Olesoxime
- Generic Name
- Olesoxime
- Brand Names
- -
- Drug Type
- Small Molecule
- Chemical Formula
- C27H45NO
- CAS Number
- 22033-87-0
- Unique Ingredient Identifier
- 8V8EF6094N
- Background
Olesoxime is a cholesterol-like small molecule that has demonstrated a remarkable neuroprotective profile in a battery of both in vitro and in vivo preclinical models. For example, it has demonstrated the ability to prevent neurodegeneration, enhance nerve function and accelerate neuroregeneration following nerve trauma.
- Indication
Investigated for use/treatment in neurologic disorders.
- Associated Conditions
- -
- Associated Therapies
- -
A Study of the Excretion Balance of Radiocarbon and the Pharmacokinetics and Metabolic Profile of TRO19622 (Olesoxime)
- First Posted Date
- 2016-07-18
- Last Posted Date
- 2016-07-18
- Lead Sponsor
- Hoffmann-La Roche
- Target Recruit Count
- 6
- Registration Number
- NCT02835976
A Study to Evaluate Long Term Safety, Tolerability, and Effectiveness of Olesoxime in Patients With Spinal Muscular Atrophy (SMA)
- First Posted Date
- 2015-12-11
- Last Posted Date
- 2019-08-09
- Lead Sponsor
- Hoffmann-La Roche
- Target Recruit Count
- 131
- Registration Number
- NCT02628743
- Locations
- 🇫🇷
Hopital Femme Mere Enfant; Medecine Physique et Readaptation Pediatrique - L'ESCALE, Bron, France
🇫🇷Hôpital Raymond Poincare; Serv. Neurologie et Réanimation pédiatriques - Centre réf. neuromusculaire, Garches, France
🇫🇷Hopital Jeanne De Flandre; CIC pediatrique, Lille, France
Safety and Efficacy of Olesoxime (TRO19622) in 3-25 Years SMA Patients.
- Conditions
- Interventions
- First Posted Date
- 2011-02-24
- Last Posted Date
- 2016-11-22
- Lead Sponsor
- Hoffmann-La Roche
- Target Recruit Count
- 165
- Registration Number
- NCT01302600
- Locations
- 🇫🇷
Hôpital Raymond Poincaré, Garches, France
🇫🇷Hôpital Femme-Mère-Enfant, Bron, France
🇩🇪University of Essen, Essen, Germany
Safety and Efficacy of TRO19622 as add-on Therapy to Riluzole Versus Placebo in Treatment of Patients Suffering From ALS
- Conditions
- Interventions
- First Posted Date
- 2009-03-24
- Last Posted Date
- 2020-02-25
- Lead Sponsor
- Hoffmann-La Roche
- Target Recruit Count
- 512
- Registration Number
- NCT00868166
- Locations
- 🇧🇪
University Hospital Gasthuisberg - Dept Neurology - Herestraat 49, Leuven, Belgium
🇫🇷Hôpital La Timone - Service Neurologie et Maladies Neuromusculaires, Marseille, France
🇫🇷Clinique du Motoneurone - Sce d'Explorations Neurologiques - Hôpital Gui de Chauliac, Montpellier, France
Drug Development Updates
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