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Zinc

Generic Name
Zinc
Brand Names
Vitafol-one, Wilzin
Drug Type
Small Molecule
Chemical Formula
Zn
CAS Number
7440-66-6
Unique Ingredient Identifier
J41CSQ7QDS
Background

A metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with anemia, short stature, hypogonadism, impaired wound healing, and geophagia. It is identified by the symbol Zn .

A newer study suggests implies that an imbalance of zinc is associated with the neuronal damage associated with traumatic brain injury, stroke, and seizures .

Understanding the mechanisms that control brain zinc homeostasis is, therefore, imperative to the development of preventive and treatment regimens for these and other neurological disorders .

In addition to the above, recent review articles have already demonstrated the important role of zinc in the pathophysiology and treatment of affective disorders, plus discussed the potential value of zinc as a marker of these diseases . Most recently, research has shown that polymorphism of the common polymorphism in zinc transporter SLC30A8/ZnT8 may increase susceptibility to type 2 diabetes provided novel insights into the role of zinc in diabetes .

Indication

Zinc can be used for the treatment and prevention of zinc deficiency/its consequences, including stunted growth and acute diarrhea in children, and slowed wound healing. It is also utilized for boosting the immune system, treating the common cold and recurrent ear infections, as well as preventing lower respiratory tract infections .

Associated Conditions
Candidiasis, Common Cold, Diaper Dermatitis, Diaper Rash, Eye redness, Iron Deficiency (ID), Ocular Irritation, Skin Irritation, Sunburn, Wilson's Disease, Zinc Deficiency
Associated Therapies
Dietary and Nutritional Therapies, Dietary supplementation

Effect of Pentoxifylline and Zinc Co-administration in Patients With Oligoasthenoteratozoospermia

Not Applicable
Conditions
Idiopathic Infertility
Interventions
First Posted Date
2021-12-14
Last Posted Date
2022-01-03
Lead Sponsor
Arak University of Medical Sciences
Target Recruit Count
140
Registration Number
NCT05156684

EmoLED Medical Device Treatment of Second and Third Stage Pressure Ulcers

Not Applicable
Completed
Conditions
Pressure Sore
Pressure Ulcer
Pressure Ulcers Stage III
Pressure Ulcers Stage II
Interventions
Procedure: cleansing
Device: blue light photobiomodulation
Combination Product: hyaluronic acid gauze plus polyurethane foam
Procedure: topical treatment
Procedure: bandage
First Posted Date
2021-11-23
Last Posted Date
2025-01-28
Lead Sponsor
Emoled
Target Recruit Count
48
Registration Number
NCT05130814
Locations
🇮🇹

IRCCS Don Carlo Gnocchi, Firenze, Italy

Zinc Supplementation and Nutrition Education Among Children in the Rural Community

Phase 2
Completed
Conditions
Effects of; Serum
Interventions
Behavioral: Nutrition education of mothers
First Posted Date
2020-10-05
Last Posted Date
2020-10-06
Lead Sponsor
University of Douala
Target Recruit Count
150
Registration Number
NCT04574544

Efficacy of Subcutaneous Ivermectin With or Without Zinc in COVID-19 Patients

Phase 1
Conditions
COVID
Sars-CoV2
Coronavirus Infection
Interventions
Other: Injectable Placebo
Drug: Placebo empty capsule
First Posted Date
2020-07-15
Last Posted Date
2021-02-17
Lead Sponsor
Sohaib Ashraf
Target Recruit Count
180
Registration Number
NCT04472585
Locations
🇵🇰

Ali Clinic, Lahore, MA, Pakistan

🇵🇰

Shaikh Zayed Hospital, Lahore, Punjab, Pakistan

The Study of Quadruple Therapy Zinc, Quercetin, Bromelain and Vitamin C on the Clinical Outcomes of Patients Infected With COVID-19

Phase 4
Conditions
Covid-19
Interventions
Dietary Supplement: bromelain
First Posted Date
2020-07-13
Last Posted Date
2020-07-13
Lead Sponsor
Ministry of Health, Saudi Arabia
Target Recruit Count
60
Registration Number
NCT04468139
Locations
🇸🇦

Ministry of health.First health cluster ,Riaydh, Riyadh, Saudi Arabia

Zinc With Chloroquine/Hydroxychloroquine in Treatment of COVID-19

Phase 3
Completed
Conditions
COVID
Interventions
First Posted Date
2020-06-25
Last Posted Date
2022-04-01
Lead Sponsor
Tanta University
Target Recruit Count
191
Registration Number
NCT04447534
Locations
🇪🇬

Tanta university hospital, Assuit University, Ainshams University, Tanta, Egypt

A Preventive Treatment for Migrant Workers at High-risk of COVID-19

Phase 3
Completed
Conditions
Covid-19
Interventions
First Posted Date
2020-06-24
Last Posted Date
2020-10-19
Lead Sponsor
National University Hospital, Singapore
Target Recruit Count
4257
Registration Number
NCT04446104
Locations
🇸🇬

Tuas South Dormitory, Singapore, Singapore

A Study of Hydroxychloroquine and Zinc in the Prevention of COVID-19 Infection in Military Healthcare Workers

First Posted Date
2020-05-06
Last Posted Date
2020-05-06
Lead Sponsor
Military Hospital of Tunis
Target Recruit Count
660
Registration Number
NCT04377646
Locations
🇹🇳

Military Hospital of Tunis, Tunis, Tunisia

Impact of the Use of Zinc in the Prevention of Oral Mucositis in Pediatric Patients With Lymphoblastic Acute Leukemia.

Not Applicable
Terminated
Conditions
Oral Mucositis
Interventions
Drug: Placebo oral tablet
First Posted Date
2020-03-25
Last Posted Date
2020-08-04
Lead Sponsor
National Institute of Pediatrics, Mexico
Target Recruit Count
21
Registration Number
NCT04321850
Locations
🇲🇽

Marta M. Zapta Tarrés, Mexico, Mexico

Effect of Oral Zinc Supplementation as an Adjuvant to Topical Corticosteroid in Oral Lichen Planus Patients

Phase 4
Conditions
Oral Lichen Planus
Interventions
Drug: Oral placebo supplementation
First Posted Date
2020-02-20
Last Posted Date
2020-07-21
Lead Sponsor
Postgraduate Institute of Dental Sciences Rohtak
Target Recruit Count
42
Registration Number
NCT04278599
Locations
🇮🇳

Post Graduate Institute of Dental Sciences, Rohtak, Haryana, India

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