Study of Cabozantinib in Combination With Atezolizumab Versus Second NHT in Subjects With mCRPC

Phase 3

Active, not recruiting

• Conditions: Metastatic Prostate Cancer; Prostate Adenocarcinoma
• Interventions: Drug: Abiraterone Acetate; Drug: Cabozantinib; Drug: Enzalutamide; Drug: Atezolizumab; Drug: Prednisone

• Registration Number: NCT04446117
• Lead Sponsor: Exelixis

Brief Summary

This is a Phase 3, multi-center, randomized, open-label, controlled study designed to evaluate the safety and efficacy of cabozantinib given in combination with atezolizumab versus a second novel hormonal therapy (NHT) in men with metastatic castration-resistant prostate cancer (mCRPC) who have previously been treated with one, and only one, NHT for their prostate cancer disease.

Detailed Description

The primary objective of this study is to evaluate the efficacy of cabozantinib (XL184) in combination with atezolizumab versus a second NHT (abiraterone or enzalutamide) in subjects with mCRPC who have previously been treated with one, and only one, NHT (e.g. abiraterone, apalutamide, darolutamide, or enzalutamide) to treat metastatic castration-sensitive prostate cancer (mCSPC), non-metastatic CRPC (M0 CRPC), or mCRPC, and who have measurable extrapelvic disease. The multiple primary efficacy endpoints comparing the experimental arm and control arm are Duration of Progression Free Survival (PFS) per RECIST 1.1 by Blinded Independent Radiology Committee (BIRC) and Duration of Overall Survival (OS). The secondary efficacy endpoint is Objective Response Rate (ORR) per RECIST 1.1 per BIRC.

Study Timeline

• Study First Submitted: 2020-06-22
• Study First Submitted QC: 2020-06-22
• Study First Posted: 2020-06-24
• Study Start: 2020-06-30
• Primary Completion: 2024-04-19
• Status Verified: 2024-11
• Last Update Submitted: 2024-11-21
• Last Update Posted: 2024-11-25
• Study Completion: 2026-10-16

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: Male
• Target Recruitment: 575

Inclusion Criteria

• Men with histologically or cytologically confirmed adenocarcinoma of the prostate
• Prior treatment with one, and only one, NHT (eg, abiraterone, apalutamide, darolutamide, or enzalutamide) for castration-sensitive locally advanced (T3 or T4) or mCSPC, M0 CRPC, or mCRPC
• Surgical or medical castration, with serum testosterone ≤ 50 ng/dL (≤ 1.73 nmol/L) at screening
• Measurable (extrapelvic soft tissue) metastatic disease per Investigator assessment defined by at least one of the following: measurable visceral disease (eg, adrenal, kidney, liver, lung, pancreas, spleen) per RECIST 1.1; OR measurable extrapelvic adenopathy (ie, adenopathy above the aortic bifurcation)
• Progressive disease at study entry as defined by specific criteria for prostate specific antigen (PSA) progression OR soft tissue disease progression in the opinion of the Investigator (Note: subjects with bone disease progression alone are not eligible)
• Age ≥ 18 years old or meeting country definition of adult, whichever is older, on the day of consent
• ECOG performance status of 0 or 1
• Recovery to baseline or ≤ Grade 1 per Common Terminology Criteria for Adverse Events (CTCAE) v5 from toxicities related to any prior treatments, unless AE(s) are clinically nonsignificant and/or stable on supportive therapy in the opinion of the Investigator
• Adequate organ and marrow function based upon specific laboratory assessments obtained within 21 days prior to randomization
• Understanding and ability to comply with protocol requirements

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Exclusion Criteria

• Any prior nonhormonal therapy initiated for the treatment of mCRPC
• Receipt of abiraterone within 1 week; cyproterone within 10 days; or flutamide, nilutamide, bicalutamide, enzalutamide, or other androgen-receptor inhibitors within 2 weeks before randomization
• Radiation therapy within 4 weeks (2 weeks for bone metastases) prior to randomization (subjects with clinically relevant ongoing complications from prior radiation therapy are not eligible)
• Known brain metastases or cranial epidural disease unless adequately treated and clinically stable at least 4 weeks prior to randomization
• Symptomatic or impending spinal cord compression or cauda equina syndrome
• Concomitant anticoagulation with oral anticoagulants (some specific exceptions apply)
• Administration of a live, attenuated vaccine within 30 days prior to randomization
• Systematic treatment with, or any condition requiring, either corticosteroids (>10 mg daily prednisone equivalent) or other immunosuppressive medications within 14 days prior to randomization
• Uncontrolled, significant intercurrent or recent illness
• Major surgery within 4 weeks prior to randomization
• Corrected QT interval calculated by the Fridericia formula (QTcF) > 480 ms per ECG within 21 days before randomization
• Inability or unwillingness to swallow pills or receive IV administration
• Previously identified allergy or hypersensitivity to components of the study treatment formulations or history of severe infusion-related reactions to monoclonal antibodies
• Any other active malignancy at time of randomization or diagnosis of another malignancy within 2 years prior to randomization that requires active treatment (some exceptions apply such as locally curable cancers that have apparently been cured).

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Control Arm	Abiraterone Acetate	Subjects with mCRPC will receive active comparator of EITHER abiraterone 1000mg oral, qd + prednisone 5 mg oral, bid; OR enzalutamide 160mg oral, qd as designated by the Investigator prior to randomization
Control Arm	Enzalutamide	Subjects with mCRPC will receive active comparator of EITHER abiraterone 1000mg oral, qd + prednisone 5 mg oral, bid; OR enzalutamide 160mg oral, qd as designated by the Investigator prior to randomization
Control Arm	Prednisone	Subjects with mCRPC will receive active comparator of EITHER abiraterone 1000mg oral, qd + prednisone 5 mg oral, bid; OR enzalutamide 160mg oral, qd as designated by the Investigator prior to randomization
Experimental Arm	Cabozantinib	Subjects with mCRPC will receive cabozantinib 40mg oral, qd + atezolizumab 1200mg infusion, q3w
Experimental Arm	Atezolizumab	Subjects with mCRPC will receive cabozantinib 40mg oral, qd + atezolizumab 1200mg infusion, q3w

Primary Outcome Measures

Name	Time	Method
Duration of Overall Survival (OS)	Approximately 37 months after the first subject is randomized	Defined as time from randomization to date of death from any cause
Duration of Progression Free Survival per Response Evaluable Criteria in Solid Tumors version 1.1 (RECIST 1.1)	Approximately 21 months after the first subject is randomized.	Defined as time from randomization to the earlier of progressive disease (PD) per RECIST 1.1 as determined by the Blinded Independent Radiology Committee (BIRC) or death from any cause

Secondary Outcome Measures

Name	Time	Method
Objective response rate (ORR)	Approximately 37 months after the first subject is randomized	ORR per RECIST 1.1 by BIRC

Trial Locations

Locations (278)

Exelixis Clinical Site #6; 🇺🇸 Baltimore, Maryland, United States

Exelixis Clinical Site #18; 🇺🇸 Philadelphia, Pennsylvania, United States

Exelixis Clinical Site #243; 🇵🇱 Otwock, Mazowieckie, Poland

Exelixis Clinical Site #5; 🇺🇸 Houston, Texas, United States

Exelixis Clinical Site #177; 🇺🇸 Houston, Texas, United States

Exelixis Clinical Site #259; 🇺🇸 Houston, Texas, United States

Exelixis Clinical Site #141; 🇧🇪 Brussels, Belgium

Exelixis Site #157; 🇧🇷 Porto Alegre, Rio Grande Do Sul, Brazil

Exelixis Clinical Site #180; 🇩🇪 Duisburg, North Rhine-Westphalia, Germany

Exelixis Clinical Site #254; 🇲🇽 Leon, Guanajuato, Mexico

Exelixis Clinical Site #67; 🇺🇸 Salt Lake City, Utah, United States

Exelixis Clinical Site #14; 🇺🇸 Denver, Colorado, United States

Exelixis Clinical Site #49; 🇰🇷 Goyang-si, Gyeonggi-do, Korea, Republic of

Exelixis Clinical Site #34; 🇰🇷 Hwasun, Jeollanam-do, Korea, Republic of

Exelixis Clinical Site #12; 🇪🇸 Manresa, Barcelona, Spain

Exelixis Clinical Site #233; 🇪🇸 Santiago de Compostela, La Coruna, Spain

Exelixis Clinical Site #13; 🇪🇸 Madrid, Spain

Exelixis Clinical Site #4; 🇺🇸 Tucson, Arizona, United States

Exelixis Clinical Site #2; 🇺🇸 Fullerton, California, United States

Exelixis Clinical Site #42; 🇺🇸 Duarte, California, United States

Exelixis Clinical Site #224; 🇺🇸 La Jolla, California, United States

Exelixis Clinical Site #114; 🇺🇸 San Diego, California, United States

Exelixis Clinical Site #245; 🇺🇸 Stanford, California, United States

Exelixis Clinical Site #108; 🇺🇸 Miami, Florida, United States

Exelixis Clinical Site #215; 🇺🇸 Westwood, Kansas, United States

Non-participating Site; 🇺🇸 Lawrenceville, New Jersey, United States

Exelixis Clinical Site #19; 🇺🇸 Omaha, Nebraska, United States

Exelixis Clinical Site #123; 🇺🇸 East Brunswick, New Jersey, United States

Exelixis Site #159; 🇺🇸 Cleveland, Ohio, United States

Exelixis Clinical Site #201; 🇺🇸 Pittsburgh, Pennsylvania, United States

Exelixis Clinical Site #1; 🇺🇸 Nashville, Tennessee, United States

Exelixis Clinical Site #122; 🇦🇷 Ciudad Autonoma de Buenos Aire, Buenos Aires, Argentina

Exelixis Clinical Site #41; 🇺🇸 Temple, Texas, United States

Exelixis Clinical Site #120; 🇦🇷 Mar Del Plata, Buenos Aires, Argentina

Exelixis Clinical Site #210; 🇦🇷 Córdoba, Cordoba, Argentina

Exelixis Site #170; 🇦🇷 Pergamino, Buenos Aires, Argentina

Exelixis Clinical Site #152; 🇦🇷 Viedma, Rio Negro, Argentina

Exelixis Clinical Site #272; 🇲🇽 Puebla, Mexico

Exelixis Clinical Site #249; 🇬🇧 Blackburn, Lancashire, United Kingdom

Exelixis Clinical Site #223; 🇵🇹 Porto, Portugal

Exelixis Clinical Site #44; 🇦🇷 Ciudad Autonoma de Buenos Aire, Argentina

Exelixis Clinical Site #256; 🇦🇷 Caba, Argentina

Exelixis Clinical Site #124; 🇦🇷 San Juan, Argentina

Exelixis Clinical Site #105; 🇦🇷 La Rioja, Argentina

Exelixis Site #162; 🇦🇺 Wollongong, New South Wales, Australia

Exelixis Clinical Site #253; 🇦🇺 Chermside, Queensland, Australia

Exelixis Clinical Site #103; 🇦🇺 Launceston, Tasmania, Australia

Exelixis Clinical Site #95; 🇦🇺 Frankston, Victoria, Australia

Exelixis Clinical Stie #260; 🇦🇺 Saint Albans, Victoria, Australia

Exelixis Clinical Site #115; 🇦🇺 Adelaide, Australia

Exelixis Clinical Site #149; 🇦🇺 Box Hill, Australia

Exelixis Clinical Site #126; 🇧🇪 Bonheiden, Antwerpen, Belgium

Exelixis Clinical Site #39; 🇧🇪 Gent, Oost-Vlaanderen, Belgium

Exelixis Clinical Site #218; 🇦🇹 Wien, Austria

Exelixis Site #165; 🇧🇪 Roeselare, Belgium

Exelixis Clinical Site #191; 🇧🇷 Campinas, Sao Paulo, Brazil

Exelixis Clinical Site #153; 🇧🇷 Porto Alegre, Brazil

Exelixis Clinical Site #127; 🇨🇦 London, Ontario, Canada

Exelixis Clinical Site #83; 🇨🇦 Hamilton, Ontario, Canada

Exelixis Clinical Site #178; 🇨🇦 Granby, Quebec, Canada

Exelixis Site #160; 🇨🇦 Montréal, Quebec, Canada

Exelixis Clinical Site #63; 🇨🇿 Praha 2, Praha, Czechia

Exelixis Clinical Site #129; 🇨🇿 Brno, Czechia

Exelixis Clinical Site #130; 🇨🇿 Olomouc, Czechia

Exelixis Clinical Site #31; 🇨🇿 Praha, Czechia

Exelixis Clinical Site #134; 🇫🇷 Brest, France

Exelixis Clinical Site #77; 🇫🇷 Clermont-Ferrand, France

Exelixis Clinical Site #155; 🇫🇷 Dijon cedex, France

Exelixis Clinical Site #74; 🇫🇷 Hyères, France

Exelixis Clinical Site #222; 🇫🇷 La Roche-sur-Yon Cedex 9, France

Exelixis Clinical Site #38; 🇫🇷 Paris, France

Exelixis Clinical Site #66; 🇫🇷 Quimper, France

Exelixis Clinical Site #146; 🇫🇷 Nîmes, France

Exelixis Clinical Site #214; 🇫🇷 Reims, France

Exelixis Clinical Site #135; 🇫🇷 Saint-Grégoire, France

Exelixis Clinical Site #213; 🇫🇷 Strasbourg, France

Exelixis Clinical Site #36; 🇫🇷 Strasbourg, France

Exelixis Clinical Site #85; 🇫🇷 Toulouse, France

Exelixis Clinical Site #73; 🇫🇷 Toulouse, France

Exelixis Clinical Site #10; 🇬🇪 Tbilisi, Georgia

Exelixis Clinical Site #15; 🇬🇪 Tbilisi, Georgia

Exelixis Clinical Site #8; 🇬🇪 Tbilisi, Georgia

Exelixis Clinical Site #11; 🇬🇪 Tbilisi, Georgia

Exelixis Clinical Site #179; 🇩🇪 Münster, North Rhine-Westphalia, Germany

Exelixis Clinical Site #185; 🇩🇪 Lübeck, Schleswig-Holstein, Germany

Exelixis Clinical Site #239; 🇩🇪 Hamburg, Germany

Exelixis Clinical Site #227; 🇩🇪 Berlin, Germany

Exelixis Clinical Site #136; 🇩🇪 Tübingen, Germany

Exelixis Clinical Site #273; 🇩🇪 Hannover, Germany

Exelixis Clinical Site #202; 🇬🇷 Maroussi, Attica, Greece

Exelixis Clinical Site #238; 🇬🇷 Athens, Attica, Greece

Exelixis Clinical Site #92; 🇬🇷 Maroúsi, Attica, Greece

Exelixis Clinical Site #244; 🇬🇷 Nea Kifisia, Attica, Greece

Exelixis Clinical Site #99; 🇬🇷 Néo Fáliro, Attica, Greece

Exelixis Clinical Site #45; 🇬🇷 Heraklion, Crete, Greece

Exelixis Clinical Site #64; 🇬🇷 Thessaloníki, Macedonia, Greece

Exelixis Clinical Site #97; 🇬🇷 Larissa, Thessaly, Greece

Exelixis Clinical Site #109; 🇭🇺 Budapest, Hungary

Exelixis Clinical Site #240; 🇭🇺 Debrecen, Hungary

Exelixis Clinical Site #207; 🇭🇺 Budapest, Hungary

Exelixis Clinical Site #27; 🇮🇱 Jerusalem, Israel

Exelixis Clinical Site #150; 🇮🇱 Petah tikva, Israel

Exelixis Clinical Site #117; 🇮🇱 Ramat Gan, Israel

Exelixis Site #168; 🇮🇹 Meldola, FC, Italy

Exelixis Clinical Site #246; 🇮🇹 Rozzano, Milano, Italy

Exelixis Clinical Site #217; 🇮🇹 Ancona, Italy

Exelixis Clinical Site #121; 🇮🇹 Firenze, Italy

Exelixis Clinical Site #258; 🇮🇹 Milano, Italy

Exelixis Clinical Site #237; 🇮🇹 Pavia, Italy

Exelixis Clinical Site #192; 🇮🇹 Milan, Italy

Exelixis Clinical #267; 🇮🇹 Parma, Italy

Exelixis Clinical Site #107; 🇮🇹 Perugia, Italy

Exelixis Clinical Site #62; 🇮🇹 Roma, Italy

Exelixis Clinical #269; 🇮🇹 Pisa, Italy

Exelixis Clinical Site #234; 🇮🇹 Roma, Italy

Exelixis Clinical Site #96; 🇮🇹 Terni, Italy

Exelixis Clinical Site #232; 🇯🇵 Toyota-shi, Aichi, Japan

Exelixis Clinical Site #100; 🇯🇵 Akita-Shi, Akita, Japan

Exelixis Clinical Site #104; 🇯🇵 Hirosaki, Aomori, Japan

Exelixis Clinical Site #54; 🇯🇵 Sakura-shi, Chiba, Japan

Exelixis Clinical Site #43; 🇯🇵 Kashiwa-shi, Chiba, Japan

Exelixis Clinical Site #84; 🇯🇵 Kita-gun, Kagawa, Japan

Exelixis Clinical Site #211; 🇯🇵 Natori-shi, Miyagi, Japan

Exelixis Clinical Site #88; 🇯🇵 Chuo-Ku, Osaka-shi, Japan

Exelixis Clinical Site #51; 🇯🇵 Hidaka, Saitama, Japan

Exelixis Clinical Site #216; 🇯🇵 Shizuoka City, Shizuoka, Japan

Exelixis Clinical Site #78; 🇯🇵 Chiba, Japan

Exelixis Clinical Site #209; 🇯🇵 Fukuoka, Japan

Exelixis Clinical Site #61; 🇯🇵 Ube, Yamaguchi, Japan

Exelixis Clinical Site #75; 🇯🇵 Tokyo, Japan

Exelixis Clinical Site #32; 🇯🇵 Wakayama, Japan

Exelixis Clinical Site #26; 🇯🇵 Nagano, Japan

Exelixis Clinical Site #81; 🇯🇵 Ōsaka-sayama, Japan

Exelixis Clinical Site #58; 🇰🇷 Busan, Korea, Republic of

Exelixis Clinical Site #60; 🇰🇷 Seongnam-si, Gyeonggi-Do, Korea, Republic of

Exelixis Clinical Site #24; 🇰🇷 Busan, Korea, Republic of

Exelixis Clinical Site #94; 🇰🇷 Daegu, Korea, Republic of

Exelixis Clinical Site #21; 🇰🇷 Daegu, Korea, Republic of

Exelixis Clinical Site #40; 🇰🇷 Gwangju, Korea, Republic of

Exelixis Clinical Site #59; 🇰🇷 Seoul, Korea, Republic of

Exelixis Clinical Site #46; 🇰🇷 Seoul, Korea, Republic of

Exelixis Clinical Site #212; 🇲🇽 Guadalajara, Jalisco, Mexico

Exelixis Clinical Site #208; 🇲🇽 Culiacán, Sinaloa, Mexico

Exelixis Clinical Site #250; 🇲🇽 San Luis Potosí, San Luis Potosi, Mexico

Exelixis Clinical Site #174; 🇲🇽 Mexico City, Mexico

Exelixis Clinical Site #110; 🇵🇹 Braga, Portugal

Exelixis Clinical Site #89; 🇵🇱 Poznań, Poland

Exelixis Clinical Site #188; 🇵🇹 Guimarães, Portugal

Exelixis Site #164; 🇵🇹 Lisboa, Portugal

Exelixis Clinical Site #197; 🇵🇹 Lisboa, Portugal

Exelixis Clinical Site #56; 🇵🇹 Porto, Portugal

Exelixis Clinical Site #193; 🇵🇹 Vila Real, Portugal

Exelixis Site #166; 🇷🇺 Moscow, Russian Federation

Exelixis Clinical Site #181; 🇸🇬 Singapore, Singapore

Exelixis Clinical Site #50; 🇸🇬 Singapore, Singapore

Exelixis Clinical Site #195; 🇷🇺 Saint Petersburg, Russian Federation

Exelixis Clinical Site #229; 🇪🇸 Elche, Alicante, Spain

Exelixis Clinical Site #220; 🇪🇸 Palma De Mallorca, Islas Baleares, Spain

Exelixis Clinical Site #17; 🇪🇸 Alcorcón, Madrid, Spain

Exelixis Clinical Site #274; 🇪🇸 Badalona, Spain

Exelixis Clinical Site #23; 🇪🇸 Barcelona, Spain

Exelixis Clinical Site #190; 🇪🇸 Barcelona, Spain

Exelixis Clinical Site #228; 🇪🇸 Barcelona, Spain

Exelixis Clinical Site #33; 🇪🇸 Córdoba, Spain

Exelixis Clinical Site #28; 🇪🇸 Lugo, Spain

Exelixis Clinical Site #131; 🇪🇸 Madrid, Spain

Exelixis Clinical Site #248; 🇪🇸 Madrid, Spain

Exelixis Clinical Site #236; 🇪🇸 Madrid, Spain

Exelixis Clinical Site #251; 🇪🇸 Madrid, Spain

Exelixis Clinical #270; 🇪🇸 Málaga, Spain

Exelixis Clinical Site #133; 🇨🇳 Taichung, Taiwan

Exelixis Clinical Site #138; 🇨🇳 Kaohsiung, Taiwan

Exelixis Clinical Site #29; 🇪🇸 Sevilla, Spain

Exelixis Clinical Site #86; 🇨🇳 Taichung City, Taiwan

Exelixis Clinical #266; 🇨🇳 Kaohsiung, Taiwan

Exelixis Clinical Site #271; 🇨🇳 Tainan City, Taiwan

Exelixis Clinical Site #111; 🇨🇳 Tainan, Taiwan

Exelixis Clinical Site #102; 🇺🇦 Dnipro, Ukraine

Exelixis Clinical #264; 🇨🇳 Taipei city, Taiwan

Exelixis Clinical #265; 🇨🇳 Taoyuan, Taiwan

Exelixis Clinical Site #186; 🇺🇦 Dnipro, Ukraine

Exelixis Clinical Site #71; 🇺🇦 Luts'k, Ukraine

Exelixis Clinical Site #76; 🇺🇦 Kyiv, Ukraine

Exelixis Clinical Site #235; 🇬🇧 Surrey Quays, England, United Kingdom

Exelixis Clinical Site #231; 🇬🇧 Northwood, Middlesex, United Kingdom

Exelixis Clinical Site #203; 🇺🇸 Rochester, Minnesota, United States

Exelixis Clinical Site #221; 🇺🇸 Oklahoma City, Oklahoma, United States

Exelixis Clinical Site #79; 🇦🇺 Ballarat, Victoria, Australia

Exelixis Clinical Site # 189; 🇦🇺 Sydney, New South Wales, Australia

Exelixis Clinical Site #101; 🇦🇷 San Salvador De Jujuy, Argentina

Exelixis Clinical Site #91; 🇺🇸 Aurora, Colorado, United States

Exelixis Clinical Site #25; 🇰🇷 Seoul, Korea, Republic of

Exelixis Clinical Site #125; 🇺🇸 Santa Monica, California, United States

Winship Cancer Institute of Emory University; 🇺🇸 Atlanta, Georgia, United States

Exelixis Clinical Site #144; 🇺🇸 Las Vegas, Nevada, United States

Weill Cornell Medical College; 🇺🇸 New York, New York, United States

Exelixis Clinical Site #183; 🇦🇷 Rosario, Santa Fe, Argentina

Exelixis Clinical Site #200; 🇦🇷 Buenos Aires, Argentina

Exelixis Clinical #261; 🇦🇷 Rosario, Santa Fe, Argentina

Exelixis Clinical Site #175; 🇦🇺 Saint Leonards, New South Wales, Australia

Exelixis Clinical Site #252; 🇦🇺 Port Macquarie, New South Wales, Australia

Exelixis Clinical #262; 🇦🇺 Geelong, Victoria, Australia

Exelixis Clinical Site #53; 🇦🇺 Melbourne, Victoria, Australia

Exelixis Site #163; 🇧🇷 Curitiba, Paraná, Brazil

Exelixis Clinical Site #204; 🇧🇷 Curitiba, Parana, Brazil

Exelixis Clinical Site #171; 🇧🇷 Rio De Janeiro, RJ, Brazil

Exelixis Site #161; 🇧🇷 Sao Paulo, SP, Brazil

Exelixis Clinical Site #128; 🇧🇷 Ribeirão Preto, São Paulo, Brazil

Exelixis Clinical Site #154; 🇧🇷 Barretos, Brazil

Exelixis Clinical Site #140; 🇧🇷 Fortaleza, Brazil

Exelixis Clinical Site #106; 🇧🇷 São José Do Rio Preto, São Paulo, Brazil

Exelixis Clinical Site #145; 🇧🇷 Ribeirão Preto, Brazil

Exelixis Clinical Site #147; 🇨🇦 Moncton, New Brunswick, Canada

Exelixis Clinical Site #112; 🇨🇦 Kelowna, British Columbia, Canada

Exelixis Clinical Site #116; 🇧🇷 Santa Cruz Do Sul, Brazil

Exelixis Clinical Site #7; 🇨🇦 Oakville, Ontario, Canada

Exelixis Clinical Site #247; 🇨🇱 Viña del Mar, Región De Valparaíso, Chile

Exelixis Clinical Site #148; 🇨🇱 Recoleta, Chile

Exelixis Clinical Site #90; 🇨🇱 Santiago, Chile

Exelixis Clinical Site #142; 🇨🇱 Providencia, Chile

Exelixis Clinical Site #113; 🇨🇱 Temuco, Chile

Exelixis Clinical Site #119; 🇨🇱 Valparaíso, Chile

Exelixis Clinical Site #80; 🇨🇿 Praha 2, Czechia

Exelixis Clinical Site #47; 🇨🇿 Praha 8, Czechia

Exelixis Clinical Site #93; 🇬🇷 Cholargós, Attica, Greece

Exelixis Clinical Site #230; 🇫🇷 Vandoeuvre les nancy, France

Exelixis Clinical Site #98; 🇩🇪 Gutersloh, Nordrhein-Westfalen, Germany

Exelixis Clinical Site #176; 🇩🇪 Nürtingen, Baden-Wuerttemberg, Germany

Exelixis Clinical Site #57; 🇭🇺 Budapest, Hungary

Exelixis Clinical Site #118; 🇭🇺 Budapest, Hungary

Exelixis site #167; 🇭🇺 Gyula, Hungary

Exelixis Clinical Site #55; 🇮🇱 Haifa, Israel

Exelixis Clinical Site #30; 🇮🇱 Safed, Israel

Exelixis Clinical Site #35; 🇮🇱 Tel Aviv, Israel

Exelixis Site #156; 🇮🇹 Sondrio, SO, Italy

Exelixis Clinical Site #199; 🇮🇹 Trento, Trentino, Italy

Exelixis Clinical Site #72; 🇯🇵 Sapporo, Hokkaido, Japan

Exelixis Clinical Site #37; 🇯🇵 Sapporo, Hokkaido, Japan

Exelixis Clinical Site #52; 🇯🇵 Kobe, Hyogo, Japan

Exelixis Clinical Site #70; 🇯🇵 Kobe, Hyogo, Japan

Exelixis Clinical Site #22; 🇯🇵 Yokohama-shi, Kanagawa, Japan

Exelixis Clinical Site #68; 🇯🇵 Sagamihara, Kanagawa, Japan

Exelixis Clinical Site #20; 🇰🇷 Junggu, Daejeon, Korea, Republic of

Exelixis Clinical Site #48; 🇰🇷 Seoul, Korea, Republic of

Exelixis Clinical Site #173; 🇲🇽 Guadalajara, Jalisco, Mexico

Exelixis Clinical Site #219; 🇲🇽 Zapopan, Jalisco, Mexico

Exelixis Clinical #268; 🇵🇱 Łódź, Poland

Exelixis Clinical Site #82; 🇵🇱 Bydgoszcz, Poland

Exelixis Clinical Site #137; 🇷🇺 Saint Petersburg, Russian Federation

Exelixis Clinical Site #87; 🇸🇬 Singapore, Singapore

Exelixis Clinical Site #255; 🇪🇸 Barcelona, Spain

Exelixis Clinical Site #226; 🇪🇸 Cadiz, Spain

Exelixis Clinical Site #205; 🇬🇧 London, England, United Kingdom

Exelixis Clinical Site #156; 🇦🇹 Linz, Oberösterreich, Austria

Exelixis Clinical #263; 🇨🇱 Santiago, Región Metropolitana, Chile

Exelixis Clinical Site #184; 🇲🇽 San Luis Potosí, San Luis Potosi, Mexico

Exelixis Site #158; 🇦🇹 Linz, Oberösterreich, Austria

Exelixis Clinical Site #9; 🇬🇪 Tbilisi, Georgia

Exelixis Clinical Site #132; 🇧🇷 Blumenau, Santa Catarina, Brazil

Exelixis Clinical Site #151; 🇦🇺 Garran, Australian Capital Territory, Australia

Exelixis Clinical Site #139; 🇨🇱 Santiago de Chile, Región Metropolitana De Santiago, Chile

Exelixis Clinical Site #16; 🇬🇪 Tbilisi, Georgia

Exelixis Clinical Site #241; 🇬🇧 Taunton, England, United Kingdom

Exelixis Clinical Site #257; 🇲🇽 Monterrey, Nuevo Leon, Mexico

Exelixis Clinical Site #172; 🇲🇽 Querétaro, Queretaro, Mexico

Exelixis Clinical Site #182; 🇲🇽 Querétaro, Queretaro, Mexico

Exelixis Clinical Site #196; 🇵🇹 Loures, Portugal

Exelixis Clinical Site #206; 🇲🇽 Tuxtla Gutiérrez, Chiapas, Mexico

Exelixis Clinical Site #187; 🇲🇽 Mexico City, Distrito Federal, Mexico

Exelixis Clinical Site #225; 🇪🇸 Oviedo, Asturias, Spain

Exelixis Clinical Site #65; 🇯🇵 Shinjuku-Ku, Tokyo, Japan

Exelixis Clinical Site #194; 🇬🇧 Swansea, Wales, United Kingdom

Yale University School of Medicine; 🇺🇸 New Haven, Connecticut, United States

Yale University, School of Medicine; 🇺🇸 New Haven, Connecticut, United States

Exelixis Clinical Site #242; 🇺🇸 Louisville, Kentucky, United States

Exelixis Clinical Site #198; 🇺🇸 Bronx, New York, United States

Exelixis Clinical Site #69; 🇨🇦 Edmonton, Alberta, Canada

Exelixis Clinical Site #143; 🇺🇸 Roanoke, Virginia, United States