Metyrapone
- Generic Name
- Metyrapone
- Brand Names
- Metopirone
- Drug Type
- Small Molecule
- Chemical Formula
- C14H14N2O
- CAS Number
- 54-36-4
- Unique Ingredient Identifier
- ZS9KD92H6V
- Background
An inhibitor of the enzyme steroid 11-beta-monooxygenase. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of cushing syndrome.
- Indication
库欣综合征的鉴别诊断，也可用于治疗。也治疗某些肾上腺皮质肿瘤引起的肾上腺功能亢进。
Acute Consequences of Glucocorticoid Secretion in Overweight and Obese Individuals During Maximum Calorie Intake
- Conditions
- OvereatingGlucocorticoidsOverweight and Obesity
- Interventions
- Drug: Placebo
- First Posted Date
- 2024-08-16
- Last Posted Date
- 2025-04-16
- Lead Sponsor
- Eleonora Seelig
- Target Recruit Count
- 23
- Registration Number
- NCT06556277
- Locations
- 🇨🇭
University Hospital Basel, Basel, Basel-Stadt, Switzerland
Metyrapone for Mild Autonomous Cortisol Secretion (MACS)
- Conditions
- Autonomous Cortisol SecretionMild Autonomous Cortisol Secretion (MACS)
- Interventions
- First Posted Date
- 2023-10-30
- Last Posted Date
- 2024-08-26
- Lead Sponsor
- Mayo Clinic
- Target Recruit Count
- 30
- Registration Number
- NCT06106295
- Locations
- 🇺🇸
Mayo Clinic Minnesota, Rochester, Minnesota, United States
The Role of Glucocorticoids to Maintain Energy Homeostasis During Starvation (Gluco-Starve)
- Conditions
- Glucocorticoid Effect
- Interventions
- Drug: Placebo 250 mg TabletsDrug: Placebo (0,9% NaCl solution)
- First Posted Date
- 2023-06-27
- Last Posted Date
- 2024-08-14
- Lead Sponsor
- Eleonora Seelig
- Target Recruit Count
- 24
- Registration Number
- NCT05919992
- Locations
- 🇨🇭
University Hospital Basel, Basel, Basel-Stadt, Switzerland
Effects of Metyrapone in Patients With Hypercortisolism
- First Posted Date
- 2022-02-25
- Last Posted Date
- 2024-02-20
- Lead Sponsor
- Istituto Auxologico Italiano
- Target Recruit Count
- 20
- Registration Number
- NCT05255900
- Locations
- 🇮🇹
Istituto Auxologico Italiano, Milano, Italy
Acute Consequences Of Food-induced Glucocorticoid Secretion In Healthy Individuals
- Conditions
- Glucocorticoid Effect
- Interventions
- Drug: Placebo 250 mg TabletsDrug: Placebo (0,9% NaCl solution)
- First Posted Date
- 2021-12-22
- Last Posted Date
- 2023-08-23
- Lead Sponsor
- Eleonora Seelig
- Target Recruit Count
- 20
- Registration Number
- NCT05167084
- Locations
- 🇨🇭
University Hospital Basel, Basel, Basel-Stadt, Switzerland
Effects of the Addition of Metyrapone to Antidepressant Therapy in Depression With Dexamethasone Suppression Test Non-suppression.
- First Posted Date
- 2018-04-09
- Last Posted Date
- 2020-09-09
- Lead Sponsor
- Centre Hospitalier Rouffach
- Target Recruit Count
- 14
- Registration Number
- NCT03491696
- Locations
- 🇫🇷
Hopitaux Universitares de Strasbourg, Strasbourg, Bas Rhin, France
🇫🇷Centre Hospitalier de Rouffach, Rouffach, Haut Rhin, France
Single and Multiple Rising Dose Study of Safety and PK of Metyrapone/Oxazepam Combination (EMB-001)
- Conditions
- Tobacco Use DisorderCocaine Use Disorder
- Interventions
- Drug: Placebo
- First Posted Date
- 2015-04-02
- Last Posted Date
- 2016-07-22
- Lead Sponsor
- Embera NeuroTherapeutics, Inc.
- Target Recruit Count
- 24
- Registration Number
- NCT02406066
- Locations
- 🇺🇸
Collaborative Neuroscience Network, LLC, Long Beach, California, United States
🇺🇸Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States
Effects of Metyrapone in Patients With Endogenous Cushing's Syndrome
- First Posted Date
- 2014-11-21
- Last Posted Date
- 2020-09-25
- Lead Sponsor
- HRA Pharma
- Target Recruit Count
- 50
- Registration Number
- NCT02297945
- Locations
- 🇧🇪
CHU Erasme, Brussels, Belgium
🇷🇴Spitalul Universitar de Urgenta Militar Central 'Dr Carol Davila', Bucharest, Romania
🇷🇴Spitalul Clinic Judetean de Urgenta Sibiu, Sibiu, Romania
Stress Biomarkers:Attaching Biological Meaning to Field Friendly Salivary Measures
- Conditions
- Stress
- Interventions
- First Posted Date
- 2012-08-27
- Last Posted Date
- 2018-04-23
- Lead Sponsor
- University of Michigan
- Target Recruit Count
- 256
- Registration Number
- NCT01673087
- Locations
- 🇺🇸
University of Michigan Health System, Ann Arbor, Michigan, United States
Cortisol and Nutritional Sympathetic Responsiveness
- Conditions
- Insulin ResistanceMetabolic SyndromeObesity
- Interventions
- Drug: placebo
- First Posted Date
- 2012-06-15
- Last Posted Date
- 2014-09-09
- Lead Sponsor
- Baker Heart Research Institute
- Target Recruit Count
- 24
- Registration Number
- NCT01620684
- Locations
- 🇦🇺
Heart Centre, Alfred Hospital, Prahran, Melbourne, Victoria, Australia
Drug Development Updates
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