Prednisone

Generic Name
Prednisone
Brand Names
Deltasone, Rayos, Winpred
Drug Type
Small Molecule
Chemical Formula
C21H26O5
CAS Number
53-03-2
Unique Ingredient Identifier
VB0R961HZT
Background

A synthetic anti-inflammatory glucocorticoid derived from cortisone. It is biologically inert and converted to prednisolone in the liver.

Prednisone was granted FDA approval on 21 February 1955.

Indication

Prednisone is indicated as an anti-inflammatory or immunosuppressive drug for allergic, dermatologic, gastrointestinal, hematologic, ophthalmologic, nervous system, renal, respiratory, rheumatologic, infectious, endocrine, or neoplastic conditions as well as in organ transplant.

Associated Conditions
Acne Vulgaris, Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Acute Gouty Arthritis, Acute Leukemia, Aggressive Lymphoma, Allergic Bronchopulmonary Aspergillosis, Allergic Conjunctivitis (AC), Allergic Rhinitis (AR), Allergic corneal marginal ulcers, Alveolitis, Extrinsic Allergic, Ankylosing Spondylitis (AS), Aspiration Pneumonitis, Asthma, Atopic Dermatitis, Autoimmune Hepatitis, Bell's Palsy, Berylliosis, Bullous dermatitis herpetiformis, Chorioretinitis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Contact Dermatitis, Disseminated tuberculosis, Drug hypersensitivity reaction, Edema of the cerebrum, Epicondylitis, Erythroblastopenia, Giant Cell Arteritis (GCA), Hypercalcemia of Malignancy, Idiopathic Pulmonary Fibrosis (IPF), Immune Thrombocytopenia (ITP), Iridocyclitis, Iritis, Keratitis, Leukemias, Loeffler's syndrome, Lymphoma, Meningitis caused by Mycobacterium Tuberculosis, Metastatic Castration-Resistant Prostate Cancer (mCRPC), Mycosis Fungoides (MF), Ocular Inflammation, Ophthalmia, Sympathetic, Optic Neuritis, Pain caused by Herpes zoster, Pemphigus, Pericarditis, Pneumocystis Jirovecii Pneumonia, Polymyalgia Rheumatica (PMR), Polymyositis, Posterior Uveitis, Primary adrenocortical insufficiency, Psoriatic Arthritis, Pure Red Cell Aplasia, Regional Enteritis, Relapsing Polychondritis, Rheumatoid Arthritis, Rheumatoid Arthritis, Juvenile, Secondary adrenocortical insufficiency, Secondary thrombocytopenia, Serum Sickness, Severe Seborrheic Dermatitis, Sjogren's Syndrome (SS), Solid Organ Transplant Rejection, Stevens-Johnson Syndrome, Systemic Lupus Erythematosus, Takayasu Arteritis, Thyroid Eye Disease, Thyroiditis, Thyrotoxicosis, Trichinosis, Ulcerative Colitis, Uveitis, Vasculitis, Acquired immune hemolytic anemia, Acute Bursitis, Acute Crohn's Disease (CD), Acute Multiple sclerosis exacerbation, Acute rheumatic carditis, Anterior eye segment inflammation, Exfoliative erythroderma, Fulminating Tuberculosis, Idiopathic Bronchiolitis obliterans with organizing pneumonia, Idiopathic eosinophilic pneumonias, Non-suppurative Thyroiditis, Severe Psoriasis, Subacute Bursitis, Symptomatic Sarcoidosis, Synovitis of osteoarthritis, Systemic Dermatomyositis, Varicella-zoster virus acute retinal necrosis
Associated Therapies
Palliative Treatment

ME-401 and R-CHOP in Newly Diagnosed Diffuse Large B-Cell Lymphoma

First Posted Date
2020-08-18
Last Posted Date
2023-12-20
Lead Sponsor
Deepa Jagadeesh
Target Recruit Count
13
Registration Number
NCT04517435
Locations
🇺🇸

Cleveland Clinic Taussig Cancer institute, Case Comprehensive Cancer Center, Cleveland, Ohio, United States

A Study of Niraparib in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for the Treatment of Participants With Deleterious Germline or Somatic Homologous Recombination Repair (HRR) Gene-Mutated Metastatic Castration-Sensitive Prostate Cancer (mCSPC)

First Posted Date
2020-08-04
Last Posted Date
2024-12-06
Lead Sponsor
Janssen Research & Development, LLC
Target Recruit Count
696
Registration Number
NCT04497844
Locations
🇺🇸

Seattle Cancer Care Alliance, Seattle, Washington, United States

🇺🇸

Houston Metro Urology, Houston, Texas, United States

🇧🇪

Jolimont, Haine-St-Paul, Belgium

and more 387 locations

Cabozantinib and Abiraterone With Checkpoint Inhibitor Immunotherapy in Metastatic Hormone Sensitive Prostate Cancer (CABIOS Trial)

First Posted Date
2020-07-20
Last Posted Date
2024-11-13
Lead Sponsor
Washington University School of Medicine
Target Recruit Count
18
Registration Number
NCT04477512
Locations
🇺🇸

Washington University School of Medicine, Saint Louis, Missouri, United States

Early Use of Long-acting Tacrolimus in Lung Transplant Recipients

First Posted Date
2020-07-14
Last Posted Date
2024-01-10
Lead Sponsor
Vanderbilt University Medical Center
Target Recruit Count
48
Registration Number
NCT04469842
Locations
🇺🇸

Vanderbilt University Medical Center, Nashville, Tennessee, United States

Early Use of Corticosteroids in Non-critical Patients With COVID-19 Pneumonia

Phase 3
Terminated
Conditions
Interventions
First Posted Date
2020-06-30
Last Posted Date
2021-06-03
Lead Sponsor
University of Chile
Target Recruit Count
60
Registration Number
NCT04451174
Locations
🇨🇱

Hospital Santiago Oriente, Santiago, Peñalolen, Chile

Study of Cabozantinib in Combination With Atezolizumab Versus Second NHT in Subjects With mCRPC

First Posted Date
2020-06-24
Last Posted Date
2024-11-25
Lead Sponsor
Exelixis
Target Recruit Count
575
Registration Number
NCT04446117
Locations
🇺🇸

Exelixis Clinical Site #6, Baltimore, Maryland, United States

🇺🇸

Exelixis Clinical Site #18, Philadelphia, Pennsylvania, United States

🇵🇱

Exelixis Clinical Site #243, Otwock, Mazowieckie, Poland

and more 275 locations

Infliximab and Intravenous Immunoglobulin Therapy in Treating Patients With Steroid-Refractory Pneumonitis

First Posted Date
2020-06-18
Last Posted Date
2024-06-13
Lead Sponsor
ECOG-ACRIN Cancer Research Group
Target Recruit Count
1
Registration Number
NCT04438382
Locations
🇺🇸

Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore, Maryland, United States

🇺🇸

Mercy Health Mercy Campus, Muskegon, Michigan, United States

🇺🇸

Bronson Battle Creek, Battle Creek, Michigan, United States

and more 15 locations
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