Methylprednisolone hemisuccinate

Generic Name: Methylprednisolone hemisuccinate

Brand Names: Solu-medrol

Drug Type: Small Molecule

Chemical Formula: C_₂₆H_₃₄O_₈

CAS Number: 2921-57-5

Unique Ingredient Identifier: 5GMR90S4KN

Background: A water-soluble ester of methylprednisolone used for cardiac, allergic, and hypoxic emergencies.

Associated Conditions: Acute Gouty Arthritis, Ankylosing Spondylitis (AS), Berylliosis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Dermatitis bullous, Dermatomyositis (DM), Edema of the cerebrum, Hypercalcemia of Malignancy, Immune Thrombocytopenia (ITP), Leukemias, Lymphoma, Multiple sclerosis exacerbation, Mycosis Fungoides (MF), Ophthalmia, Sympathetic, Pemphigus, Polymyositis, Primary adrenocortical insufficiency, Psoriatic Arthritis, Pure Red Cell Aplasia, Refractory Uveitis, Regional Enteritis, Rheumatoid Arthritis, Secondary adrenocortical insufficiency, Secondary thrombocytopenia, Stevens-Johnson Syndrome, Systemic Lupus Erythematosus, Temporal Arteritis, Trichinosis, Tuberculous Meningitis, Ulcerative Colitis, Acquired immune hemolytic anemia, Acute rheumatic carditis, Disseminated Pulmonary Tuberculosis (TB), Exfoliative erythroderma, Fulminating Pulmonary Tuberculosis, Idiopathic eosinophilic pneumonias, Non-suppurative Thyroiditis, Severe Allergic Reactions, Symptomatic Sarcoidosis

Associated Therapies: Palliative Treatment

Clinical Trials

RCT on the Efficacy of Dexamethasone Versus Methyl Prednisolone in Covid-19 Infected Patients With High Oxygen Flow

Phase 4

Conditions: COVID-19 Pandemic

Interventions: Drug: Dexamethasone
Drug: Methylprednisolone

First Posted Date: 2021-09-30

Last Posted Date: 2021-09-30

Lead Sponsor: Cairo University

Target Recruit Count: 60

Registration Number: NCT05062681

Locations: 🇪🇬
Eman Osama, Cairo, Egypt

A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Obinutuzumab in Adolescents With Active Class III or IV Lupus Nephritis and the Safety and PK of Obinutuzumab in Pediatric Participants

Phase 2

Recruiting

Conditions: Lupus Nephritis

Interventions: Drug: Placebo
Drug: Obinutuzumab
Drug: Mycophenolate Mofetil
Drug: Acetaminophen/paracetamol
Drug: Diphenhydramine hydrochloride (HCl)
Drug: Methylprednisolone
Drug: Prednisone

First Posted Date: 2021-09-09

Last Posted Date: 2024-12-02

Lead Sponsor: Hoffmann-La Roche

Target Recruit Count: 40

Registration Number: NCT05039619

Locations: 🇪🇸
Hospital Ramon y Cajal ; Servicio de Reumatologia, Madrid, Spain
🇺🇸
University of California San Francisco, San Francisco, California, United States
🇧🇷
Universidade Federal de Sao Paulo - UNIFES, Sao Paulo, SP, Brazil

and more 38 locations

TNFα Monoclonal Antibody for Acute Spinal Cord Injury

Phase 1

Conditions: Spinal Cord Injuries

Interventions: Drug: Saline
Drug: TNFα Monoclonal Antibody
Drug: Methylprednisolone

First Posted Date: 2021-08-03

Last Posted Date: 2022-05-09

Lead Sponsor: Shanghai Changzheng Hospital

Target Recruit Count: 90

Registration Number: NCT04988425

Locations: 🇨🇳
Shanghai Changzheng Hospital, Shanghai, China

Corticosteroid Effects on Asymptomatic Gadolinium-enhancing Lesions in Multiple Sclerosis

Phase 2

Conditions: Magnetic Resonance Imaging
Multiple Sclerosis, Relapsing-Remitting
Methylprednisolone

Interventions: Drug: Methylprednisolone succinate
Drug: Normal saline

First Posted Date: 2021-07-28

Last Posted Date: 2021-08-05

Lead Sponsor: Mazandaran University of Medical Sciences

Target Recruit Count: 104

Registration Number: NCT04979650

Locations: 🇮🇷
Mazandaran University of medical sciences, Sari, Mazandaran, Iran, Islamic Republic of

A Study to Evaluate the Efficacy and Safety of Obinutuzumab in Participants With Systemic Lupus Erythematosus

Phase 3

Active, not recruiting

Conditions: Systemic Lupus Erythematosus

Interventions: Drug: Placebo
Drug: Obinutuzumab
Drug: Acetaminophen/Paracetamol
Drug: Diphenhydramine hydrochloride
Drug: Methylprednisolone

First Posted Date: 2021-07-15

Last Posted Date: 2024-10-16

Lead Sponsor: Hoffmann-La Roche

Target Recruit Count: 300

Registration Number: NCT04963296

Locations: 🇺🇸
Pinnacle Research Group; Llc, Central, Anniston, Alabama, United States
🇺🇸
Unity Health - White County Medical Center- Rheumatology, Searcy, Arkansas, United States
🇺🇸
Providence Medical Foundation, Fullerton, California, United States

and more 80 locations

Sirolimus vs Corticosteroids in Treatment of Thyroid Eye Disease

Phase 2

Recruiting

Conditions: Thyroid-Associated Ophthalmopathy

Interventions: Drug: Sirolimus 1 mg Oral Tablet
Drug: Methylprednisolone

First Posted Date: 2021-06-23

Last Posted Date: 2023-03-06

Lead Sponsor: Haukeland University Hospital

Target Recruit Count: 60

Registration Number: NCT04936854

Locations: 🇳🇴
Department of Ophthalmology Haukeland University Hospital, Bergen, Hordaland, Norway

Factors Influencing the Prognosis of Olfactory Dysfunction After Upper Sensation

Phase 2

Not yet recruiting

Conditions: Outcome

Interventions: Drug: budesonide atomization suspension
Drug: methylprednisolone

First Posted Date: 2021-06-09

Last Posted Date: 2021-06-09

Lead Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University

Target Recruit Count: 90

Registration Number: NCT04918953

Locations: 🇨🇳
Department of Otolaryngology, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China

Elotuzumab in Immunoglobulin G4-Related Disease (IgG4-RD)

Phase 2

Terminated

Conditions: IgG4 Related Disease
IgG4-RD

Interventions: Drug: placebo for elotuzumab
Drug: elotuzumab
Drug: methylprednisolone
Drug: diphenhydramine
Drug: acetaminophen
Drug: famotidine
Drug: prednisone

First Posted Date: 2021-06-08

Last Posted Date: 2024-01-11

Lead Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Target Recruit Count: 8

Registration Number: NCT04918147

Locations: 🇺🇸
Massachusetts General Hospital, Boston, Massachusetts, United States
🇺🇸
Mayo Clinic: Pulmonary and Critical Care Medicine, Rochester, Minnesota, United States
🇺🇸
Emory Healthcare, Atlanta, Georgia, United States