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Fecal microbiota is a bacterial suspension manufactured from human fecal matter used to prevent the recurrence of Clostridioides difficile infection.
Fecal microbiota is a bacterial suspension manufactured from human fecal matter used to prevent the recurrence of Clostridioides difficile infection.
The mechanism of action of fecal microbiota has not been established. In the prevention of the recurrence of Clostridioides difficile infection (CDI), it is possible that the reintroduction of normal flora from donors corrects the intestinal imbalance of microorganisms. Antibiotics, such as clindamycin, are used in the treatment of CDI; however, they can also lead to a chronic and contagious condition characterized by low phylotypic diversity, the presence of opportunistic pathogens, the upregulation of pro-inflammatory genes and the reduction of colon nutrients. The use of fecal microbiota transplantations increases the diversity of fecal microbiota as well as the proportion of "beneficial" bacteria.
Fecal microbiota is indicated for the prevention of recurrence of Clostridioides difficile infection (CDI) in individuals 18 years of age and older, following antibiotic treatment for recurrent CDI.
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