Tetracosactide

Generic Name
Tetracosactide
Brand Names
Cortrosyn, Synacthen
Drug Type
Small Molecule
Chemical Formula
C136H210N40O31S
CAS Number
16960-16-0
Unique Ingredient Identifier
72YY86EA29
Background

Tetracosactide (also known as Cosyntropin) is a synthetic peptide that is identical to the 24-amino acid segment (sequence: SYSMEHFRWGKPVGKKRRPVKVYP) at the N-terminal of adrenocorticotropic hormone. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of corticosteroids in the adrenal cortex. Tetracosact...

Indication

For use as a diagnostic agent in the screening of patients presumed to have adrenocortical insufficiency.

Associated Conditions
Acute Gouty Arthritis, Acute Rheumatic Fever, Adrenal Insufficiency, Ankylosing Spondylitis (AS), Bell's Palsy, Choroiditis, Conjunctivitis, Dermatomyositis (DM), Iritis, Keratitis, Lupus Erythematosus, Multiple sclerosis exacerbation, Nephrotic Syndrome, Ophthalmia, Sympathetic, Optic Neuritis, Panhypopituitarism, Pemphigus, Periarteritis nodosa, Psoriatic Arthritis, Rheumatoid Arthritis, Scleroderma, Still's Disease, Ulcerative Colitis, Uveitis, Acquired hemolytic jaundice, Exfoliative erythroderma
Associated Therapies
-
Clinical Trials
Related News

Defining the Mechanisms Underlying Adrenal Insufficiency in Cirrhosis

Completed
Conditions
Adrenal Insufficiency
Cirrhosis
Interventions
Drug: Cosyntropin
First Posted Date
2020-11-24
Last Posted Date
2024-12-10
Lead Sponsor
University of Virginia
Target Recruit Count
76
Registration Number
NCT04642391
Locations
🇺🇸

University of Virginia Health System, Charlottesville, Virginia, United States

Comparison of Intramuscular and Intravenous ACTH Stimulation Test in Normal Volunteers

Phase 4
Withdrawn
Conditions
Adrenal Insufficiency
Interventions
Drug: Cosyntropin
First Posted Date
2018-11-23
Last Posted Date
2019-05-10
Lead Sponsor
Johns Hopkins University
Registration Number
NCT03752190

Is Adrenal Insufficiency Under-diagnosed in Hospitalized Cirrhosis Patients?

First Posted Date
2017-12-11
Last Posted Date
2021-12-09
Lead Sponsor
University of Virginia
Target Recruit Count
100
Registration Number
NCT03368066
Locations
🇺🇸

University of Virginia Health System, Charlottesville, Virginia, United States

Cosyntropin Versus Epidural Blood Patch (EBP) for Treatment of Treatment of Post Dural Puncture Headache

First Posted Date
2015-03-20
Last Posted Date
2016-11-01
Lead Sponsor
United States Naval Medical Center, San Diego
Target Recruit Count
29
Registration Number
NCT02394457

Stress and the Nervous System

First Posted Date
2015-01-15
Last Posted Date
2022-07-25
Lead Sponsor
Brigham and Women's Hospital
Target Recruit Count
23
Registration Number
NCT02339506
Locations
🇺🇸

Brigham and Women's Hospital, Boston, Massachusetts, United States

Adrenal Responsiveness During the Perioperative Period in Children Undergoing Congenital Cardiac Surgery

Phase 1
Completed
Conditions
Adrenal Cortex Diseases
Infant Morbidity
Interventions
Drug: Cosyntropin
First Posted Date
2013-04-25
Last Posted Date
2014-06-16
Lead Sponsor
Mayo Clinic
Target Recruit Count
35
Registration Number
NCT01839812
Locations
🇺🇸

Mayo Clinic, Rochester, Minnesota, United States

Stress Biomarkers:Attaching Biological Meaning to Field Friendly Salivary Measures

First Posted Date
2012-08-27
Last Posted Date
2018-04-23
Lead Sponsor
University of Michigan
Target Recruit Count
256
Registration Number
NCT01673087
Locations
🇺🇸

University of Michigan Health System, Ann Arbor, Michigan, United States

Effect of Longer-term Adrenal Suppression Using Low Dose Hydrocortisone on Androgen Overproduction

First Posted Date
2011-08-24
Last Posted Date
2018-07-19
Lead Sponsor
University of Virginia
Registration Number
NCT01422733
Locations
🇺🇸

University of Virginia Center for Research in Reproduction, Charlottesville, Virginia, United States

Evaluation of Adrenal Androgens in Normal and Obese Girls After Suppression and Stimulation

Not Applicable
Active, not recruiting
Conditions
Obesity
Hyperandrogenemia
Polycystic Ovary Syndrome
Interventions
Drug: Dexamethasone
Drug: Cortrosyn
First Posted Date
2011-08-23
Last Posted Date
2023-10-27
Lead Sponsor
University of Virginia
Target Recruit Count
84
Registration Number
NCT01421797
Locations
🇺🇸

University of Virginia Center for Research in Reproduction, Charlottesville, Virginia, United States

Isolated ACTH Deficiency in Patients With Hashimoto Thyroiditis

Not Applicable
Completed
Conditions
Hashimoto Disease
Adrenal Insufficiency
Interventions
Drug: synacthen
First Posted Date
2007-11-02
Last Posted Date
2007-11-02
Lead Sponsor
University of Wuerzburg
Target Recruit Count
62
Registration Number
NCT00552487
Locations
🇩🇪

University of Wuerzburg, Department of Endocrinology, Wuerzburg, Bavaria, Germany

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