Citrulline
- Generic Name
- Citrulline
- Brand Names
- -
- Drug Type
- Small Molecule
- Chemical Formula
- C6H13N3O3
- CAS Number
- 372-75-8
- Unique Ingredient Identifier
- 29VT07BGDA
- Background
Citrulline is an amino acid. It is made from ornithine and carbamoyl phosphate in one of the central reactions in the urea cycle. It is also produced from arginine as a by-product of the reaction catalyzed by NOS family. Its name is derived from citrullus, the Latin word for watermelon, from which it was first isolated.
- Indication
Used for nutritional supplementation, also for treating dietary shortage or imbalance.
- Associated Conditions
- -
- Associated Therapies
- Nutritional supplementation
Intravenous L-Citrulline for Vaso-occlusive Pain Episode in Sickle Cell Disease
- Conditions
- Interventions
- First Posted Date
- 2024-10-10
- Last Posted Date
- 2024-10-10
- Lead Sponsor
- Suvankar Majumdar
- Target Recruit Count
- 99
- Registration Number
- NCT06635902
- Locations
- 🇺🇸
Children's National Hospital, Washington, District of Columbia, United States
Novel Approaches for Improving Vascular Function in Veterans With HFpEF
- First Posted Date
- 2024-03-15
- Last Posted Date
- 2024-03-21
- Lead Sponsor
- D. Walter Wray
- Target Recruit Count
- 90
- Registration Number
- NCT06312748
- Locations
- 🇺🇸
George E. Whalen VA Medical Center, Salt Lake City, Utah, United States
Oral Citrulline Supplementation in COPD Patients With Malnutrition
- Conditions
- Interventions
- First Posted Date
- 2024-01-19
- Last Posted Date
- 2024-01-19
- Lead Sponsor
- University Hospital, Grenoble
- Target Recruit Count
- 60
- Registration Number
- NCT06212765
Study to Improve Deployment Related Asthma by Using L-Citrulline Supplementation
- Conditions
- Interventions
- First Posted Date
- 2022-03-02
- Last Posted Date
- 2023-04-06
- Lead Sponsor
- University of Colorado, Denver
- Target Recruit Count
- 75
- Registration Number
- NCT05259904
- Locations
- 🇺🇸
National Jewish Health, Denver, Colorado, United States
A Study Evaluating the Efficacy and Safety of IV L-Citrulline for the Prevention of Clinical Sequelae of Acute Lung Injury Induced by Cardiopulmonary Bypass in Pediatric Patients Undergoing Surgery for Congenital Heart Defects
- Conditions
- Interventions
- First Posted Date
- 2022-02-23
- Last Posted Date
- 2023-08-21
- Lead Sponsor
- Asklepion Pharmaceuticals, LLC
- Target Recruit Count
- 97
- Registration Number
- NCT05253209
- Locations
- 🇺🇸
Children's of Alabama, Birmingham, Alabama, United States
🇺🇸Children's Hospital of Colorado, Aurora, Colorado, United States
🇺🇸Heart Center, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, United States
Role of L-citrulline in Prevention of Pregnancy Associated Hypertension
- Conditions
- Interventions
- First Posted Date
- 2021-07-28
- Last Posted Date
- 2024-10-28
- Target Recruit Count
- 338
- Registration Number
- NCT04979793
- Locations
- 🇺🇸
University of Texas Medical Branch, Galveston, Texas, United States
L-citrulline Injection in Patients Aged 6-21 Years Old With Sickle Cell Disease Presenting With Vaso-Occlusive Crisis (VOC)
- Conditions
- Interventions
- First Posted Date
- 2021-04-21
- Last Posted Date
- 2023-08-21
- Lead Sponsor
- Asklepion Pharmaceuticals, LLC
- Target Recruit Count
- 120
- Registration Number
- NCT04852172
- Locations
- 🇺🇸
Children's National Hospital, Washington DC, District of Columbia, United States
🇺🇸The University of Mississippi Medical Center, Jackson, Mississippi, United States
Intravenous L-Citrulline Influence on the Need for Invasive Mechanical Ventilation for Acute Hypoxemic Respiratory Failure in Patients With COVID-19
- Conditions
- Interventions
- First Posted Date
- 2020-09-30
- Last Posted Date
- 2023-02-22
- Lead Sponsor
- Asklepion Pharmaceuticals, LLC
- Target Recruit Count
- 65
- Registration Number
- NCT04570384
- Locations
- 🇺🇸
University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States
L-Citrulline Dose Finding Safety Study in MELAS
- First Posted Date
- 2019-05-16
- Last Posted Date
- 2024-06-26
- Lead Sponsor
- Baylor College of Medicine
- Target Recruit Count
- 10
- Registration Number
- NCT03952234
- Locations
- 🇺🇸
Baylor St. Luke'S Medical Center, Houston, Texas, United States
L-citrulline and Pulmonary Hypertension Associated With Bronchopulmonary Dysplasia
- Conditions
- Interventions
- First Posted Date
- 2018-05-31
- Last Posted Date
- 2024-06-10
- Lead Sponsor
- University of Utah
- Target Recruit Count
- 16
- Registration Number
- NCT03542812
- Locations
- 🇺🇸
University of Utah Health, Salt Lake City, Utah, United States
Drug Development Updates
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