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Zinc

Generic Name
Zinc
Brand Names
Vitafol-one, Wilzin
Drug Type
Small Molecule
Chemical Formula
Zn
CAS Number
7440-66-6
Unique Ingredient Identifier
J41CSQ7QDS
Background

A metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with anemia, short stature, hypogonadism, impaired wound healing, and geophagia. It is identified by the symbol Zn .

A newer study suggests implies that an imbalance of zinc is associated with the neuronal damage associated with traumatic brain injury, stroke, and seizures .

Understanding the mechanisms that control brain zinc homeostasis is, therefore, imperative to the development of preventive and treatment regimens for these and other neurological disorders .

In addition to the above, recent review articles have already demonstrated the important role of zinc in the pathophysiology and treatment of affective disorders, plus discussed the potential value of zinc as a marker of these diseases . Most recently, research has shown that polymorphism of the common polymorphism in zinc transporter SLC30A8/ZnT8 may increase susceptibility to type 2 diabetes provided novel insights into the role of zinc in diabetes .

Indication

Zinc can be used for the treatment and prevention of zinc deficiency/its consequences, including stunted growth and acute diarrhea in children, and slowed wound healing. It is also utilized for boosting the immune system, treating the common cold and recurrent ear infections, as well as preventing lower respiratory tract infections .

Associated Conditions
Candidiasis, Common Cold, Diaper Dermatitis, Diaper Rash, Eye redness, Iron Deficiency (ID), Ocular Irritation, Skin Irritation, Sunburn, Wilson's Disease, Zinc Deficiency
Associated Therapies
Dietary and Nutritional Therapies, Dietary supplementation

Addition of Zinc to the Current Case Management Package of Diarrhea in a Primary Health Care Setting

Not Applicable
Completed
Conditions
Diarrhea
Hospitalization
Mortality
Interventions
First Posted Date
2006-01-18
Last Posted Date
2015-06-16
Lead Sponsor
Society for Applied Studies
Target Recruit Count
20032
Registration Number
NCT00278746
Locations
๐Ÿ‡ฎ๐Ÿ‡ณ

Society for Applied Studies, New Delhi, Delhi, India

Effect of Zinc and Vitamin A Supplementation on Diarrhea, Physical Growth and Immune Response in Malnourished Children

Not Applicable
Completed
Conditions
Diarrhea
Pneumonia
Acute Respiratory Tract Infection
Interventions
Drug: Placebo and vitamin A single dose at enrollment
First Posted Date
2006-01-04
Last Posted Date
2012-04-03
Lead Sponsor
Society for Applied Studies
Target Recruit Count
2482
Registration Number
NCT00272116
Locations
๐Ÿ‡ฎ๐Ÿ‡ณ

All India Institute of Medical Sciences, New Delhi, Delhi, India

Impact of Zinc Supplementation in Low Birth Weight Infants on Severe Morbidity, Mortality and Zinc Status: A Randomized Controlled Trial

Not Applicable
Completed
Conditions
Diarrhea
Respiratory Infection
Low Birth Weight
First Posted Date
2006-01-04
Last Posted Date
2009-09-03
Lead Sponsor
Society for Applied Studies
Target Recruit Count
2000
Registration Number
NCT00272142
Locations
๐Ÿ‡ฎ๐Ÿ‡ณ

Society for Applied Studies, New Delhi, Delhi, India

Impact of Zinc Supplementation on Mortality and Hospitalizations in Children Aged 1 Months to 23 Months

Not Applicable
Completed
Conditions
Morbidity
Mortality
Diarrhea
Pneumonia
Interventions
First Posted Date
2005-12-23
Last Posted Date
2008-07-01
Lead Sponsor
Society for Applied Studies
Target Recruit Count
94359
Registration Number
NCT00269542

Therapeutic Zinc in Childhood Pneumonia

Phase 2
Completed
Conditions
Pneumonia
Interventions
First Posted Date
2005-11-11
Last Posted Date
2009-10-06
Lead Sponsor
Centre For International Health
Target Recruit Count
641
Registration Number
NCT00252304
Locations
๐Ÿ‡ณ๐Ÿ‡ต

Kanti Children Hospital, Kathmandu, Nepal

Vitamin A and Zinc: Prevention of Pneumonia (VAZPOP) Study

Phase 4
Completed
Conditions
Pneumonia
Diarrhea
Acute Upper Respiratory Tract Infections
First Posted Date
2005-09-28
Last Posted Date
2005-09-28
Lead Sponsor
Tufts University
Target Recruit Count
2582
Registration Number
NCT00228254
Locations
๐Ÿ‡บ๐Ÿ‡ธ

Tufts University School of Medicine, Boston, Massachusetts, United States

๐Ÿ‡ช๐Ÿ‡จ

Corporacion Ecuatoriana de Biotecnologia, Quito, Pinchincha, Ecuador

Zinc Supplementation in Cholera Patients

Phase 3
Completed
Conditions
Cholera
First Posted Date
2005-09-27
Last Posted Date
2005-10-20
Lead Sponsor
International Centre for Diarrhoeal Disease Research, Bangladesh
Registration Number
NCT00226616
Locations
๐Ÿ‡ง๐Ÿ‡ฉ

ICDDR,B, Dhaka hospital, Dhaka, Bangladesh

๐Ÿ‡ง๐Ÿ‡ฉ

S.k.Roy, Dhaka, Bangladesh

A Phase 2 Clinical Trial of the Safety and Effects of IRX-2 in Treating Patients With Operable Head and Neck Cancer

Phase 2
Completed
Conditions
Squamous Cell Carcinoma of the Head and Neck
Interventions
First Posted Date
2005-09-21
Last Posted Date
2020-12-11
Lead Sponsor
Brooklyn ImmunoTherapeutics, LLC
Target Recruit Count
27
Registration Number
NCT00210470

Efficacy of Zinc in the Treatment of Pneumonia

Not Applicable
Completed
Conditions
Pneumonia
Interventions
First Posted Date
2005-09-20
Last Posted Date
2015-01-12
Lead Sponsor
Johns Hopkins Bloomberg School of Public Health
Target Recruit Count
299
Registration Number
NCT00198666

CHIZAP: Community- and Health Facility-Based Intervention With Zinc as Adjuvant Therapy for Childhood Pneumonia

Phase 2
Completed
Conditions
Pneumonia
Interventions
First Posted Date
2005-09-08
Last Posted Date
2022-03-16
Lead Sponsor
Centre For International Health
Target Recruit Count
2628
Registration Number
NCT00148733
Locations
๐Ÿ‡ณ๐Ÿ‡ต

Siddhi Memorial Hospital (SMH),Bhelukhel, Bhimsensthan, Bhaktapur, Nepal

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