Sitagliptin
- Generic Name
- Sitagliptin
- Brand Names
- Janumet, Januvia, Ristaben, Steglujan, Tesavel, Velmetia, Xelevia, Sitagliptin SUN, Sitagliptin Accord
- Drug Type
- Small Molecule
- Chemical Formula
- C16H15F6N5O
- CAS Number
- 486460-32-6
- Unique Ingredient Identifier
- QFP0P1DV7Z
- Background
Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used in conjunction with diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus. The effect of this medication leads to glucose dependent increases in insulin and decreases in glucagon to improve control of blood sugar. Sitagliptin was granted FDA approval on Oct...
- Indication
Sitagliptin is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. It is not used to treat type 1 diabetes or patients with a history of pancreatitis.
It is also used in combination with metformin or ertugliflozin.
- Associated Conditions
- Type 2 Diabetes Mellitus
- Associated Therapies
- -
Effects of DPP-4 Inhibition on Calcium and Bone Metabolism in Type 2 Diabetes Mellitus
- First Posted Date
- 2015-05-14
- Last Posted Date
- 2017-06-01
- Lead Sponsor
- University of Missouri-Columbia
- Registration Number
- NCT02444364
- Locations
- 🇺🇸
University of Missouri-Columbia: Diabetes Center, Columbia, Missouri, United States
Dynamic Responsiveness of Insulin Secretory Parameters To Sitagliptin and Glimeperide Administration in Type 2 DM
- Conditions
- Interventions
- First Posted Date
- 2015-05-14
- Last Posted Date
- 2015-05-14
- Lead Sponsor
- Foundation for the National Institutes of Health
- Target Recruit Count
- 100
- Registration Number
- NCT02443922
Sitagliptin in Non-Diabetic Patients Undergoing Cardiac Surgery
- First Posted Date
- 2015-05-13
- Last Posted Date
- 2018-02-06
- Lead Sponsor
- Emory University
- Target Recruit Count
- 68
- Registration Number
- NCT02443402
- Locations
- 🇺🇸
Emory Saint Joseph's Hospital, Atlanta, Georgia, United States
🇺🇸Grady Health System, Atlanta, Georgia, United States
🇺🇸Emory University Hospital - Midtown, Atlanta, Georgia, United States
Sitagliptin and Endothelial Dysfunction
- First Posted Date
- 2015-04-02
- Last Posted Date
- 2015-04-02
- Lead Sponsor
- Kyunghee University Medical Center
- Target Recruit Count
- 10
- Registration Number
- NCT02406950
- Locations
- 🇰🇷
Kyung Hee University Hospital, Seoul, Korea, Republic of
Study on Exploring the Effect of DPP-4 Inhibitors on β-cell Function by Using the Two-step Hyperglycemic Clamp
- First Posted Date
- 2015-03-12
- Last Posted Date
- 2015-03-12
- Lead Sponsor
- Shanghai Jiao Tong University School of Medicine
- Target Recruit Count
- 12
- Registration Number
- NCT02386943
- Locations
- 🇨🇳
Shanghai Jiao Tong University School of Medicine, Shanghai, China
Risk of Nocturnal Hypoglycemia and Arrhythmias With Sitagliptin Versus Glimepiride in Patients With Type 2 Diabetes
- Conditions
- Interventions
- First Posted Date
- 2015-02-27
- Last Posted Date
- 2019-02-27
- Lead Sponsor
- GWT-TUD GmbH
- Target Recruit Count
- 4
- Registration Number
- NCT02373865
- Locations
- 🇩🇪
GWT-TUD GmbH / Studienzentrum Hanefeld, Dresden, Germany
Triple Combination Therapy in Type 2 Diabetic Patients Who Had Inadequate Glycemic Control With Combination Therapy
- Conditions
- Interventions
- First Posted Date
- 2015-01-14
- Last Posted Date
- 2022-01-04
- Lead Sponsor
- Seoul National University Bundang Hospital
- Target Recruit Count
- 78
- Registration Number
- NCT02338921
- Locations
- 🇰🇷
Soo Lim, Seongnam, Gyeonggi, Korea, Republic of
Influence of Gut Hormones on Food Intake After Roux-en-Y Gastric Bypass Surgery
- Conditions
- Interventions
- First Posted Date
- 2015-01-13
- Last Posted Date
- 2016-06-21
- Lead Sponsor
- Hvidovre University Hospital
- Target Recruit Count
- 12
- Registration Number
- NCT02336659
- Locations
- 🇩🇰
Hvidovre University Hospital, Hvidovre, Denmark
Randomized Evaluation of Anagliptin Versus Sitagliptin On Low-density lipoproteiN Cholesterol in Diabetes Trial
- Conditions
- Interventions
- First Posted Date
- 2015-01-05
- Last Posted Date
- 2019-08-28
- Lead Sponsor
- Institute for Clinical Effectiveness, Japan
- Target Recruit Count
- 353
- Registration Number
- NCT02330406
- Locations
- 🇯🇵
Department of Cardiovascular Medicine, Tomishiro Central Hospital, Tomishiro, Okinawa, Japan
Effects of Sitagliptin on Gastric Emptying, Glycaemia and Blood Pressure in Type 2 Diabetes
- First Posted Date
- 2014-12-24
- Last Posted Date
- 2017-07-07
- Lead Sponsor
- Royal Adelaide Hospital
- Target Recruit Count
- 14
- Registration Number
- NCT02324010
- Locations
- 🇦🇺
University of Adelaide, Discipline of Medicine, Royal Adelaide Hospital, Adelaide, South Australia, Australia
Drug Development Updates
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