Prednisone

Generic Name: Prednisone

Brand Names: Deltasone, Rayos, Winpred

Drug Type: Small Molecule

Chemical Formula: C_₂₁H_₂₆O_₅

CAS Number: 53-03-2

Unique Ingredient Identifier: VB0R961HZT

Background: A synthetic anti-inflammatory glucocorticoid derived from cortisone. It is biologically inert and converted to prednisolone in the liver.

Prednisone was granted FDA approval on 21 February 1955.

Indication: Prednisone is indicated as an anti-inflammatory or immunosuppressive drug for allergic, dermatologic, gastrointestinal, hematologic, ophthalmologic, nervous system, renal, respiratory, rheumatologic, infectious, endocrine, or neoplastic conditions as well as in organ transplant.

Associated Conditions: Acne Vulgaris, Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Acute Gouty Arthritis, Acute Leukemia, Aggressive Lymphoma, Allergic Bronchopulmonary Aspergillosis, Allergic Conjunctivitis (AC), Allergic Rhinitis (AR), Allergic corneal marginal ulcers, Alveolitis, Extrinsic Allergic, Ankylosing Spondylitis (AS), Aspiration Pneumonitis, Asthma, Atopic Dermatitis, Autoimmune Hepatitis, Bell's Palsy, Berylliosis, Bullous dermatitis herpetiformis, Chorioretinitis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Contact Dermatitis, Disseminated tuberculosis, Drug hypersensitivity reaction, Edema of the cerebrum, Epicondylitis, Erythroblastopenia, Giant Cell Arteritis (GCA), Hypercalcemia of Malignancy, Idiopathic Pulmonary Fibrosis (IPF), Immune Thrombocytopenia (ITP), Iridocyclitis, Iritis, Keratitis, Leukemias, Loeffler's syndrome, Lymphoma, Meningitis caused by Mycobacterium Tuberculosis, Metastatic Castration-Resistant Prostate Cancer (mCRPC), Mycosis Fungoides (MF), Ocular Inflammation, Ophthalmia, Sympathetic, Optic Neuritis, Pain caused by Herpes zoster, Pemphigus, Pericarditis, Pneumocystis Jirovecii Pneumonia, Polymyalgia Rheumatica (PMR), Polymyositis, Posterior Uveitis, Primary adrenocortical insufficiency, Psoriatic Arthritis, Pure Red Cell Aplasia, Regional Enteritis, Relapsing Polychondritis, Rheumatoid Arthritis, Rheumatoid Arthritis, Juvenile, Secondary adrenocortical insufficiency, Secondary thrombocytopenia, Serum Sickness, Severe Seborrheic Dermatitis, Sjogren's Syndrome (SS), Solid Organ Transplant Rejection, Stevens-Johnson Syndrome, Systemic Lupus Erythematosus, Takayasu Arteritis, Thyroid Eye Disease, Thyroiditis, Thyrotoxicosis, Trichinosis, Ulcerative Colitis, Uveitis, Vasculitis, Acquired immune hemolytic anemia, Acute Bursitis, Acute Crohn's Disease (CD), Acute Multiple sclerosis exacerbation, Acute rheumatic carditis, Anterior eye segment inflammation, Exfoliative erythroderma, Fulminating Tuberculosis, Idiopathic Bronchiolitis obliterans with organizing pneumonia, Idiopathic eosinophilic pneumonias, Non-suppurative Thyroiditis, Severe Psoriasis, Subacute Bursitis, Symptomatic Sarcoidosis, Synovitis of osteoarthritis, Systemic Dermatomyositis, Varicella-zoster virus acute retinal necrosis

Associated Therapies: Palliative Treatment

Clinical Trials

Treatment for Classical Hodgkin Lymphoma in Children and Adolescents

Not Applicable

Recruiting

Conditions: Classical Hodgkins Lymphoma in Children and Adolescents.

Interventions: Drug: Vincristine
Drug: Prednisone
Drug: Etoposide
Drug: Dacarbazine
Drug: Cyclophosphamide
Drug: Doxorubicin

First Posted Date: 2016-06-13

Last Posted Date: 2016-06-14

Lead Sponsor: GALIA AVRAHAMI

Target Recruit Count: 2200

Registration Number: NCT02797717

Locations: 🇮🇱
Schneider children's medical center, Petach-Tikva, Israel

Neoadjuvant Androgen Deprivation Therapy Plus Abiraterone With or Without Apalutamide for High-Risk Prostate Cancer

Phase 2

Completed

Conditions: Prostate Cancer

Interventions: Drug: Goserelin
Drug: Prednisone
Drug: Abiraterone
Drug: Apalutamide

First Posted Date: 2016-06-03

Last Posted Date: 2022-09-15

Lead Sponsor: Instituto do Cancer do Estado de São Paulo

Target Recruit Count: 64

Registration Number: NCT02789878

Locations: 🇧🇷
Instituto do Cancer do Estado de Sao Paulo, Sao Paulo, SP, Brazil

Effect of Corticosteroids on Inflammation at the Edge of Acute Multiple Sclerosis Plaques

Phase 2

Recruiting

Conditions: Multiple Sclerosis

Interventions: Drug: Methylprednisolone
Drug: Prednisone

First Posted Date: 2016-05-27

Last Posted Date: 2024-11-11

Lead Sponsor: National Institute of Neurological Disorders and Stroke (NINDS)

Target Recruit Count: 30

Registration Number: NCT02784210

Locations: 🇺🇸
National Institutes of Health Clinical Center, Bethesda, Maryland, United States

Steroids in Children Hospitalized With Asthma

Phase 4

Terminated

Conditions: Asthma
Status Asthmaticus
Wheezes

Interventions: Drug: Dexamethasone
Drug: Prednisone

First Posted Date: 2016-05-23

Last Posted Date: 2019-06-21

Lead Sponsor: University of Florida

Target Recruit Count: 6

Registration Number: NCT02780479

Locations: 🇺🇸
Wolfson Children Hospital, Jacksonville, Florida, United States

Reducing Dexamethasone Around Docetaxel Infusion

Phase 1

Conditions: Breast Cancer
Prostate Cancer

Interventions: Drug: Dexamethasone
Drug: Prednisone

First Posted Date: 2016-05-18

Last Posted Date: 2021-04-02

Lead Sponsor: Leiden University Medical Center

Target Recruit Count: 46

Registration Number: NCT02776436

Locations: 🇳🇱
Haga hospital, Den Haag, Netherlands
🇳🇱
Reinier de Graaf hospital, Delft, Netherlands
🇳🇱
Leiden university medical center, Leiden, Netherlands

Ponatinib With Chemotherapy for Young Adults Ph Positive Acute Lymphoblastic Leukemia

Phase 2

Conditions: ALL

Interventions: Drug: Prednisone
Drug: Vincristine
Drug: Daunorubicin
Drug: Ponatinib
Drug: Mercaptopurine
Drug: Methotrexate
Drug: VP-16
Drug: TIT
Procedure: Autologous transplantation
Procedure: Allo transplantation

First Posted Date: 2016-05-18

Last Posted Date: 2022-02-18

Lead Sponsor: PETHEMA Foundation

Target Recruit Count: 30

Registration Number: NCT02776605

Locations: 🇪🇸
Hospital Clinic, Barcelona, Spain
🇪🇸
Hospital Germans Trias i Pujol, Badalona, Spain
🇪🇸
Hospital 12 de Octubre, Madrid, Spain

and more 7 locations

Treatment With a Scheme With Low Doses of Bortezomib / Melphalan / Prednisone (MPV) in Patients With Multiple Myeloma

Phase 4

Terminated

Conditions: Multiple Myeloma

Interventions: Drug: Bortezomib
Drug: Melphalan
Drug: Prednisone

First Posted Date: 2016-05-16

Last Posted Date: 2020-01-18

Lead Sponsor: Basque Health Service

Target Recruit Count: 24

Registration Number: NCT02773550

Locations: 🇪🇸
Araba of University Hospital, Vitoria-Gasteiz, Araba, Spain

Trial of R-GemOx Versus R-miniCHOP Regimen in First-line Treatment of Elderly Diffuse Large B Cell Lymphoma

Phase 3

Conditions: Diffuse Large B Cell Lymphoma

Interventions: Drug: Rituximab
Drug: Cyclophosphamide
Drug: Gemcitabine
Drug: Epirubicin Injectable Product
Drug: Oxaliplatin
Drug: Vindesine
Drug: Prednisone

First Posted Date: 2016-05-10

Last Posted Date: 2019-01-03

Lead Sponsor: The First Affiliated Hospital with Nanjing Medical University

Target Recruit Count: 258

Registration Number: NCT02767674

Locations: 🇨🇳
Shandong Province Hospital, Jinan, Shandong, China
🇨🇳
Tongji Medical College of HUST, Wuhan, Hubei, China
🇨🇳
The first Affiliated Hospital Of Nanjing Medical University(JiangSu Province Hospital), NanJing, Jiangsu, China

and more 3 locations