Prednisone

Generic Name: Prednisone

Brand Names: Deltasone, Rayos, Winpred

Drug Type: Small Molecule

Chemical Formula: C_₂₁H_₂₆O_₅

CAS Number: 53-03-2

Unique Ingredient Identifier: VB0R961HZT

Background: A synthetic anti-inflammatory glucocorticoid derived from cortisone. It is biologically inert and converted to prednisolone in the liver.

Prednisone was granted FDA approval on 21 February 1955.

Indication: Prednisone is indicated as an anti-inflammatory or immunosuppressive drug for allergic, dermatologic, gastrointestinal, hematologic, ophthalmologic, nervous system, renal, respiratory, rheumatologic, infectious, endocrine, or neoplastic conditions as well as in organ transplant.

Associated Conditions: Acne Vulgaris, Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Acute Gouty Arthritis, Acute Leukemia, Aggressive Lymphoma, Allergic Bronchopulmonary Aspergillosis, Allergic Conjunctivitis (AC), Allergic Rhinitis (AR), Allergic corneal marginal ulcers, Alveolitis, Extrinsic Allergic, Ankylosing Spondylitis (AS), Aspiration Pneumonitis, Asthma, Atopic Dermatitis, Autoimmune Hepatitis, Bell's Palsy, Berylliosis, Bullous dermatitis herpetiformis, Chorioretinitis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Contact Dermatitis, Disseminated tuberculosis, Drug hypersensitivity reaction, Edema of the cerebrum, Epicondylitis, Erythroblastopenia, Giant Cell Arteritis (GCA), Hypercalcemia of Malignancy, Idiopathic Pulmonary Fibrosis (IPF), Immune Thrombocytopenia (ITP), Iridocyclitis, Iritis, Keratitis, Leukemias, Loeffler's syndrome, Lymphoma, Meningitis caused by Mycobacterium Tuberculosis, Metastatic Castration-Resistant Prostate Cancer (mCRPC), Mycosis Fungoides (MF), Ocular Inflammation, Ophthalmia, Sympathetic, Optic Neuritis, Pain caused by Herpes zoster, Pemphigus, Pericarditis, Pneumocystis Jirovecii Pneumonia, Polymyalgia Rheumatica (PMR), Polymyositis, Posterior Uveitis, Primary adrenocortical insufficiency, Psoriatic Arthritis, Pure Red Cell Aplasia, Regional Enteritis, Relapsing Polychondritis, Rheumatoid Arthritis, Rheumatoid Arthritis, Juvenile, Secondary adrenocortical insufficiency, Secondary thrombocytopenia, Serum Sickness, Severe Seborrheic Dermatitis, Sjogren's Syndrome (SS), Solid Organ Transplant Rejection, Stevens-Johnson Syndrome, Systemic Lupus Erythematosus, Takayasu Arteritis, Thyroid Eye Disease, Thyroiditis, Thyrotoxicosis, Trichinosis, Ulcerative Colitis, Uveitis, Vasculitis, Acquired immune hemolytic anemia, Acute Bursitis, Acute Crohn's Disease (CD), Acute Multiple sclerosis exacerbation, Acute rheumatic carditis, Anterior eye segment inflammation, Exfoliative erythroderma, Fulminating Tuberculosis, Idiopathic Bronchiolitis obliterans with organizing pneumonia, Idiopathic eosinophilic pneumonias, Non-suppurative Thyroiditis, Severe Psoriasis, Subacute Bursitis, Symptomatic Sarcoidosis, Synovitis of osteoarthritis, Systemic Dermatomyositis, Varicella-zoster virus acute retinal necrosis

Associated Therapies: Palliative Treatment

Clinical Trials

Pegaspargase and Combination Chemotherapy in Treating Younger Patients With Newly Diagnosed High-Risk Acute Lymphoblastic Leukemia (Closed to Accrual 4-22-2011)

Phase 1

Completed

Conditions: Acute Lymphoblastic Leukemia
Adult B Acute Lymphoblastic Leukemia
Childhood B Acute Lymphoblastic Leukemia

Interventions: Drug: Cyclophosphamide
Drug: Cytarabine
Drug: Daunorubicin Hydrochloride
Drug: Dexamethasone
Drug: Doxorubicin Hydrochloride
Other: Laboratory Biomarker Analysis
Drug: Mercaptopurine
Drug: Methotrexate
Drug: Pegaspargase
Drug: Thioguanine
Drug: Vincristine Sulfate
Drug: Prednisone
Radiation: Prophylactic Cranial Irradiation

First Posted Date: 2009-03-20

Last Posted Date: 2021-04-27

Lead Sponsor: Children's Oncology Group

Target Recruit Count: 104

Registration Number: NCT00866307

Locations: 🇺🇸
Children's Hospital Los Angeles, Los Angeles, California, United States
🇺🇸
Saint Vincent Hospital and Health Care Center, Indianapolis, Indiana, United States
🇺🇸
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston, Texas, United States

and more 25 locations

Asthma Exacerbation Study

Not Applicable

Withdrawn

Conditions: Asthma

First Posted Date: 2009-03-02

Last Posted Date: 2016-03-22

Lead Sponsor: University of Pittsburgh

Registration Number: NCT00853411

Treatment of High Risk Adult Acute Lymphoblastic Leukemia

Phase 4

Completed

Conditions: Acute Lymphoblastic Leukemia

First Posted Date: 2009-02-27

Last Posted Date: 2020-04-07

Lead Sponsor: PETHEMA Foundation

Target Recruit Count: 100

Registration Number: NCT00853008

Locations: 🇪🇸
Hospital Germans Trias i Pujol, Badalona, Spain
🇪🇸
Clínica Teknon, Barcelona, Spain
🇪🇸
Hospital de Fuenlabrada, Madrid, Spain

and more 30 locations

Treatment of Aggressive Localized Lymphoma

Phase 3

Terminated

Conditions: B Cell Lymphoma

Interventions: Drug: rituximab
Drug: doxorubicin
Drug: vincristine
Drug: prednisone
Procedure: radiotherapy

First Posted Date: 2009-02-12

Last Posted Date: 2017-02-23

Lead Sponsor: French Innovative Leukemia Organisation

Target Recruit Count: 334

Registration Number: NCT00841945

Locations: 🇫🇷
Regional university hospital, Rennes, France

Efficacy , Safety of Treatment R NIMP for Relapsed Aggressive Lymphomas

Phase 2

Completed

Conditions: Diffuse Large B-Cell Lymphoma

Interventions: Drug: rituximab
Drug: vinorelbine
Drug: ifosfamide
Drug: Mitoxantrone
Drug: Prednisone

First Posted Date: 2009-02-12

Last Posted Date: 2013-07-24

Lead Sponsor: French Innovative Leukemia Organisation

Target Recruit Count: 50

Registration Number: NCT00842595

Locations: 🇫🇷
Hôpital COCHIN, Paris, France

Chronic Rhinosinusitis With or Without Nasal Polyps Steroid Study

Phase 4

Withdrawn

Conditions: Rhinosinusitis
Nasal Polyps
Chronic Sinusitis

Interventions: Drug: Prednisone

First Posted Date: 2009-02-11

Last Posted Date: 2020-04-02

Lead Sponsor: Northwestern University

Registration Number: NCT00841802

Locations: 🇺🇸
Northwestern University, Chicago, Illinois, United States

Budesonide 3x3mg/d Versus Prednisone in Active Autoimmune Hepatitis

Phase 2

Completed

Conditions: Autoimmune Hepatitis

Interventions: Drug: budesonide
Drug: prednisone

First Posted Date: 2009-02-06

Last Posted Date: 2019-05-07

Lead Sponsor: Dr. Falk Pharma GmbH

Target Recruit Count: 208

Registration Number: NCT00838214

Locations: 🇩🇪
Medical School Hannover, Hannover, Niedersachsen, Germany

A Study of the Effects of Single Dose Corticosteroids on Response to Allergens

Phase 1

Completed

Conditions: Allergic Rhinitis

Interventions: Drug: Placebo
Drug: prednisone

First Posted Date: 2009-01-23

Last Posted Date: 2019-04-02

Lead Sponsor: Merck Sharp & Dohme LLC

Target Recruit Count: 19

Registration Number: NCT00828061

A Study of Obinutuzumab in Combination With Chemotherapy in Participants With CD20+ B-Cell Follicular Non-Hodgkin's Lymphoma

Phase 1

Completed

Conditions: Non-Hodgkin's Lymphoma

Interventions: Drug: Cyclophosphamide
Drug: Bendamustine
Drug: Doxorubicin
Drug: Fludarabine
Drug: Obinutuzumab
Drug: Prednisone
Drug: Vincristine

First Posted Date: 2009-01-19

Last Posted Date: 2016-11-04

Lead Sponsor: Hoffmann-La Roche

Target Recruit Count: 137

Registration Number: NCT00825149

S0816 Fludeoxyglucose F 18-PET/CT Imaging and Combination Chemotherapy With or Without Additional Chemotherapy and G-CSF in Treating Patients With Stage III or Stage IV Hodgkin Lymphoma

Phase 2

Completed

Conditions: Lymphoma
Nonneoplastic Condition

Interventions: Biological: bleomycin sulfate
Drug: BEACOPP regimen
Biological: filgrastim
Drug: ABVD regimen
Drug: cyclophosphamide
Drug: dacarbazine
Drug: doxorubicin hydrochloride
Drug: etoposide
Drug: vinblastine sulfate
Drug: prednisone
Drug: procarbazine hydrochloride
Drug: vincristine sulfate

First Posted Date: 2009-01-14

Last Posted Date: 2022-08-18

Lead Sponsor: SWOG Cancer Research Network

Target Recruit Count: 371

Registration Number: NCT00822120

Locations: 🇺🇸
Kaiser Foundation Hospital - San Rafael, San Rafael, California, United States
🇺🇸
Illinois CancerCare - Macomb, Macomb, Illinois, United States
🇺🇸
Saint Michael's Hospital Cancer Center, Stevens Point, Wisconsin, United States

and more 419 locations

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