Overview
Nitrogen is a chemical element with symbol N and atomic number 7. At room temperature, it is a transparent, odorless diatomic gas. Liquid nitrogen is used principally in cryotherapy for removal of diseased skin. Liquid nitrogen helps in removal of skin lesions through necrosis, which results from the freezing and thawing of cells. Cryotherapy usually done in doctors' office. Also, nitrogen is very famous component in fertilizers and energy-stores.
Background
Nitrogen is a chemical element with symbol N and atomic number 7. At room temperature, it is a transparent, odorless diatomic gas. Liquid nitrogen is used principally in cryotherapy for removal of diseased skin. Liquid nitrogen helps in removal of skin lesions through necrosis, which results from the freezing and thawing of cells. Cryotherapy usually done in doctors' office. Also, nitrogen is very famous component in fertilizers and energy-stores.
Indication
Liquid nitrogen is used mainly as a cryogenic agent for the treatment of various benign and malignant skin lesions.
Associated Conditions
- Actinic Keratosis (AK)
- Benign skin lesions
- Hypoxemia
- Verruca (Warts)
Clinical Trials
Title | Posted | Study ID | Phase | Status | Sponsor |
|---|---|---|---|---|---|
2023/10/18 | Phase 4 | Recruiting | Copenhagen University Hospital at Herlev | ||
2023/06/08 | Phase 1 | Completed | Combined Military Hospital Abbottabad | ||
2023/02/22 | Phase 1 | Completed | Combined Military Hospital Abbottabad | ||
2022/02/25 | Phase 3 | Completed | |||
2020/08/27 | Early Phase 1 | Withdrawn | James Reynolds | ||
2020/05/21 | Phase 2 | Withdrawn | Roger Alvarez | ||
2020/05/07 | Phase 2 | Terminated | |||
2019/07/16 | Phase 2 | Recruiting | |||
2019/06/20 | Phase 4 | Terminated | |||
2019/02/01 | Phase 2 | Recruiting |
FDA Drug Approvals
Approved Product | Manufacturer | NDC Code | Route | Strength | Effective Date |
|---|---|---|---|---|---|
| PURITY CYLINDER GASES INC | 10927-101 | RESPIRATORY (INHALATION) | 99 L in 100 L | 10/31/2018 | |
| Welding & Therapy Service Inc. | 33344-002 | RESPIRATORY (INHALATION) | 99 L in 100 L | 7/22/2011 | |
| A OX Welding Supply Company Inc. | 10297-200 | RESPIRATORY (INHALATION) | 990 mL in 1 L | 10/17/2023 | |
| Airtec Gases, LLC | 24312-002 | RESPIRATORY (INHALATION) | 99 L in 100 L | 10/6/2023 | |
| NLR Welding Supply, Inc. | 62045-6333 | RESPIRATORY (INHALATION) | 99 L in 100 L | 2/9/2018 | |
| Messer LLC | 52438-016 | RESPIRATORY (INHALATION) | 995 mL in 1 L | 10/5/2023 | |
| J & M CYLINDER GASES, INC. | 63862-002 | RESPIRATORY (INHALATION) | 99.5 L in 1 L | 12/21/2018 | |
| Roberts Oxygen Company, Inc | 46123-003 | RESPIRATORY (INHALATION) | 990 mL in 1 L | 11/16/2023 | |
| Haun Specialty Gases, Inc. | 14961-003 | RESPIRATORY (INHALATION) | 990 L in 1 L | 10/3/2018 | |
| Schwarcz Liquid Nitrogen Service, Inc. | 42392-001 | RESPIRATORY (INHALATION) | 1 L in 1 L | 2/1/2012 |
EMA Drug Approvals
Approved Product | Authorization Holder | Status | Issued Date |
|---|---|---|---|
| No EMA approvals found for this drug. | |||
HSA Drug Approvals
Approved Product | Manufacturer | Approval Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No HSA approvals found for this drug. | |||||
NMPA Drug Approvals
Approved Product | Company | Approval Number | Drug Type | Dosage Form | Approval Date |
|---|---|---|---|---|---|
| No NMPA approvals found for this drug. | |||||
PPB Drug Approvals
Approved Product | Registration No. | Company | Licence No. | Strength | Registration Date |
|---|---|---|---|---|---|
| No PPB approvals found for this drug. | |||||
TGA Drug Approvals
Approved Product | ARTG ID | Sponsor | Registration Type | Status | Registration Date |
|---|---|---|---|---|---|
| MEDICAL SPECIAL GAS MIXTURES | 34465 | Medicine | A | 1/2/1992 | |
| AIR LIQUIDE AUSTRALIA LIMITED Nitrogen 100% v/v refrigerated liquid | 32750 | Medicine | A | 11/1/1991 | |
| REFRIGERATED LIQUID NITROGEN | 34462 | Medicine | A | 1/2/1992 |