Carboxymethylcellulose

Generic Name: Carboxymethylcellulose

Brand Names: Leader Lubricant Eye Drops, Refresh Drops, Refresh Liquigel, Refresh Optive Advanced, Refresh Optive Extended Therapy, Retaine, Thera Tears, Theratears

Drug Type: Small Molecule

CAS Number: 9000-11-7

Unique Ingredient Identifier: 05JZI7B19X

Background: Carboxymethylcellulose is a cellulose derivative that consists of the cellulose backbone made up of glucopyranose monomers and their hydroxyl groups bound to carboxymethyl groups. It is added in food products as a viscosity modifier or thickener and emulsifier. It is also one of the most common viscous polymers used in artificial tears, and has shown to be effective in the treatment of aqueous tear-deficient dry eye symptoms and ocular surface staining . The viscous and mucoadhesive properties as well as its anionic charge allow prolonged retention time in the ocular surface . Sodium carboxymethylcellulose is the most commonly used salt.

Indication: Indicated for the symptomatic relief of burning, irritation and discomfort of the eyes due to dryness or exposure to wind or sun.

Associated Conditions: Dry Eyes, Ocular Irritation

Clinical Trials

Effects of Carboxymethylcellulose Artificial Tears on the Eye Microbiome

Phase 4

Completed

Conditions: Dry Eye Syndromes

Interventions: Drug: Preservative-free, CMC-free Artificial Tears (control)
Drug: Carboxymethylcellulose (CMC) Artificial Tears

First Posted Date: 2022-03-23

Last Posted Date: 2023-04-20

Lead Sponsor: University of Florida

Target Recruit Count: 80

Registration Number: NCT05292755

Locations: 🇺🇸
University of Florida Oaks Eye Center, Gainesville, Florida, United States

Effects of Stulln and Accommodative Training

Phase 1

Withdrawn

Conditions: Accommodation Disorder
Visual Fatigue

Interventions: Drug: Stulln Eyedrops
Drug: Thera Tears

First Posted Date: 2021-11-04

Last Posted Date: 2024-05-21

Lead Sponsor: Pacific University

Registration Number: NCT05107791

Locations: 🇺🇸
Vision Performance Institute, Forest Grove, Oregon, United States

Post Intravitreal Injection Topical NSAID vs. Patching

Phase 4

Conditions: Neovascular Age-related Macular Degeneration
Diabetic Macular Edema
Retinal Vein Occlusion

Interventions: Drug: Theratears tear drop, (Akron, Ann 111 Arbor, MI)
Other: patching
Drug: nepafenac 0.3% suspension (Ilevro; Alcon, Fort Worth, TX)

First Posted Date: 2019-04-17

Last Posted Date: 2019-04-17

Lead Sponsor: The New York Eye & Ear Infirmary

Target Recruit Count: 60

Registration Number: NCT03918590

Locations: 🇺🇸
New York Eye and Ear Infirmary, New York, New York, United States

Dry Eye Disease Study With Brimonidine

Phase 2

Completed

Conditions: Dry Eye

Interventions: Drug: Brimonidine Mono Therapy
Drug: sodium carboxymethylcellulose
Drug: Brimonidine
Drug: Corticosteroid Eye Drop

First Posted Date: 2018-02-01

Last Posted Date: 2022-07-06

Lead Sponsor: Ocugen

Target Recruit Count: 84

Registration Number: NCT03418727

Locations: 🇺🇸
Brenart Eye Clinic, Yorkville, Illinois, United States
🇺🇸
Chicago Cornea Consultants, Hoffman Estates, Illinois, United States
🇺🇸
The Eye Institute of Utah, Salt Lake City, Utah, United States

Efficacy and Safety of Iota-Carrageenan Eye Drops (NCX-4240)

Phase 2

Withdrawn

Conditions: Adenoviral Conjunctivitis

Interventions: Drug: Carmellose
Drug: Iota-Carrageenan

First Posted Date: 2017-01-04

Last Posted Date: 2017-05-10

Lead Sponsor: NicOx

Registration Number: NCT03009799

Locations: 🇪🇸
Hospital Clinico San Carlos, Madrid, Spain

Evaluation of Tear Osmolarity Over Time With Sustained Use of Thera Tears Lubricating Drops

Phase 4

Completed

Conditions: Dry Eye Syndrome

Interventions: Drug: TheraTears Lubricating Eye Drops

First Posted Date: 2016-05-02

Last Posted Date: 2017-08-18

Lead Sponsor: Koffler Vision Group

Target Recruit Count: 14

Registration Number: NCT02758327

A Safety and Efficacy Study of a New Eye Drop Formulation in Patients With Dry Eye Disease.

Phase 3

Completed

Conditions: Dry Eye Syndromes

Interventions: Drug: Carboxymethylcellulose Sodium 0.5%
Drug: Carboxymethylcellulose Based Eye Drop

First Posted Date: 2015-09-18

Last Posted Date: 2017-11-17

Lead Sponsor: Allergan

Target Recruit Count: 242

Registration Number: NCT02553772

Locations: 🇺🇸
Havana Research Institute LLC, Burbank, California, United States
🇦🇺
The University of New South Wales School of Optometry and Vision Science, Sydney, Australia
🇺🇸
Lugene Eye Institute, Glendale, California, United States

and more 10 locations