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Zinc

Generic Name
Zinc
Brand Names
Vitafol-one, Wilzin
Drug Type
Small Molecule
Chemical Formula
Zn
CAS Number
7440-66-6
Unique Ingredient Identifier
J41CSQ7QDS
Background

A metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with anemia, short stature, hypogonadism, impaired wound healing, and geophagia. It is identified by the symbol Zn .

A newer study suggests implies that an imbalance of zinc is associated with the neuronal damage associated with traumatic brain injury, stroke, and seizures .

Understanding the mechanisms that control brain zinc homeostasis is, therefore, imperative to the development of preventive and treatment regimens for these and other neurological disorders .

In addition to the above, recent review articles have already demonstrated the important role of zinc in the pathophysiology and treatment of affective disorders, plus discussed the potential value of zinc as a marker of these diseases . Most recently, research has shown that polymorphism of the common polymorphism in zinc transporter SLC30A8/ZnT8 may increase susceptibility to type 2 diabetes provided novel insights into the role of zinc in diabetes .

Indication

Zinc can be used for the treatment and prevention of zinc deficiency/its consequences, including stunted growth and acute diarrhea in children, and slowed wound healing. It is also utilized for boosting the immune system, treating the common cold and recurrent ear infections, as well as preventing lower respiratory tract infections .

Associated Conditions
Candidiasis, Common Cold, Diaper Dermatitis, Diaper Rash, Eye redness, Iron Deficiency (ID), Ocular Irritation, Skin Irritation, Sunburn, Wilson's Disease, Zinc Deficiency
Associated Therapies
Dietary and Nutritional Therapies, Dietary supplementation

Effect of Zinc Supplementation on Hyperhomocysteinemia Compared to Folic Acid in CKD Patient on Hemodialysis

Not Applicable
Active, not recruiting
Conditions
Chronic Kidney Disease Requiring Hemodialysis
Interventions
Drug: Folic Acid 5 Mg Oral Tablet
First Posted Date
2025-02-26
Last Posted Date
2025-05-04
Lead Sponsor
Chittagong Medical College
Target Recruit Count
90
Registration Number
NCT06847139
Locations
๐Ÿ‡ง๐Ÿ‡ฉ

Chittagong Medical College, Chittagong, Bangladesh

Impact of Zinc As a New Adjuvant Therapy for Cow Milk Protein Allergy in Children.

Not Applicable
Conditions
Cow Milk Protein Allergy
Interventions
First Posted Date
2024-11-04
Last Posted Date
2025-03-06
Lead Sponsor
Kasr El Aini Hospital
Target Recruit Count
190
Registration Number
NCT06673082
Locations
๐Ÿ‡ช๐Ÿ‡ฌ

faculty of medicine-Cairo universty, Giza, Egypt

The Effect of Probiotic and Zinc Supplementation in Patients With Gastroesophageal Reflux Disease

Phase 4
Not yet recruiting
Conditions
Gastro-oesophageal Reflux Disease
Interventions
Drug: PPI (proton pump inhibitor)
First Posted Date
2024-10-29
Last Posted Date
2024-10-29
Lead Sponsor
Ain Shams University
Target Recruit Count
120
Registration Number
NCT06664008

Zinc and Nicotinamide Riboside for Idiopathic Pulmonary Fibrosis

Phase 2
Not yet recruiting
Conditions
Idiopathic Pulmonary Fibrosis
Interventions
Other: Placebos for zinc and nicotinamide riboside
First Posted Date
2024-08-23
Last Posted Date
2024-08-23
Lead Sponsor
Cedars-Sinai Medical Center
Target Recruit Count
60
Registration Number
NCT06567717
Locations
๐Ÿ‡บ๐Ÿ‡ธ

Cedars-Sinai, Los Angeles, California, United States

Comparison of Effectiveness of Zinc Supplementation With ORS and Bacillus Clausii Versus Zinc With ORS and Saccharomyces Boulardii in Acute Watery Diarrhea in Paediatric Patients

Not Applicable
Completed
Conditions
Acute Watery Diarrhea
Interventions
First Posted Date
2024-08-06
Last Posted Date
2024-08-12
Lead Sponsor
RESnTEC, Institute of Research
Target Recruit Count
60
Registration Number
NCT06540209
Locations
๐Ÿ‡ต๐Ÿ‡ฐ

University of Child Health Sciences, The Children's Hospital, Lahore, Punjab, Pakistan

The Clinical Investigation of Colgate Dual Zinc Toothpaste as Compared to Colgate Cavity Protection Toothpaste in Controlling Established Plaque and Gingivitis

Phase 3
Not yet recruiting
Conditions
Plaque, Dental
Gingivitis
Interventions
Drug: MFP Fluoride toothpaste
First Posted Date
2024-05-28
Last Posted Date
2024-06-14
Lead Sponsor
Colgate Palmolive
Target Recruit Count
90
Registration Number
NCT06430060
Locations
๐Ÿ‡จ๐Ÿ‡ณ

West China Dental Institute of Chengdu, Chengdu, Sichuan, China

Efficacy and Safety of 30% Supramolecular Salicylic Acid Combined With Supramolecular Active Zinc in the Treatment of Malassezia Folliculitis

Phase 4
Completed
Conditions
Malassezia Folliculitis
Interventions
Drug: 30% supramolecular salicylic acid
First Posted Date
2024-03-12
Last Posted Date
2024-03-12
Lead Sponsor
Second Affiliated Hospital of Xi'an Jiaotong University
Target Recruit Count
21
Registration Number
NCT06307223
Locations
๐Ÿ‡จ๐Ÿ‡ณ

The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China

The Effect of Platelet-rich Plasma Nasal Injection in the Treatment of Traumatic Olfactory Dysfunction

Phase 3
Not yet recruiting
Conditions
Traumatic Olfactory Nerve Injury With Anosmia (Diagnosis)
Effect of Drug
Interventions
Combination Product: platelet-rich plasma combined with hyaluronic acid
Device: 4 bottles of phenyl ethyl alcohol, lemon, eucalyptus, and clove oil
First Posted Date
2024-03-04
Last Posted Date
2024-03-04
Lead Sponsor
Taichung Veterans General Hospital
Target Recruit Count
80
Registration Number
NCT06290219
Locations
๐Ÿ‡จ๐Ÿ‡ณ

Taichung Veterans General Hospital, Taichung, Taiwan

Zinc Supplementation in Sickle Cell Disease: A Precursor to the Think Zinc for Bones Trial

Phase 2
Not yet recruiting
Conditions
Sickle Cell Disease
Interventions
First Posted Date
2024-02-15
Last Posted Date
2024-11-07
Lead Sponsor
University of California, San Francisco
Target Recruit Count
34
Registration Number
NCT06260891
Locations
๐Ÿ‡บ๐Ÿ‡ธ

UCSF Benioff Children's Hospital Oakland, Oakland, California, United States

Effect of Probiotic and Zinc Supplementations on the Clinical Outcome in Pediatric Patients with Ventriculitis

Phase 4
Recruiting
Conditions
Ventriculitis, Infectious
Interventions
Drug: Probiotic Formula
First Posted Date
2023-11-30
Last Posted Date
2025-02-25
Lead Sponsor
Ain Shams University
Target Recruit Count
140
Registration Number
NCT06151392
Locations
๐Ÿ‡ช๐Ÿ‡ฌ

Ain shams university, Cairo, Egypt

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