Prednisone

Generic Name: Prednisone

Brand Names: Deltasone, Rayos, Winpred

Drug Type: Small Molecule

Chemical Formula: C_₂₁H_₂₆O_₅

CAS Number: 53-03-2

Unique Ingredient Identifier: VB0R961HZT

Background: A synthetic anti-inflammatory glucocorticoid derived from cortisone. It is biologically inert and converted to prednisolone in the liver.

Prednisone was granted FDA approval on 21 February 1955.

Indication: Prednisone is indicated as an anti-inflammatory or immunosuppressive drug for allergic, dermatologic, gastrointestinal, hematologic, ophthalmologic, nervous system, renal, respiratory, rheumatologic, infectious, endocrine, or neoplastic conditions as well as in organ transplant.

Associated Conditions: Acne Vulgaris, Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Acute Gouty Arthritis, Acute Leukemia, Aggressive Lymphoma, Allergic Bronchopulmonary Aspergillosis, Allergic Conjunctivitis (AC), Allergic Rhinitis (AR), Allergic corneal marginal ulcers, Alveolitis, Extrinsic Allergic, Ankylosing Spondylitis (AS), Aspiration Pneumonitis, Asthma, Atopic Dermatitis, Autoimmune Hepatitis, Bell's Palsy, Berylliosis, Bullous dermatitis herpetiformis, Chorioretinitis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Contact Dermatitis, Disseminated tuberculosis, Drug hypersensitivity reaction, Edema of the cerebrum, Epicondylitis, Erythroblastopenia, Giant Cell Arteritis (GCA), Hypercalcemia of Malignancy, Idiopathic Pulmonary Fibrosis (IPF), Immune Thrombocytopenia (ITP), Iridocyclitis, Iritis, Keratitis, Leukemias, Loeffler's syndrome, Lymphoma, Meningitis caused by Mycobacterium Tuberculosis, Metastatic Castration-Resistant Prostate Cancer (mCRPC), Mycosis Fungoides (MF), Ocular Inflammation, Ophthalmia, Sympathetic, Optic Neuritis, Pain caused by Herpes zoster, Pemphigus, Pericarditis, Pneumocystis Jirovecii Pneumonia, Polymyalgia Rheumatica (PMR), Polymyositis, Posterior Uveitis, Primary adrenocortical insufficiency, Psoriatic Arthritis, Pure Red Cell Aplasia, Regional Enteritis, Relapsing Polychondritis, Rheumatoid Arthritis, Rheumatoid Arthritis, Juvenile, Secondary adrenocortical insufficiency, Secondary thrombocytopenia, Serum Sickness, Severe Seborrheic Dermatitis, Sjogren's Syndrome (SS), Solid Organ Transplant Rejection, Stevens-Johnson Syndrome, Systemic Lupus Erythematosus, Takayasu Arteritis, Thyroid Eye Disease, Thyroiditis, Thyrotoxicosis, Trichinosis, Ulcerative Colitis, Uveitis, Vasculitis, Acquired immune hemolytic anemia, Acute Bursitis, Acute Crohn's Disease (CD), Acute Multiple sclerosis exacerbation, Acute rheumatic carditis, Anterior eye segment inflammation, Exfoliative erythroderma, Fulminating Tuberculosis, Idiopathic Bronchiolitis obliterans with organizing pneumonia, Idiopathic eosinophilic pneumonias, Non-suppurative Thyroiditis, Severe Psoriasis, Subacute Bursitis, Symptomatic Sarcoidosis, Synovitis of osteoarthritis, Systemic Dermatomyositis, Varicella-zoster virus acute retinal necrosis

Associated Therapies: Palliative Treatment

Clinical Trials

Effects of p38 Inhibitor AZD7624 in Corticosteroid Resistant Asthma

Phase 2

Completed

Conditions: Corticosteroid Resistant (CR) Asthmatics

Interventions: Drug: prednisone
Drug: AZD7624
Drug: Placebo

First Posted Date: 2016-04-28

Last Posted Date: 2019-08-21

Lead Sponsor: National Jewish Health

Target Recruit Count: 2

Registration Number: NCT02753764

Locations: 🇺🇸
National Jewish Health, Denver, Colorado, United States

Chidamide Plus R-CHOP in Elderly DLBCL

Phase 2

Conditions: Diffuse Large B-cell Lymphoma

Interventions: Drug: Rituximab
Drug: Cyclophosphamide
Drug: Doxorubicin
Drug: Vincristine
Drug: Prednisone
Drug: Chidamide

First Posted Date: 2016-04-28

Last Posted Date: 2017-11-14

Lead Sponsor: Ruijin Hospital

Target Recruit Count: 49

Registration Number: NCT02753647

Locations: 🇨🇳
Shanghai Ruijin Hospital, Shanghai, Shanghai, China

Reduced Chemotherapy in Low Risk DLBCL

Phase 4

Active, not recruiting

Conditions: Diffuse Large B-cell Lymphoma

Interventions: Drug: Rituximab
Drug: Cyclophosphamide
Drug: Epirubicin
Drug: Vincristine
Drug: Prednisone

First Posted Date: 2016-04-27

Last Posted Date: 2022-12-05

Lead Sponsor: Ruijin Hospital

Target Recruit Count: 290

Registration Number: NCT02752815

Locations: 🇨🇳
Shanghai Ruijin Hospital, Shanghai, Shanghai, China

Perioperative Oral Steroids for Chronic Rhinosinusitis Without Polyps (CRSsNP)

Not Applicable

Completed

Conditions: Endoscopic Sinus Surgery
Oral Steroids
Chronic Rhinosinusitis Without Polyps
Chronic Rhinosinusitis

Interventions: Drug: Flonase
Drug: Prednisone

First Posted Date: 2016-04-22

Last Posted Date: 2020-08-04

Lead Sponsor: Stanford University

Target Recruit Count: 81

Registration Number: NCT02748070

Locations: 🇺🇸
Stanford University, Stanford, California, United States

A Study of Brentuximab Vedotin, Rituximab, and Dose Attenuated CHP in Elderly Patients With Diffuse Large B-Cell Lymphoma (DLBCL)

Phase 2

Active, not recruiting

Conditions: Diffuse Large B-Cell Lymphoma

Interventions: Drug: Brentuximab vedotin
Drug: Rituximab
Drug: Cyclophosphamide
Drug: Doxorubicin
Drug: Prednisone

First Posted Date: 2016-04-12

Last Posted Date: 2024-08-06

Lead Sponsor: Patrick Reagan

Target Recruit Count: 24

Registration Number: NCT02734771

Locations: 🇺🇸
University of Virginia Cancer Center, Charlottesville, Virginia, United States
🇺🇸
James P. Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, New York, United States

A Phase 2 Study of Ruxolitinib With Chemotherapy in Children With Acute Lymphoblastic Leukemia

Phase 2

Active, not recruiting

Conditions: Leukemia

Interventions: Drug: Ruxolitinib
Drug: Asparaginase Erwinia Chrysanthemi
Drug: Cyclophosphamide
Drug: Cytarabine
Drug: Dexamethasone
Drug: Doxorubicin
Drug: Leucovorin Calcium
Drug: Mercaptopurine
Drug: Methotrexate
Drug: Pegaspargase
Drug: Prednisone
Drug: Thioguanine
Drug: Vincristine Sulfate

First Posted Date: 2016-03-31

Last Posted Date: 2024-11-29

Lead Sponsor: Incyte Corporation

Target Recruit Count: 171

Registration Number: NCT02723994

Locations: 🇺🇸
Sinai Hospital of Baltimore, Baltimore, Maryland, United States
🇺🇸
Childrens Hospital of Pittsburgh, Pittsburgh, Pennsylvania, United States
🇺🇸
Texas Childrens Hospital, Houston, Texas, United States

and more 105 locations

Sequential, Related Donor Partial Liver Transplantation Followed by Bone Marrow Transplantation for Hepatocellular Carcinoma (HCC)

Phase 2

Withdrawn

Conditions: Fibrolamellar Hepatocellular Carcinoma
Hepatocellular Carcinoma (Fibrolamellar Variant)
Hepatocellular Carcinoma

Interventions: Procedure: living related donor partial liver transplantation
Radiation: Total body irradiation
Procedure: Bone marrow transplant from same donor
Drug: Cyclophosphamide
Drug: Mesna
Drug: Filgrastim
Drug: Tacrolimus
Drug: mycophenolate mofetil
Drug: Prednisone
Drug: Antithymocyte globulin
Drug: fludarabine

First Posted Date: 2016-03-09

Last Posted Date: 2018-06-15

Lead Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Registration Number: NCT02702960

Locations: 🇺🇸
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, United States

Abiraterone Acetate, Prednisone, and Apalutamide With or Without Ipilimumab or Cabazitaxel and Carboplatin in Treating Patients With Metastatic Castration-Resistant Prostate Cancer

Phase 2

Active, not recruiting

Conditions: Castration-Resistant Prostate Carcinoma
Metastatic Prostate Carcinoma
Stage IV Prostate Adenocarcinoma AJCC v7
Castration Levels of Testosterone
PSA Progression

Interventions: Drug: Abiraterone Acetate
Drug: Apalutamide
Biological: Ipilimumab
Other: Laboratory Biomarker Analysis
Drug: Cabazitaxel
Drug: Carboplatin
Drug: Prednisone

First Posted Date: 2016-03-09

Last Posted Date: 2024-11-28

Lead Sponsor: M.D. Anderson Cancer Center

Target Recruit Count: 196

Registration Number: NCT02703623

Locations: 🇺🇸
MD Anderson in Katy, Houston, Texas, United States
🇺🇸
M D Anderson Cancer Center, Houston, Texas, United States
🇺🇸
MD Anderson in Sugar Land, Sugar Land, Texas, United States