Desmoteplase
- Generic Name
- Desmoteplase
- Brand Names
- -
- Drug Type
- Biotech
- Chemical Formula
- -
- CAS Number
- 145137-38-8
- Unique Ingredient Identifier
- T36L245S3T
- Background
Desmoteplase is a chemical in the saliva of vampire bats. It activates plasminogen to the serine protease, plasmin. Plasmin acts by breaking down fibrin blood clots. When a vampire bat bites its victim, it secretes an enzyme that prevents the blood from clotting. The enzyme is called DSPA (Desmodus rotundus salivary plasminogen activator) and scientists are ...
- Indication
Investigated for use/treatment in cerebral ischemia and strokes.
- Associated Conditions
- -
- Associated Therapies
- -
Clinical Study of Desmoteplase in Japanese Patients With Acute Ischemic Stroke
- First Posted Date
- 2010-04-15
- Last Posted Date
- 2021-08-31
- Lead Sponsor
- Lundbeck Japan K. K.
- Target Recruit Count
- 48
- Registration Number
- NCT01104467
- Locations
- 🇯🇵
JP024, Kagoshima, Japan
🇯🇵JP011, Kawasaki, Japan
🇯🇵JP004, Sendai, Japan
Efficacy and Safety Study of Desmoteplase to Treat Acute Ischemic Stroke (DIAS-4)
- First Posted Date
- 2009-03-06
- Last Posted Date
- 2017-03-16
- Lead Sponsor
- H. Lundbeck A/S
- Target Recruit Count
- 270
- Registration Number
- NCT00856661
- Locations
- 🇺🇸
US077, Lebanon, New Hampshire, United States
🇺🇸US064, Shreveport, Louisiana, United States
🇺🇸US063, Fairfield, Connecticut, United States
Efficacy and Safety Study of Desmoteplase to Treat Acute Ischemic Stroke
- First Posted Date
- 2008-11-14
- Last Posted Date
- 2015-09-18
- Lead Sponsor
- H. Lundbeck A/S
- Target Recruit Count
- 492
- Registration Number
- NCT00790920
- Locations
- 🇦🇺
AU006, Clayton, Australia
🇫🇷FR012, Limoges, France
🇮🇳IN008, Hyderabad, India
Desmoteplase in Acute Ischemic Stroke (DIAS)
- First Posted Date
- 2008-03-19
- Last Posted Date
- 2008-03-19
- Lead Sponsor
- PAION Deutschland GmbH
- Target Recruit Count
- 104
- Registration Number
- NCT00638781
- Locations
- 🇩🇪
Prof. Dr. Werner Hacke, Heidelberg, Germany
Dose Escalation of Desmoteplase in Acute Ischemic Stroke (DEDAS)
- First Posted Date
- 2008-03-19
- Last Posted Date
- 2008-03-19
- Lead Sponsor
- PAION Deutschland GmbH
- Target Recruit Count
- 38
- Registration Number
- NCT00638248
Study of Desmoteplase (International Nonproprietary Name [INN]) in Acute Ischemic Stroke (DIAS-2)
- First Posted Date
- 2005-05-27
- Last Posted Date
- 2012-03-20
- Lead Sponsor
- Forest Laboratories
- Target Recruit Count
- 193
- Registration Number
- NCT00111852
- Locations
- 🇨🇦
Vancouver General Hospital, Vancouver, British Columbia, Canada
🇺🇸Melbourne Internal Medicine Associates (MIMA), Melbourne, Florida, United States
🇺🇸The Methodist Hospital, Houston, Texas, United States
Drug Development Updates
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