DaxibotulinumtoxinA

Generic Name: DaxibotulinumtoxinA

Brand Names: Botox, Botox Cosmetic, Daxxify, Dysport, Xeomin

Drug Type: Biotech

Chemical Formula: -

CAS Number: 93384-43-1

Unique Ingredient Identifier: E211KPY694

Background: DaxibotulinumtoxinA is an acetylcholine release inhibitor and neuromuscular blocking agent. It is a botulinum toxin without accessory proteins purified from the bacterium Clostridium botulinum type A, the gram-positive anaerobic bacterium primarily present in soil. C. botulinum is known to produce toxins that can cause botulism in humans.
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Indication: DaxibotulinumtoxinA is indicated for the temporary improvement in the appearance of moderate to severe glabellar lines associated with corrugator and/or procerus muscle activity in adult patients. It is also used for the treatment of cervical dystonia in adult patients.

Associated Conditions: Cervical Dystonia, Moderate Glabellar Frown Lines (GL), Severe Glabellar Frown Lines (GL)

Associated Therapies: -

Clinical Trials

Are Paraspinous Intramuscular Injections of Botulinum Toxin A (BoNT-A) Efficient in the Treatment of Chronic Low-back Pain (LBP)?

Phase 3

Completed

Conditions: Chronic Low-back Pain

Interventions: Drug: Placebos
Drug: Botox

First Posted Date: 2017-06-09

Last Posted Date: 2017-06-09

Lead Sponsor: University Hospital, Bordeaux

Target Recruit Count: 19

Registration Number: NCT03181802

Locations: 🇫🇷
Bordeaux University Hospital, Bordeaux, France

Comparison of the Treatment of Refractory Bladder Pain Syndrome With DMSO and DMSO With Botulinum Toxin A

Early Phase 1

Completed

Conditions: Bladder Pain Syndrome

Interventions: Drug: DMSO
Drug: Botox

First Posted Date: 2017-04-06

Last Posted Date: 2017-06-09

Lead Sponsor: University of Pennsylvania

Target Recruit Count: 2

Registration Number: NCT03103594

The Impact of Botulinum Toxin on Brow Height and Morphology: A Randomized Controlled Trial

Phase 4

Conditions: Brow Lifting

Interventions: Drug: Dysport
Procedure: lateral orbicularis injection
Procedure: Lateral orbicularis + corrugator injection

First Posted Date: 2016-10-24

Last Posted Date: 2017-05-15

Lead Sponsor: St Joseph University, Beirut, Lebanon

Target Recruit Count: 30

Registration Number: NCT02942303

Locations: 🇱🇧
Hotel Dieu De France, Beirut, Aschrafieh, Lebanon

Itch Relieving Effect of Botox: a Study in Healthy Subjects

Phase 1

Completed

Conditions: Pruritus

Interventions: Drug: Saline
Drug: Botox

First Posted Date: 2015-12-24

Last Posted Date: 2017-04-27

Lead Sponsor: Temple University

Target Recruit Count: 35

Registration Number: NCT02639052

Does Botulinum Toxin A Make Walking Easier in Children With Cerebral Palsy?

Phase 4

Completed

Conditions: Cerebral Palsy
Muscle Spasticity

Interventions: Drug: botox
Drug: placebo

First Posted Date: 2015-09-11

Last Posted Date: 2022-01-11

Lead Sponsor: St. Olavs Hospital

Target Recruit Count: 61

Registration Number: NCT02546999

Locations: 🇳🇴
University Hospital of North-Norway, Tromsø, Norway
🇵🇱
Mazowieckie Centrum Neuropsychiatrii, Zagorze, Warsaw, Poland
🇳🇴
Vestfold Hospital trust, Tønsberg, Norway

and more 4 locations

Botox for Neurogenic Detrusor Overactivity and the Prevention of Autonomic Dysreflexia Following SCI

Phase 4

Completed

Conditions: Autonomic Dysreflexia

Interventions: Drug: BOTOX

First Posted Date: 2014-11-24

Last Posted Date: 2019-12-26

Lead Sponsor: Rick Hansen Institute

Target Recruit Count: 55

Registration Number: NCT02298660

Locations: 🇨🇦
International Collaboration on Repair Discoveries (ICORD), Vancouver, British Columbia, Canada

Randomized Control Trial of the Use of Botox to Treat Chronic Scrotal Pain

Phase 2

Completed

Conditions: Scrotal Pain

Interventions: Drug: Placebo
Drug: Botox

First Posted Date: 2014-09-25

Last Posted Date: 2019-03-11

Lead Sponsor: Mount Sinai Hospital, Canada

Target Recruit Count: 64

Registration Number: NCT02249234

Locations: 🇨🇦
Mount Sinai Hospital, Toronto, Ontario, Canada

Treatment With Xeomin Versus Botox in Children With Spastic Equine and Equinovarus Foot Deformation in Pediatric Cerebral Palsy

Phase 2

Completed

Conditions: Spastic Paraplegia and Hemiparesis
Equine and Equinovarus Foot Deformation
Cerebral Palsy

Interventions: Drug: Botox®
Drug: Xeomin

First Posted Date: 2014-07-11

Last Posted Date: 2017-01-26

Lead Sponsor: Merz Pharmaceuticals GmbH

Target Recruit Count: 64

Registration Number: NCT02188277

Locations: 🇷🇺
Federal State Budget Educational Institution of Higher Professional Learning "Stavropol State Medical University" of the Ministry of Health of the Russian Federation, Stavropol, Russian Federation
🇷🇺
Federal State Autonomous Institution "Scientific Center of Children's Health" of the Ministry of Health of the Russian Federation, Moscow, Russian Federation
🇷🇺
State Budget Institution of Health in Moscow "Scientific and Practical Center of Pediatric psychoneurology Moscow Health Department", Moscow, Russian Federation