Ramosetron

Generic Name
Ramosetron
Brand Names
-
Drug Type
Small Molecule
Chemical Formula
C17H17N3O
CAS Number
132036-88-5
Unique Ingredient Identifier
7ZRO0SC54Y
Background

Ramosetron is a serotonin 5-HT3 receptor antagonist commonly employed to treat nausea and vomiting, in addition to certain diarrheal conditions. It is believed to have higher potency and longer antiemetic action than other 1st generation 5-HT3 antagonists such as ondansetron. Currently, ramosetron is only approved for use Japan and in certain Southeast Asian...

Indication

For the treatment of nausea and vomiting and diarrhea-predominant irritable bowel syndrome in males.

Associated Conditions
Gastrointestinal Symptoms caused by cancer treatment
Associated Therapies
-
Clinical Trials
Related News

The Safety and Efficacy of 5-HT3 Receptor Antagonist (Ramosetron) for the Treatment of Fecal Incontinence

Phase 2
Not yet recruiting
Conditions
Fecal Incontinence
Interventions
Drug: Psyllium
Drug: Ramosetron
First Posted Date
2023-12-12
Last Posted Date
2023-12-12
Lead Sponsor
Seoul National University Hospital
Target Recruit Count
148
Registration Number
NCT06166615

5-HT3 Receptor Antagonist (Ramosetron) vs Loperamide for the Treatment of Low Anterior Resection Syndrome(RALARS)

Not Applicable
Recruiting
Conditions
LARS - Low Anterior Resection Syndrome
Interventions
Drug: Ramosetron
First Posted Date
2022-10-13
Last Posted Date
2023-04-25
Lead Sponsor
Seoul National University Hospital
Target Recruit Count
212
Registration Number
NCT05577845
Locations
🇰🇷

Seoul National University Hospital, Seoul, Jongro-gu, Korea, Republic of

Ramosetron OD Tablet and Postdischarge Nausea and Vomiting

Phase 4
Conditions
Day Surgery
Interventions
Drug: Ramosetron
First Posted Date
2020-03-05
Last Posted Date
2021-12-22
Lead Sponsor
Seoul National University Hospital
Target Recruit Count
138
Registration Number
NCT04297293
Locations
🇰🇷

Seoul National University Bundang Hospital, Seongnam-si, Korea, Republic of

Effect of Ramosetron on Post-discharge Nausea and Vomiting

Not Applicable
Conditions
Hysteroscopy
Interventions
Drug: Normal saline
Drug: Ramosetron
First Posted Date
2018-01-24
Last Posted Date
2018-04-20
Lead Sponsor
Seoul National University Bundang Hospital
Target Recruit Count
100
Registration Number
NCT03409835
Locations
🇰🇷

Seoul National Univ. Bundang Hospital, Seongnam, Gyeonggi, Korea, Republic of

Ramosetron Pre-treatment for PONV and QT Prolongation

Phase 4
Completed
Conditions
PONV
Prolonged QTc Interval
Interventions
Drug: Ramosetron
First Posted Date
2017-09-11
Last Posted Date
2018-03-09
Lead Sponsor
Konkuk University Medical Center
Target Recruit Count
64
Registration Number
NCT03278522
Locations
🇰🇷

Lee Sung Ho, Seoul, Korea, Republic of

Effect of Ramosetron on Heart Rate-corrected QT Interval During Robot-assisted Laparoscopic Prostatectomy With Steep Trendelenburg Position

Not Applicable
Completed
Conditions
Prostate Cancer
Interventions
Drug: Ramosetron
Drug: Normal saline
First Posted Date
2017-07-27
Last Posted Date
2020-08-25
Lead Sponsor
Yonsei University
Target Recruit Count
54
Registration Number
NCT03232125
Locations
🇰🇷

Professor, Department of Anesthesiology and Pain Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea, Republic of

Therapeutic Efficacy of Ramosetron for Treatment of Established PONV After Laparoscopic Surgery

Not Applicable
Completed
Conditions
Abdominal Mass
Interventions
Drug: Ondansetron
Drug: Ramosetron
First Posted Date
2017-01-11
Last Posted Date
2019-02-12
Lead Sponsor
Yonsei University
Target Recruit Count
80
Registration Number
NCT03017222

Clinical Trial Assessing 5-HT3 Receptor Antagonist (Ramosetron) for the Treatment of Anterior Resection Syndrome

Early Phase 1
Conditions
Anterior Resection Syndrome
Interventions
Drug: Ramosetron
First Posted Date
2016-08-17
Last Posted Date
2016-08-17
Lead Sponsor
Seoul National University Hospital
Target Recruit Count
100
Registration Number
NCT02869984

Effect of Ramosetron on Bowel Motility After Gynecological Surgery

First Posted Date
2016-07-29
Last Posted Date
2017-01-12
Lead Sponsor
Kyunghee University Medical Center
Target Recruit Count
88
Registration Number
NCT02849483
Locations
🇰🇷

Kyung Hee University Hospital, Seoul, Korea, Republic of

Effect of Ramosetron in Prevention of Intrathecal Morphine Induced Nausea and Vomiting

First Posted Date
2016-07-13
Last Posted Date
2016-07-13
Lead Sponsor
Thammasat University
Target Recruit Count
99
Registration Number
NCT02830906
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