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Zinc

Generic Name
Zinc
Brand Names
Vitafol-one, Wilzin
Drug Type
Small Molecule
Chemical Formula
Zn
CAS Number
7440-66-6
Unique Ingredient Identifier
J41CSQ7QDS
Background

A metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with anemia, short stature, hypogonadism, impaired wound healing, and geophagia. It is identified by the symbol Zn .

A newer study suggests implies that an imbalance of zinc is associated with the neuronal damage associated with traumatic brain injury, stroke, and seizures .

Understanding the mechanisms that control brain zinc homeostasis is, therefore, imperative to the development of preventive and treatment regimens for these and other neurological disorders .

In addition to the above, recent review articles have already demonstrated the important role of zinc in the pathophysiology and treatment of affective disorders, plus discussed the potential value of zinc as a marker of these diseases . Most recently, research has shown that polymorphism of the common polymorphism in zinc transporter SLC30A8/ZnT8 may increase susceptibility to type 2 diabetes provided novel insights into the role of zinc in diabetes .

Indication

Zinc can be used for the treatment and prevention of zinc deficiency/its consequences, including stunted growth and acute diarrhea in children, and slowed wound healing. It is also utilized for boosting the immune system, treating the common cold and recurrent ear infections, as well as preventing lower respiratory tract infections .

Associated Conditions
Candidiasis, Common Cold, Diaper Dermatitis, Diaper Rash, Eye redness, Iron Deficiency (ID), Ocular Irritation, Skin Irritation, Sunburn, Wilson's Disease, Zinc Deficiency
Associated Therapies
Dietary and Nutritional Therapies, Dietary supplementation

Role of Zinc in Recurrent Acute Lower Respiratory Infections

Phase 3
Completed
Conditions
Acute Respiratory Infections
Interventions
Other: placebo
First Posted Date
2007-09-27
Last Posted Date
2009-08-06
Lead Sponsor
Jawaharlal Nehru Medical College
Target Recruit Count
208
Registration Number
NCT00536133
Locations
🇮🇳

Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India

Impact of Home Zinc Treatment for Acute Diarrhea in Children

Phase 3
Completed
Conditions
Diarrhea
Interventions
First Posted Date
2007-09-18
Last Posted Date
2010-03-09
Lead Sponsor
Centers for Disease Control and Prevention
Target Recruit Count
3000
Registration Number
NCT00530829
Locations
🇰🇪

Kenya Medical Research Institute, Kisumu, Kenya

Oral Zinc Therapy for the Prevention of Mucositis

Phase 4
Completed
Conditions
Mucositis
Interventions
Drug: Placebo
First Posted Date
2007-03-20
Last Posted Date
2008-10-03
Lead Sponsor
Sheba Medical Center
Target Recruit Count
40
Registration Number
NCT00449592
Locations
🇮🇱

Division of Hematology and Bone Marrow Transplantation, Sheba Medical Center, Ramat-Gan, Israel

A Trial of Zinc and Micronutrients in Tanzanian Children

Phase 3
Completed
Conditions
Diarrheal Illnesses
Respiratory Illness
Growth Faltering
Interventions
Drug: Multivitamins
Drug: Placebo
First Posted Date
2007-01-12
Last Posted Date
2017-03-03
Lead Sponsor
Harvard School of Public Health (HSPH)
Target Recruit Count
2400
Registration Number
NCT00421668
Locations
🇹🇿

Muhimbili Uinverstiy College of Health Sciences, Dar es Salaam, Tanzania

Immunological and Clinical Responses to Zinc in Children With Diarrhoea

Phase 3
Completed
Conditions
Diarrhoea
First Posted Date
2006-12-06
Last Posted Date
2009-02-20
Lead Sponsor
International Centre for Diarrhoeal Disease Research, Bangladesh
Target Recruit Count
338
Registration Number
NCT00408356
Locations
🇧🇩

ICDDR,B. Mirpur Field Site, Dhaka, Bangladesh

Improved Estimation of GFR by Cystatin C in Preventing Contrast Induced Nephropathy by NAC or Zn

Not Applicable
Terminated
Conditions
Chronic Kidney Failure
First Posted Date
2006-11-14
Last Posted Date
2007-02-01
Lead Sponsor
Robert Bosch Gesellschaft für Medizinische Forschung mbH
Target Recruit Count
60
Registration Number
NCT00399256
Locations
🇩🇪

Robert-Bosch-Hospital, Stuttgart, Germany

The CRISIS Prevention Study

Phase 3
Terminated
Conditions
Sepsis
Interventions
Other: saline
Other: sterile water
Dietary Supplement: Glutamine
Other: selenium
Dietary Supplement: whey-protein
First Posted Date
2006-11-02
Last Posted Date
2013-04-18
Lead Sponsor
Michael Dean
Target Recruit Count
293
Registration Number
NCT00395161
Locations
🇺🇸

Childrens Hospital of Los Angeles, Los Angeles, California, United States

🇺🇸

University of California Los Angeles Medical Center, Los Angeles, California, United States

🇺🇸

University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States

and more 4 locations

Efficacy of Zinc in the Treatment of Bronchiolitis and Prevention of Wheezing Respiratory Illness in Children Less Than Two Years Old

Phase 3
Completed
Conditions
Bronchiolitis
First Posted Date
2006-07-21
Last Posted Date
2011-07-12
Lead Sponsor
International Centre for Diarrhoeal Disease Research, Bangladesh
Target Recruit Count
330
Registration Number
NCT00355043
Locations
🇧🇩

ICDDR,B, Dhaka, Bangladesh

Efficacy of Zinc Therapy in Acute Diarrhoea in Young Children

Phase 3
Completed
Conditions
Acute Watery Diarrhoea
First Posted Date
2006-05-12
Last Posted Date
2011-07-12
Lead Sponsor
International Centre for Diarrhoeal Disease Research, Bangladesh
Target Recruit Count
2050
Registration Number
NCT00325247
Locations
🇧🇩

ICDDR,B, Dhaka, Bangladesh

Effectiveness of Adding Zinc to the Current Case Management Package of Diarrhea in a Primary Health Care Setting

Phase 1
Completed
Conditions
Diarrhea
Hospitalization
Interventions
First Posted Date
2006-01-18
Last Posted Date
2008-07-02
Lead Sponsor
Society for Applied Studies
Target Recruit Count
2364
Registration Number
NCT00278681
Locations
🇮🇳

Society for Applied Studies, New Delhi, Delhi, India

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