Diphenhydramine
- Generic Name
- Diphenhydramine
- Brand Names
- Acetadryl, Advil PM, Aleve PM, Allegra Cooling Relief Anti-itch, Banophen, Benadryl, Benadryl Itch Stopping, Benadryl-D Allergy and Sinus, Calagel, Damylin With Codeine, Dimetapp Nighttime Cold & Congestion, Diphen, Diphenhist, Diphenist, Excedrin PM Triple Action, Goody's PM, Legatrin PM, Motrin PM, Nytol, Nytol Quickgels, Percogesic Reformulated Jan 2011, Siladryl, Simply Sleep, Sleepinal, Sominex, Triaminic Night Time Cold & Cough, Tylenol PM, Unisom, Unisom Sleep, Vanamine, Wal-dryl, Wal-som (doxylamine), Zzzquil
- Drug Type
- Small Molecule
- Chemical Formula
- C17H21NO
- CAS Number
- 58-73-1
- Unique Ingredient Identifier
- 8GTS82S83M
- Background
Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes . However, it also has antiemetic, antitussive, hypnotic, and antiparkinson properties . As histamine receptors exist both ...
- Indication
Diphenhydramine is a first-generation histamine H1 receptor antagonist (H1 antihistamine) that is widely available as a non-prescription, over-the-counter (OTC) medication. As an OTC medication, diphenhydramine is typically formulated as tablets and creams indicated for use in treating sneezing, runny nose, itchy/watery eyes, itching of nose or throat, insom...
- Associated Conditions
- Allergic Reaction, Allergic Rhinitis (AR), Allergic cough, Allergy to Tree Pollen, Anaphylaxis, Angioedema, Common Cold, Conjunctival irritation, Cough, Cough Variant Asthma, Cough caused by Common Cold, Eye allergy, Fever, Insect Bites, Insect Stings, Insomnia, Irritative cough, Itching of the nose, Itching of the throat, Motion Sickness, Nasal Congestion, Oral Mucositis, Pain, Parkinsonian Syndromes, Productive cough, Pruritus, Rash, Rhinorrhoea, Sinus Congestion, Sinus headache, Skin Irritation, Sneezing, Sunburn, Symptoms of Acute Bronchitis Accompanied by Coughing, Upper respiratory tract hypersensitivity reaction, site unspecified, Urticaria, Cold or flu syndrome, Dermatographism, Dry cough, Watery itchy eyes
- Associated Therapies
- Airway secretion clearance therapy, Expectorant
Diphenhydramine as an Adjunctive Sedative in Patients on Chronic Opioids
- Conditions
- Interventions
- First Posted Date
- 2013-10-22
- Last Posted Date
- 2020-03-11
- Lead Sponsor
- University of Oklahoma
- Target Recruit Count
- 120
- Registration Number
- NCT01967433
- Locations
- 🇺🇸
Veterans Affairs Medical Center, Oklahoma City, Oklahoma, United States
First-time-in-man, to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of BP1.5375
- Conditions
- Interventions
- First Posted Date
- 2013-10-18
- Last Posted Date
- 2015-01-21
- Lead Sponsor
- Bioprojet
- Target Recruit Count
- 48
- Registration Number
- NCT01965301
- Locations
- 🇳🇱
Centre for Human Drug Research, Leiden, Netherlands
Intrathecal Levobupivacaine With Opioids for Caesarean Section
- First Posted Date
- 2013-05-21
- Last Posted Date
- 2013-05-21
- Lead Sponsor
- Baskent University
- Target Recruit Count
- 93
- Registration Number
- NCT01858090
- Locations
- 🇹🇷
Baskent University School of Medicine Adana Teaching and Research Hospital, Adana, Turkey
Morphine Mouthwash for Management of Oral Mucositis in Patients With Head and Neck Cancer
- Conditions
- Interventions
- First Posted Date
- 2013-04-23
- Last Posted Date
- 2013-04-23
- Lead Sponsor
- Isfahan University of Medical Sciences
- Target Recruit Count
- 30
- Registration Number
- NCT01837446
- Locations
- 🇮🇷
Radiation Oncology Department, Seyed Al-Shohada Hospital, Isfahan, Iran, Islamic Republic of
Diphenhydramine for Acute Migraine
- Conditions
- Interventions
- First Posted Date
- 2013-04-08
- Last Posted Date
- 2018-07-31
- Lead Sponsor
- Montefiore Medical Center
- Target Recruit Count
- 208
- Registration Number
- NCT01825941
- Locations
- 🇺🇸
Montefiore Medical Center, Bronx, New York, United States
Randomized Trial of Diphenhydramine Versus Continued Midazolam in "Difficult-to-sedate" Patients Undergoing Colonoscopy
- First Posted Date
- 2013-01-16
- Last Posted Date
- 2017-02-10
- Lead Sponsor
- VA Connecticut Healthcare System
- Target Recruit Count
- 200
- Registration Number
- NCT01769586
- Locations
- 🇺🇸
VA Connecticut Healthcare System, West Haven, Connecticut, United States
Effect of P-glycoprotein Inhibition on Lenalidomide Pharmacokinetics in Healthy Males
- Conditions
- Interventions
- First Posted Date
- 2012-10-24
- Last Posted Date
- 2019-11-08
- Lead Sponsor
- Celgene
- Target Recruit Count
- 31
- Registration Number
- NCT01712828
- Locations
- 🇺🇸
Covance Clinical Research Unit Dallas, Dallas, Texas, United States
The Role of Intravenous (IV) Lidocaine in the Management of Chronic Neuropathic Pain of Peripheral Nerve Origin
- First Posted Date
- 2012-08-21
- Last Posted Date
- 2019-03-15
- Lead Sponsor
- Lawson Health Research Institute
- Target Recruit Count
- 34
- Registration Number
- NCT01669967
- Locations
- 🇨🇦
St. Joseph's Health Care, London, Ontario, Canada
Compare Pharmacokinetic (PK) Profiles of Naproxen Sodium, Diphenhydramine Hydrochloride, and Naproxen Sodium and Diphenhydramine Hydrochloride Combination
- Conditions
- Interventions
- First Posted Date
- 2012-08-16
- Last Posted Date
- 2014-08-21
- Lead Sponsor
- Bayer
- Target Recruit Count
- 32
- Registration Number
- NCT01666678
TUSC2-nanoparticles and Erlotinib in Stage IV Lung Cancer
- Conditions
- Interventions
- First Posted Date
- 2011-10-20
- Last Posted Date
- 2022-03-02
- Lead Sponsor
- Genprex, Inc.
- Target Recruit Count
- 25
- Registration Number
- NCT01455389
- Locations
- 🇺🇸
UT MD Anderson Cancer Center, Houston, Texas, United States
Drug Development Updates
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