Losartan
- Generic Name
- Losartan
- Brand Names
- Hyzaar, Cozaar
- Drug Type
- Small Molecule
- Chemical Formula
- C22H23ClN6O
- CAS Number
- 114798-26-4
- Unique Ingredient Identifier
- JMS50MPO89
- Background
Losartan is an angiotensin II receptor blocker (ARB) used to treat hypertension. Angiotensin-converting enzyme (ACE) inhibitors are used for a similar indication but are associated with a cough. When patients with ACE inhibitor associated coughs are switched to ARBs like losartan, they have an incidence of cough similar to placebo or hydrochlorothiazide. Los...
- Indication
Losartan is indicated to treat hypertension in patients older than 6 years, reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy (though this benefit may not extend to patients with African heritage), and to treat diabetic nephropathy with elevated serum creatinine and proteinuria in patients with type 2 diabetes and hyper...
- Associated Conditions
- Diabetic Nephropathy, Ventricular Dysfunction, Hypertension, Marfan Syndrome, Ischemic Stroke
- Associated Therapies
- -
Ocsaar and CYP2C9 Ploymorphism, Is There a Connection Between Pharmacokinetics, Pharmacodynamics and Pharmacogenetics?
- First Posted Date
- 2008-08-12
- Last Posted Date
- 2008-08-12
- Lead Sponsor
- Assaf-Harofeh Medical Center
- Target Recruit Count
- 30
- Registration Number
- NCT00732966
Effects of Losartan Versus Atenolol on Aortic and Cardiac Muscle Stiffness in Adults With Marfan Syndrome
- First Posted Date
- 2008-07-29
- Last Posted Date
- 2014-09-09
- Lead Sponsor
- Brigham and Women's Hospital
- Target Recruit Count
- 40
- Registration Number
- NCT00723801
- Locations
- 🇺🇸
Brigham and Women's Hospital, Boston, Massachusetts, United States
Study to Evaluate the Effect of Simvastatin, Losartan and Pioglitazone on Patients With Peripheral Arterial Disease.
- Conditions
- Interventions
- First Posted Date
- 2008-07-23
- Last Posted Date
- 2021-05-14
- Lead Sponsor
- Medtronic Endovascular
- Target Recruit Count
- 164
- Registration Number
- NCT00720577
Efficacy of Losartan in Preventing Progression of COPD
- Conditions
- Interventions
- First Posted Date
- 2008-07-22
- Last Posted Date
- 2017-04-25
- Lead Sponsor
- Johns Hopkins University
- Target Recruit Count
- 106
- Registration Number
- NCT00720226
- Locations
- 🇺🇸
Johns Hopkins Asthma and Allergy Center, Baltimore, Maryland, United States
Losartan in Hypertensive Men and Women With Sleep Apnea Before and on Continuous Positive Airway Pressure (CPAP) Treatment
- First Posted Date
- 2008-06-19
- Last Posted Date
- 2020-10-22
- Lead Sponsor
- Skaraborg Hospital
- Target Recruit Count
- 90
- Registration Number
- NCT00701428
- Locations
- 🇸🇪
University of Gothenburg, Sahlgrenska Academy, Gothenburg, West Gotaland, Sweden
Rosiglitazone Versus Rosiglitazone and Metformin Versus Rosiglitazone and Avandia in the Treatment of Nonalcoholic Steatohepatitis (NASH)
- Conditions
- Interventions
- First Posted Date
- 2008-06-17
- Last Posted Date
- 2009-06-19
- Lead Sponsor
- Brooke Army Medical Center
- Target Recruit Count
- 165
- Registration Number
- NCT00699036
- Locations
- 🇺🇸
Brooke Army Medical Center, San Antonio, Texas, United States
Nebivolol Versus Losartan Versus Nebivolol+Losartan Against Aortic Root Dilation in Genotyped Marfan Patients
- Conditions
- Interventions
- First Posted Date
- 2008-05-23
- Last Posted Date
- 2011-07-22
- Lead Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
- Target Recruit Count
- 291
- Registration Number
- NCT00683124
- Locations
- 🇮🇹
IRCCS Foundation San Matteo Hospital, Pavia, Italy
A Randomized Clinical Trial To Study Losartan On Endothelial Dysfunction and Insulin Resistance In Obese Patients
- Conditions
- Interventions
- First Posted Date
- 2008-05-12
- Last Posted Date
- 2018-09-06
- Lead Sponsor
- Brigham and Women's Hospital
- Target Recruit Count
- 53
- Registration Number
- NCT00675987
- Locations
- 🇺🇸
CAVS Clinical Research Center, Little Rock, Arkansas, United States
🇺🇸St. Lukes Roosevelt Hospital, New York, New York, United States
🇺🇸University of Miami Diabetes Research Institute, Miami, Florida, United States
Effects of Losartan on Insulin Resistance in Patients With Heart Failure
- Conditions
- First Posted Date
- 2008-04-22
- Last Posted Date
- 2008-04-22
- Lead Sponsor
- Tottori University Hospital
- Target Recruit Count
- 16
- Registration Number
- NCT00663377
Effects Of Losartan On Myocardial Structure In Diabetic Hypertensive Patients With Left Ventricular
- First Posted Date
- 2008-04-16
- Last Posted Date
- 2008-04-16
- Lead Sponsor
- University of Pavia
- Target Recruit Count
- 100
- Registration Number
- NCT00659451
- Locations
- 🇮🇹
University of Pavia, Pavia, Italy
Drug Development Updates
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