-IIIA, Hormonal Receptor Positive Breast Cancer Accompanied With or Without Chemotherapy Induced Amenorrhoea

First Posted Date
2014-05-07
Last Posted Date
2014-06-04
Lead Sponsor
Peking Union Medical College Hospital
Target Recruit Count
300
Registration Number
NCT02132390
Locations
🇨🇳

Peking Union Medical College Hospital, Beijing, Beijing, China

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