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Zinc

Generic Name
Zinc
Brand Names
Vitafol-one, Wilzin
Drug Type
Small Molecule
Chemical Formula
Zn
CAS Number
7440-66-6
Unique Ingredient Identifier
J41CSQ7QDS
Background

A metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with anemia, short stature, hypogonadism, impaired wound healing, and geophagia. It is identified by the symbol Zn .

A newer study suggests implies that an imbalance of zinc is associated with the neuronal damage associated with traumatic brain injury, stroke, and seizures .

Understanding the mechanisms that control brain zinc homeostasis is, therefore, imperative to the development of preventive and treatment regimens for these and other neurological disorders .

In addition to the above, recent review articles have already demonstrated the important role of zinc in the pathophysiology and treatment of affective disorders, plus discussed the potential value of zinc as a marker of these diseases . Most recently, research has shown that polymorphism of the common polymorphism in zinc transporter SLC30A8/ZnT8 may increase susceptibility to type 2 diabetes provided novel insights into the role of zinc in diabetes .

Indication

Zinc can be used for the treatment and prevention of zinc deficiency/its consequences, including stunted growth and acute diarrhea in children, and slowed wound healing. It is also utilized for boosting the immune system, treating the common cold and recurrent ear infections, as well as preventing lower respiratory tract infections .

Associated Conditions
Candidiasis, Common Cold, Diaper Dermatitis, Diaper Rash, Eye redness, Iron Deficiency (ID), Ocular Irritation, Skin Irritation, Sunburn, Wilson's Disease, Zinc Deficiency
Associated Therapies
Dietary and Nutritional Therapies, Dietary supplementation

Correction of Zinc Deficiency in Children With Chronic Kidney Disease and Kidney Transplant

Phase 3
Completed
Conditions
Trace Element Excess
Zinc Deficiency
Renal Insufficiency, Chronic
Trace Element Deficiency
Interventions
Procedure: Repeat blood and urine tests
First Posted Date
2014-04-30
Last Posted Date
2017-03-13
Lead Sponsor
Hamilton Health Sciences Corporation
Target Recruit Count
40
Registration Number
NCT02126293
Locations
šŸ‡ØšŸ‡¦

Children's Hospital, London Health Science Centre University of Western Ontario, London, Ontario, Canada

šŸ‡ØšŸ‡¦

McMaster Children's Hospital, Hamilton, Ontario, Canada

Comparison of Ferrous Sulfate, Polymaltose Complex and Iron-zinc in Iron Deficiency Anemia

Not Applicable
Completed
Conditions
Iron Deficiency Anemia
Interventions
Drug: SantaferĀ® sp.
Drug: Ferro SanolĀ® sp
First Posted Date
2014-03-04
Last Posted Date
2014-03-04
Lead Sponsor
Hacettepe University
Target Recruit Count
60
Registration Number
NCT02076828
Locations
šŸ‡¹šŸ‡·

Hacettepe University, Ankara, Ankara/Sihhiye, Turkey

Testing the Effect of Zinc Supplementation to Improve the Treatment Effect of Botulinum Toxin for Oculofacial Spasm

Not Applicable
Conditions
Blepharospasm
Hemifacial Spasm
Interventions
Drug: Sugar pill
First Posted Date
2012-03-07
Last Posted Date
2012-03-07
Lead Sponsor
St. Joseph's Healthcare Hamilton
Target Recruit Count
40
Registration Number
NCT01546805
Locations
šŸ‡ØšŸ‡¦

St Joseph's Hospital Hamilton, Hamilton, Ontario, Canada

šŸ‡ØšŸ‡¦

Carrot Eye Centre, Mississauga, Ontario, Canada

A RTC to Examine the Effectiveness of 400 mg of Oral Zinc Gluconate as Adjunctive Therapy for Ano-genital Warts

Phase 4
Terminated
Conditions
Genital Warts
HPV
Interventions
Drug: Placebo
First Posted Date
2011-11-09
Last Posted Date
2016-11-02
Lead Sponsor
University of British Columbia
Target Recruit Count
50
Registration Number
NCT01468636
Locations
šŸ‡ØšŸ‡¦

BC Centre for Disease Control, Vancouver, British Columbia, Canada

Zinc Supplementation and Severe and Recurrent Diarrhea

Not Applicable
Completed
Conditions
Diarrhea
Interventions
First Posted Date
2011-03-01
Last Posted Date
2011-03-01
Lead Sponsor
Hormozgan University of Medical Sciences
Target Recruit Count
100
Registration Number
NCT01306097
Locations
šŸ‡®šŸ‡·

Hormozgan University of medical sciences, Bandar Abbas, Hormozgan, Iran, Islamic Republic of

Safety Study of High Doses of Zinc in ALS Patients

Phase 1
Completed
Conditions
Amyotrophic Lateral Sclerosis
Interventions
First Posted Date
2010-12-13
Last Posted Date
2012-03-12
Lead Sponsor
Phoenix Neurological Associates, LTD
Target Recruit Count
10
Registration Number
NCT01259050
Locations
šŸ‡ŗšŸ‡ø

Phoenix Neurological Associates, Phoenix, Arizona, United States

Systemic Zinc Sulphate in Treatment of Recurrent Aphthous Ulcerations:A Doubleblind, Placebo Controled Study

Phase 2
Completed
Conditions
Aphthous Stomatitis
Interventions
First Posted Date
2010-09-28
Last Posted Date
2010-09-28
Lead Sponsor
Qazvin University Of Medical Sciences
Target Recruit Count
14
Registration Number
NCT01210014
Locations
šŸ‡®šŸ‡·

Qazvin university of medical sciences, Qazvin, Iran, Islamic Republic of

Effect of Zinc Suplementation on Serum Hemosystein Level in Hemodialysis Patients

Not Applicable
Completed
Conditions
End Stage Renal Failure
Interventions
First Posted Date
2010-04-09
Last Posted Date
2010-04-09
Lead Sponsor
Shiraz University of Medical Sciences
Target Recruit Count
100
Registration Number
NCT01101217
Locations
šŸ‡®šŸ‡·

Shiraz University Hemodialysis Center, Shiraz,, Fars, Iran, Islamic Republic of

Micronutrient Supplementation in in Paediatric Pulmonary Tuberculosis

Phase 3
Completed
Conditions
Tuberculosis
Interventions
Drug: Micronutrient without zinc
Drug: Placebo
Drug: Micronutrient with zinc
First Posted Date
2008-12-03
Last Posted Date
2016-02-10
Lead Sponsor
All India Institute of Medical Sciences, New Delhi
Target Recruit Count
403
Registration Number
NCT00801606
Locations
šŸ‡®šŸ‡³

Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, Delhi, India

Zinc to Treat Tinnitus in the Elderly

Phase 2
Completed
Conditions
Tinnitus
Interventions
Drug: Placebo oral capsule
First Posted Date
2008-05-23
Last Posted Date
2017-12-13
Lead Sponsor
University of Iowa
Target Recruit Count
116
Registration Number
NCT00683644
Locations
šŸ‡ŗšŸ‡ø

University of Iowa, Iowa City, Iowa, United States

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