Cangrelor

Generic Name
Cangrelor
Brand Names
Kengreal, Kengrexal
Drug Type
Small Molecule
Chemical Formula
C17H25Cl2F3N5O12P3S2
CAS Number
163706-06-7
Unique Ingredient Identifier
6AQ1Y404U7
Background

Cangrelor is an intravenous, direct-acting, reversible P2Y12 inhibitor for patients undergoing percutaneous coronary intervention (PCI) who have not been yet treated by oral P2Y12 inhibitors. An advantage Cangrelor provides over oral P2Y12 inhibitors (such as prasugrel, ticagrelor, and clopidogrel) is that it is an active drug not requiring metabolic conversion therefore providing a rapid onset and offset of action. Cangrelor was approved by the FDA in June 2015 for intravenous application.

Indication

For use as an adjunct to percutaneous coronary intervention (PCI) for reducing the risk of periprocedural myocardial infarction (MI), repeat coronary revascularization, and stent thrombosis (ST) in patients in who have not been treated with a P2Y12 platelet inhibitor and are not being given a glycoprotein IIb/IIIa inhibitor.

Associated Conditions
Coronary Revascularization, Peri-procedural Myocardial Infarction, Thrombosis (Stent Thrombosis)
Associated Therapies
-

Assess the Effect of Cangrelor at the Therapeutic Dose and a Supratherapeutic Dose Level on the QT/QTc Interval in Healthy Volunteers

Phase 1
Completed
Conditions
Interventions
First Posted Date
2008-06-18
Last Posted Date
2012-01-18
Lead Sponsor
The Medicines Company
Target Recruit Count
67
Registration Number
NCT00699504
Locations
🇺🇸

Charles River Clinical Services NW, Tacoma, Washington, United States

Cangrelor Versus Standard Therapy to Achieve Optimal Management of Platelet Inhibition.

First Posted Date
2006-10-06
Last Posted Date
2014-05-05
Lead Sponsor
The Medicines Company
Target Recruit Count
5364
Registration Number
NCT00385138
Locations
🇺🇸

Innovis Health, Fargo, North Dakota, United States

Pharmacokinetics/Pharmacodynamics (PK/PD) of Cangrelor

Phase 1
Completed
Conditions
First Posted Date
2005-02-01
Last Posted Date
2011-08-16
Lead Sponsor
The Medicines Company
Target Recruit Count
40
Registration Number
NCT00102674
Locations
🇺🇸

University of Kentucky, Lexington, Kentucky, United States

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