Opicapone
- Generic Name
- Opicapone
- Brand Names
- Ongentys, Ontilyv
- Drug Type
- Small Molecule
- Chemical Formula
- C15H10Cl2N4O6
- CAS Number
- 923287-50-7
- Unique Ingredient Identifier
- Y5929UIJ5N
- Background
Opicapone is a potent, reversible, and peripherally-acting third-generation inhibitor of catechol-o-methyltransferase (COMT), an enzyme involved in the breakdown of various catecholamines including dopamine. Many patients with Parkinson’s disease treated with levodopa plus a dopa decarboxylase (DDC) inhibitor (eg carbidopa) experience motor complications ove...
- Indication
Opicapone is indicated as adjunctive therapy in adults with Parkinson’s disease and end-of-dose motor fluctuations or “off” episodes whose symptoms cannot be stabilized on the combination therapy of levodopa and DOPA decarboxylase inhibitor (e.g., carbidopa).
- Associated Conditions
- Parkinson's Disease (PD)
- Associated Therapies
- -
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