Proparacaine
- Generic Name
- Proparacaine
- Brand Names
- Alcaine, Lenalidomide Krka d.d. Novo mesto (previously Lenalidomide Krka), Revlimid, Lenalidomide Mylan, Lenalidomide Krka (previously Lenalidomide Krka d.d. Novo mesto), Lenalidomide Accord
- Drug Type
- Small Molecule
- Chemical Formula
- C16H26N2O3
- CAS Number
- 499-67-2
- Unique Ingredient Identifier
- B4OB0JHI1X
- Background
Proparacaine is a topical anesthetic drug of the amino ester group. It is found in ophthalmic solutions at a concentration of 0.5% as the hydrochloride salt.
- Indication
Used as a local (ophthalmic) anesthetic.
- Associated Conditions
- Chronic Lymphocytic Leukemia (CLL) - Refractory, Follicular Lymphoma ( FL), Mantle Cell Lymphoma (MCL), Marginal Zone Lymphoma (MZL), Multiple Myeloma (MM), Myelodysplastic Syndrome, Primary Amyloidosis, Refractory Diffuse Large B Cell Lymphoma (DLBCL)
- Associated Therapies
- Local Anaesthesia therapy
Combination Therapy Using Lenalidomide (Revlimid)- Low Dose Dexamethasone and Rituximab for Treatment of Rituximab-Resistant, Non-Aggressive B-Cell Lymphomas
- First Posted Date
- 2008-10-31
- Last Posted Date
- 2023-03-30
- Lead Sponsor
- Abramson Cancer Center at Penn Medicine
- Target Recruit Count
- 50
- Registration Number
- NCT00783367
- Locations
- 🇺🇸
University of Pennsylvania; Abramson Cancer Center; Lymphoma Program, Philadelphia, Pennsylvania, United States
Pharmacokinetics of Lenalidomide (Revlimid®) in Patients With Multiple Myeloma and Impaired Renal Function
- First Posted Date
- 2008-10-24
- Last Posted Date
- 2016-10-11
- Lead Sponsor
- Poitiers University Hospital
- Target Recruit Count
- 39
- Registration Number
- NCT00779922
- Locations
- 🇫🇷
Poitiers University Hospital, Poitiers, France
A Study to Evaluate the Efficacy and Safety of Lenalidomide as Maintenance Therapy for Patients With B-Cell Chronic Lymphocytic Leukemia (CLL) Following Second Line Therapy
- Conditions
- Interventions
- First Posted Date
- 2008-10-17
- Last Posted Date
- 2021-12-02
- Lead Sponsor
- Celgene
- Target Recruit Count
- 317
- Registration Number
- NCT00774345
- Locations
- 🇺🇸
Pacific Coast Hematology Oncology, Fountain Valley, California, United States
🇺🇸Memorial Hospital, Hollywood, Florida, United States
🇺🇸The Cancer Center, Hackensack University Medical Center, Hackensack, New Jersey, United States
Lenalidomide With or Without Dexamethasone in Treating Patients With Newly Diagnosed Multiple Myeloma
- Conditions
- Interventions
- First Posted Date
- 2008-10-15
- Last Posted Date
- 2020-01-18
- Lead Sponsor
- Mayo Clinic
- Target Recruit Count
- 39
- Registration Number
- NCT00772915
- Locations
- 🇺🇸
Mayo Clinic, Rochester, Minnesota, United States
Lenalidomide With or Without Rituximab After Standard Chemotherapy in Treating Patients With Diffuse Large B-Cell Non-Hodgkin Lymphoma
- First Posted Date
- 2008-10-02
- Last Posted Date
- 2016-04-11
- Lead Sponsor
- Vanderbilt-Ingram Cancer Center
- Target Recruit Count
- 44
- Registration Number
- NCT00765245
- Locations
- 🇺🇸
Vanderbilt-Ingram Cancer Center - Cool Springs, Nashville, Tennessee, United States
🇺🇸Vanderbilt-Ingram Cancer Center at Franklin, Nashville, Tennessee, United States
🇺🇸Vanderbilt-Ingram Cancer Center, Nashville, Tennessee, United States
Lenalidomide in High-risk MDS and AML With Del(5q) or Monosomy 5
- First Posted Date
- 2008-09-29
- Last Posted Date
- 2012-04-27
- Lead Sponsor
- Nordic MDS Group
- Target Recruit Count
- 28
- Registration Number
- NCT00761449
- Locations
- 🇩🇰
Department of Hematology, Aalborg Hospital, Aalborg, Denmark
🇩🇰Department of Hematology, Herlev Hospital, Herlev, Denmark
🇩🇰Department of Hematology, Rigshospitalet, Copenhagen, Denmark
Lenalidomide and Rituximab as Treatment of Chronic Lymphocytic Leukemia
- Conditions
- Interventions
- First Posted Date
- 2008-09-25
- Last Posted Date
- 2015-08-27
- Lead Sponsor
- M.D. Anderson Cancer Center
- Target Recruit Count
- 60
- Registration Number
- NCT00759603
- Locations
- 🇺🇸
The University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States
Study of Lenalidomide in Previously Untreated, Symptomatic Chronic Lymphocytic Leukemia (CLL)
- First Posted Date
- 2008-09-11
- Last Posted Date
- 2016-06-16
- Lead Sponsor
- University Health Network, Toronto
- Target Recruit Count
- 27
- Registration Number
- NCT00751296
- Locations
- 🇨🇦
University Health Network - Princess Margaret Cancer Centre, Toronto, Ontario, Canada
A Phase 1b/2, Dose-Escalation Study of Elotuzumab (Humanized Anti-CS1 Monoclonal IgG1 Antibody) in Relapsed Multiple Myeloma
- Conditions
- Interventions
- First Posted Date
- 2008-08-27
- Last Posted Date
- 2018-01-10
- Lead Sponsor
- AbbVie (prior sponsor, Abbott)
- Target Recruit Count
- 101
- Registration Number
- NCT00742560
Lenalidomide Dose Escalation Combined With Rituximab/Fludarabine in Untreated CLL
- Conditions
- Interventions
- First Posted Date
- 2008-08-21
- Last Posted Date
- 2013-08-30
- Lead Sponsor
- Arbeitsgemeinschaft medikamentoese Tumortherapie
- Target Recruit Count
- 45
- Registration Number
- NCT00738829
- Locations
- 🇦🇹
Universitaetsklinik f. Innere Medizin III, Salzburg, Austria
🇦🇹Klinikum Wels-Grieskirchen GmbH, Wels, Austria
🇦🇹Medizinische Universitaet Innsbruck, Abtlg. f. Haematologie und Onkologie, Innsbruck, Tirol, Austria
Drug Development Updates
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