D-Serine

Generic Name
D-Serine
Brand Names
-
Drug Type
Small Molecule
Chemical Formula
C3H7NO3
CAS Number
312-84-5
Unique Ingredient Identifier
1K77H2Z9B1
Background

A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids. [PubChem]

Associated Conditions
-
Associated Therapies
-

D-serine AudRem: R33 Phase

First Posted Date
2021-09-16
Last Posted Date
2024-01-09
Lead Sponsor
New York State Psychiatric Institute
Target Recruit Count
60
Registration Number
NCT05046353
Locations
🇺🇸

NYSPI, New York, New York, United States

A Study to Compare the Safety, Tolerability, and Pharmacokinetics of CTP-692 Versus D-serine in Healthy Volunteers

Phase 1
Completed
Conditions
Interventions
First Posted Date
2018-12-19
Last Posted Date
2019-03-15
Lead Sponsor
Concert Pharmaceuticals
Target Recruit Count
13
Registration Number
NCT03778320
Locations
🇦🇺

CMAX Clinical Research, Adelaide, South Australia, Australia

D-serine Augmentation of Neuroplasticity

First Posted Date
2018-10-18
Last Posted Date
2022-06-14
Lead Sponsor
New York State Psychiatric Institute
Target Recruit Count
45
Registration Number
NCT03711500
Locations
🇺🇸

New York State Psychiatric Institute, New York, New York, United States

🇺🇸

Nathan Kline Institute, Orangeburg, New York, United States

D-serine and Cognitive Remediation in Schizophrenia

Phase 2
Completed
Conditions
Interventions
First Posted Date
2014-06-05
Last Posted Date
2020-10-08
Lead Sponsor
Nathan Kline Institute for Psychiatric Research
Target Recruit Count
8
Registration Number
NCT02156908
Locations
🇺🇸

Nathan Kline Institute, Orangeburg, New York, United States

D-Serine for Cocaine Dependence Pilot

First Posted Date
2012-10-26
Last Posted Date
2014-02-06
Lead Sponsor
Theresa Winhusen
Registration Number
NCT01715051
Locations
🇺🇸

Maryhaven, Inc, Columbus, Ohio, United States

N-methyl-D-aspartic Acid (NMDA) and Cognitive Remediation in Schizophrenia

First Posted Date
2011-11-18
Last Posted Date
2012-10-25
Lead Sponsor
Nathan Kline Institute for Psychiatric Research
Target Recruit Count
16
Registration Number
NCT01474395
Locations
🇺🇸

Nathan Kline Insitute for Psychiatric Research, Orangeburg, New York, United States

High Dose D-Serine as Adjuvant Treatment for Recent Onset Schizophrenia

Phase 2
Conditions
Interventions
First Posted Date
2011-10-25
Last Posted Date
2011-10-25
Lead Sponsor
Hadassah Medical Organization
Target Recruit Count
54
Registration Number
NCT01459029
Locations
🇮🇱

Ezrath Nashim - Herzog Memorial Hospital & Community Clinics, Jerusalem, Israel

🇮🇱

Hadassah Medical Organization, Jerusalem, Israel

Developing New Treatments for Tourette Syndrome: Therapeutic Trials With Modulators of Glutamatergic Neurotransmission

Phase 4
Completed
Conditions
Interventions
First Posted Date
2009-11-23
Last Posted Date
2018-01-30
Lead Sponsor
Johns Hopkins University
Target Recruit Count
39
Registration Number
NCT01018056
Locations
🇺🇸

Johns Hopkins University, Baltimore, Maryland, United States

D-serine for the Schizophrenia Prodrome

Phase 2
Completed
Conditions
Interventions
First Posted Date
2009-01-22
Last Posted Date
2017-08-14
Lead Sponsor
Nathan Kline Institute for Psychiatric Research
Target Recruit Count
44
Registration Number
NCT00826202
Locations
🇺🇸

Yale University, New Haven, Connecticut, United States

🇺🇸

Zucker Hillside Hospital, Glen Oaks, New York, United States

🇺🇸

New York State Psychiatric Institute, New York, New York, United States

and more 1 locations

D-serine Monotherapy for Schizophrenia

Phase 2
Completed
Conditions
Interventions
First Posted Date
2009-01-05
Last Posted Date
2013-12-10
Lead Sponsor
Herzog Hospital
Target Recruit Count
18
Registration Number
NCT00816894
Locations
🇮🇱

Ezrath Nashim - Herzog Memorial Hospital, Jerusalem, Israel

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