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Zinc

Generic Name
Zinc
Brand Names
Vitafol-one, Wilzin
Drug Type
Small Molecule
Chemical Formula
Zn
CAS Number
7440-66-6
Unique Ingredient Identifier
J41CSQ7QDS
Background

A metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with anemia, short stature, hypogonadism, impaired wound healing, and geophagia. It is identified by the symbol Zn .

A newer study suggests implies that an imbalance of zinc is associated with the neuronal damage associated with traumatic brain injury, stroke, and seizures .

Understanding the mechanisms that control brain zinc homeostasis is, therefore, imperative to the development of preventive and treatment regimens for these and other neurological disorders .

In addition to the above, recent review articles have already demonstrated the important role of zinc in the pathophysiology and treatment of affective disorders, plus discussed the potential value of zinc as a marker of these diseases . Most recently, research has shown that polymorphism of the common polymorphism in zinc transporter SLC30A8/ZnT8 may increase susceptibility to type 2 diabetes provided novel insights into the role of zinc in diabetes .

Indication

Zinc can be used for the treatment and prevention of zinc deficiency/its consequences, including stunted growth and acute diarrhea in children, and slowed wound healing. It is also utilized for boosting the immune system, treating the common cold and recurrent ear infections, as well as preventing lower respiratory tract infections .

Associated Conditions
Candidiasis, Common Cold, Diaper Dermatitis, Diaper Rash, Eye redness, Iron Deficiency (ID), Ocular Irritation, Skin Irritation, Sunburn, Wilson's Disease, Zinc Deficiency
Associated Therapies
Dietary and Nutritional Therapies, Dietary supplementation

Zinc Pneumonia Outpatient Trial in Children < 2 Years

Phase 3
Completed
Conditions
Pneumonia
First Posted Date
2005-09-02
Last Posted Date
2022-02-11
Lead Sponsor
International Centre for Diarrhoeal Disease Research, Bangladesh
Target Recruit Count
2260
Registration Number
NCT00142285
Locations
🇧🇩

Kamalapur Urban Site, ICDDR,B: Centre for Health & Population Research, Dhaka, Bangladesh

Safety and Efficacy of Zinc Supplementation in HIV-1-Infected Children in South Africa

Phase 2
Completed
Conditions
HIV Infections
First Posted Date
2005-08-30
Last Posted Date
2005-12-05
Lead Sponsor
Johns Hopkins Bloomberg School of Public Health
Target Recruit Count
100
Registration Number
NCT00138047
Locations
🇿🇦

Grey's Hospital, Pietermaritzburg, South Africa

Zinc and Pneumonia Protocol

Phase 3
Terminated
Conditions
Respiratory Infections, Acute
First Posted Date
2005-08-23
Last Posted Date
2019-01-29
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
600
Registration Number
NCT00133432
Locations
🇹🇿

Muhimbili University, College of Health Sciences, Dar Es Salaam, Tanzania

Long-term Impact and Intervention for Diarrhea in Brazil

Phase 3
Conditions
Diarrheal Disorder
Interventions
First Posted Date
2005-08-23
Last Posted Date
2011-03-08
Lead Sponsor
University of Virginia
Target Recruit Count
321
Registration Number
NCT00133406
Locations
🇧🇷

Federal University of Ceará, Fortaleza, Brazil

Community Trial of Zinc Supplementation on Preschool Child Mortality and Morbidity in Southern Nepal

Phase 3
Completed
Conditions
Nutrition
First Posted Date
2005-04-29
Last Posted Date
2013-05-01
Lead Sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Target Recruit Count
58000
Registration Number
NCT00109551
Locations
🇺🇸

Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States

🇺🇸

Cornell University Division of Nutritional Sciences, Ithaca, New York, United States

🇳🇵

Nepal Nutrition Intervention Project-Sarlahi, Kathmandu and Sarlahi District, Nepal

Zinc Homeostasis and Kinetics in Children With Cystic Fibrosis (CF)

Not Applicable
Completed
Conditions
Cystic Fibrosis
Interventions
First Posted Date
2005-03-02
Last Posted Date
2015-07-30
Lead Sponsor
Cystic Fibrosis Foundation
Target Recruit Count
30
Registration Number
NCT00104494
Locations
🇺🇸

Baylor College of Medicine, Houston, Texas, United States

Randomized Placebo-Controlled Trial (RPCT) of Maize/Zinc in Guatemala

Phase 3
Completed
Conditions
Nutrition
Pregnancy
First Posted Date
2004-12-06
Last Posted Date
2013-12-17
Lead Sponsor
NICHD Global Network for Women's and Children's Health
Target Recruit Count
420
Registration Number
NCT00098202
Locations
🇬🇹

Community, Comalapa, Guatemala

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