Citrulline
- Generic Name
- Citrulline
- Brand Names
- -
- Drug Type
- Small Molecule
- Chemical Formula
- C6H13N3O3
- CAS Number
- 372-75-8
- Unique Ingredient Identifier
- 29VT07BGDA
- Background
Citrulline is an amino acid. It is made from ornithine and carbamoyl phosphate in one of the central reactions in the urea cycle. It is also produced from arginine as a by-product of the reaction catalyzed by NOS family. Its name is derived from citrullus, the Latin word for watermelon, from which it was first isolated.
- Indication
Used for nutritional supplementation, also for treating dietary shortage or imbalance.
- Associated Conditions
- -
- Associated Therapies
- Nutritional supplementation
L-citrulline for Prevention of Sequelae of Acute Lung Injury in Pediatrics Undergoing Cardiopulmonary Bypass for Heart Defects
- First Posted Date
- 2016-09-08
- Last Posted Date
- 2023-02-23
- Lead Sponsor
- Asklepion Pharmaceuticals, LLC
- Target Recruit Count
- 189
- Registration Number
- NCT02891837
- Locations
- 🇺🇸
The Johns Hopkins Hospital, Baltimore, Maryland, United States
🇺🇸Nicklaus Children's Hospital, Miami, Florida, United States
🇺🇸Seattle Children's Hospital, Seattle, Washington, United States
Evaluation of the Efficacy of Citrulline Supplementation on the Delay of Delivery for Women Hospitalized for Pre-eclampsia (CITRUPE)
- First Posted Date
- 2016-06-16
- Last Posted Date
- 2021-01-22
- Lead Sponsor
- Nantes University Hospital
- Target Recruit Count
- 116
- Registration Number
- NCT02801695
- Locations
- 🇫🇷
CHU de Nantes, Nantes, France
🇫🇷Hôpital Cochin (Maternité Port-Royal), Paris, France
Assessment of Short-term Effect of L-Citrulline on Endothelial Function and Vasodilation in Known CAD Patients
- First Posted Date
- 2015-12-23
- Last Posted Date
- 2015-12-23
- Lead Sponsor
- Shahid Beheshti University of Medical Sciences
- Target Recruit Count
- 30
- Registration Number
- NCT02638727
- Locations
- 🇮🇷
Shahid Modaress Hospital , Tehran, Iran, Tehran, Iran, Islamic Republic of
"Effects of Oral Citrulline on Protein Metabolism in Healthy Humans: a Prospective, Randomized, Double-blind , Cross-over Study" (Citrugrêle)
- First Posted Date
- 2008-09-19
- Last Posted Date
- 2010-03-09
- Lead Sponsor
- Nantes University Hospital
- Target Recruit Count
- 12
- Registration Number
- NCT00756080
- Locations
- 🇫🇷
CHU Nantes, Nantes, France
Oral L-Citrulline and ADMA in Pregnancy
- First Posted Date
- 2008-08-28
- Last Posted Date
- 2014-07-16
- Lead Sponsor
- University of Pittsburgh
- Target Recruit Count
- 41
- Registration Number
- NCT00743210
- Locations
- 🇺🇸
Magee-Womens Hospital of UPMC, Pittsburgh, Pennsylvania, United States
Intravenous L-Citrulline to Treat Children Undergoing Heart Bypass Surgery
- Conditions
- Interventions
- First Posted Date
- 2006-06-09
- Last Posted Date
- 2015-02-02
- Lead Sponsor
- Asklepion Pharmaceuticals, LLC
- Target Recruit Count
- 77
- Registration Number
- NCT00335244
- Locations
- 🇺🇸
Vanderbilt University Medical Center, Nashville, Tennessee, United States
Chemotherapy Toxicity Reduction Via Urea Cycle Support
- First Posted Date
- 2005-09-22
- Last Posted Date
- 2016-11-02
- Lead Sponsor
- Vanderbilt University
- Target Recruit Count
- 100
- Registration Number
- NCT00223730
- Locations
- 🇺🇸
Vanderbilt University Medical Center, Nashville, Tennessee, United States
Citrulline for Children Undergoing Cardiopulmonary Bypass Surgery
- Conditions
- First Posted Date
- 2005-09-20
- Last Posted Date
- 2013-09-12
- Lead Sponsor
- Vanderbilt University
- Target Recruit Count
- 26
- Registration Number
- NCT00201214
- Locations
- 🇺🇸
Vanderbilt University, Nashville, Tennessee, United States
Drug Development Updates
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